FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013182015> ?p ?o ?g. }

• W2013182015 endingPage "713" @default.
• W2013182015 startingPage "705" @default.
• W2013182015 abstract "The RNA interference pathway functions as an antiviral defense in invertebrates. In order to generate a phenotypic marker which “senses” the status of the RNAi pathway in Aedes aegypti, transgenic strains were developed to express EGFP and DsRED marker genes in the eye, as well as double-stranded RNA homologous to a portion of the EGFP gene. Transgenic “sensor” mosquitoes exhibited robust eye-specific DsRED expression with little EGFP, indicating RNAi-based silencing. Cloning and high-throughput sequencing of small RNAs confirmed that the inverted-repeat transgene was successfully processed into short-interfering RNAs by the mosquito RNAi pathway. When the A. aegypti homologues of the genes DCR-2 or AGO-2 were knocked down, a clear increase in EGFP fluorescence was observed in the mosquito eyes. Knockdown of DCR-2 was also associated with an increase in EGFP mRNA levels, as determined by Northern blot and real-time PCR. Knockdown of AGO-3, a gene involved in the germline-specific piRNA pathway, did not restore EGFP expression at either the mRNA or protein level. This transgenic sensor strain can now be used to identify other components of the mosquito RNAi pathway and has the potential to be used in the identification of arboviral suppressors of RNAi." @default.
• W2013182015 created "2016-06-24" @default.
• W2013182015 creator A5015549381 @default.
• W2013182015 creator A5025138373 @default.
• W2013182015 creator A5028277553 @default.
• W2013182015 creator A5088503493 @default.
• W2013182015 date "2008-07-01" @default.
• W2013182015 modified "2023-09-23" @default.
• W2013182015 title "A transgenic sensor strain for monitoring the RNAi pathway in the yellow fever mosquito, Aedes aegypti" @default.
• W2013182015 cites W1602781299 @default.
• W2013182015 cites W1971549481 @default.
• W2013182015 cites W1971550264 @default.
• W2013182015 cites W1976342457 @default.
• W2013182015 cites W1977743697 @default.
• W2013182015 cites W1986875579 @default.
• W2013182015 cites W1989759946 @default.
• W2013182015 cites W2003330861 @default.
• W2013182015 cites W2018802169 @default.
• W2013182015 cites W2025172328 @default.
• W2013182015 cites W2029433700 @default.
• W2013182015 cites W2031047143 @default.
• W2013182015 cites W2032382765 @default.
• W2013182015 cites W2039245874 @default.
• W2013182015 cites W2042176182 @default.
• W2013182015 cites W2042587404 @default.
• W2013182015 cites W2047538913 @default.
• W2013182015 cites W2051281606 @default.
• W2013182015 cites W2053350421 @default.
• W2013182015 cites W2054156026 @default.
• W2013182015 cites W2060989535 @default.
• W2013182015 cites W2063728571 @default.
• W2013182015 cites W2065687142 @default.
• W2013182015 cites W2082867367 @default.
• W2013182015 cites W2100729864 @default.
• W2013182015 cites W2101543035 @default.
• W2013182015 cites W2104695439 @default.
• W2013182015 cites W2116603538 @default.
• W2013182015 cites W2117991391 @default.
• W2013182015 cites W2128882718 @default.
• W2013182015 cites W2138708625 @default.
• W2013182015 cites W2139200003 @default.
• W2013182015 cites W2139268538 @default.
• W2013182015 cites W2141987735 @default.
• W2013182015 cites W2147499400 @default.
• W2013182015 cites W2149788324 @default.
• W2013182015 cites W2158159015 @default.
• W2013182015 cites W2161208250 @default.
• W2013182015 cites W2166293484 @default.
• W2013182015 cites W2169189437 @default.
• W2013182015 cites W2171158206 @default.
• W2013182015 cites W2468169264 @default.
• W2013182015 cites W2770975681 @default.
• W2013182015 cites W4211248568 @default.
• W2013182015 doi "https://doi.org/10.1016/j.ibmb.2008.04.002" @default.
• W2013182015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2518454" @default.
• W2013182015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18549956" @default.
• W2013182015 hasPublicationYear "2008" @default.
• W2013182015 type Work @default.
• W2013182015 sameAs 2013182015 @default.
• W2013182015 citedByCount "39" @default.
• W2013182015 countsByYear W20131820152012 @default.
• W2013182015 countsByYear W20131820152013 @default.
• W2013182015 countsByYear W20131820152014 @default.
• W2013182015 countsByYear W20131820152015 @default.
• W2013182015 countsByYear W20131820152016 @default.
• W2013182015 countsByYear W20131820152017 @default.
• W2013182015 countsByYear W20131820152018 @default.
• W2013182015 countsByYear W20131820152021 @default.
• W2013182015 countsByYear W20131820152022 @default.
• W2013182015 countsByYear W20131820152023 @default.
• W2013182015 crossrefType "journal-article" @default.
• W2013182015 hasAuthorship W2013182015A5015549381 @default.
• W2013182015 hasAuthorship W2013182015A5025138373 @default.
• W2013182015 hasAuthorship W2013182015A5028277553 @default.
• W2013182015 hasAuthorship W2013182015A5088503493 @default.
• W2013182015 hasBestOaLocation W20131820152 @default.
• W2013182015 hasConcept C102230213 @default.
• W2013182015 hasConcept C104317684 @default.
• W2013182015 hasConcept C119056186 @default.
• W2013182015 hasConcept C142613039 @default.
• W2013182015 hasConcept C153911025 @default.
• W2013182015 hasConcept C166703698 @default.
• W2013182015 hasConcept C173396325 @default.
• W2013182015 hasConcept C173758957 @default.
• W2013182015 hasConcept C2191507 @default.
• W2013182015 hasConcept C2777775583 @default.
• W2013182015 hasConcept C54355233 @default.
• W2013182015 hasConcept C59822182 @default.
• W2013182015 hasConcept C67705224 @default.
• W2013182015 hasConcept C86803240 @default.
• W2013182015 hasConcept C95444343 @default.
• W2013182015 hasConceptScore W2013182015C102230213 @default.
• W2013182015 hasConceptScore W2013182015C104317684 @default.
• W2013182015 hasConceptScore W2013182015C119056186 @default.
• W2013182015 hasConceptScore W2013182015C142613039 @default.
• W2013182015 hasConceptScore W2013182015C153911025 @default.
• W2013182015 hasConceptScore W2013182015C166703698 @default.
• W2013182015 hasConceptScore W2013182015C173396325 @default.

• next