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- W2013183227 abstract "Intracerebral hemorrhage (ICH), which constitutes 10 to 15% of all strokes and affects approximately 65,000 people each year in the United States, has the highest mortality rate of all stroke subtypes. Hypertension, cerebral amyloid angiopathy, and anticoagulation underlie the majority of cases of ICH. Warfarin not only increases the risk but also increases the severity of ICH by causing hematoma expansion. With the advent of gradient-echo magnetic resonance imaging, patients with underlying cerebral amyloid angiopathy or hypertensive vasculopathy can be identified, and measures can be taken to prevent ICH. Initiating an antihypertensive regimen in a patient with nonlobar microbleeds suggestive of hypertensive vasculopathy, and withholding warfarin in patients with lobar microbleeds suggestive of cerebral amyloid angiopathy, are emerging prevention strategies. Although a treatment for cerebral amyloid angiopathy does not exist, agents targeting beta-amyloid metabolism and bioactivity are promising candidates. Strategies for preventing warfarin-associated hemorrhage include strict monitoring of anticoagulation levels and using agents such as direct thrombin inhibitors. The future of ICH management lies in therapies targeted at the pathophysiological steps in ICH. Potential treatments include glutamate receptor antagonists for preventing glutamate excitotoxicity, matrix metalloproteinase and thrombin inhibitors for preventing perihematomal edema, and recombinant activated factor VII for preventing hematomal expansion." @default.
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- W2013183227 date "2005-01-01" @default.
- W2013183227 modified "2023-10-16" @default.
- W2013183227 title "Treatment and Prevention of Primary Intracerebral Hemorrhage" @default.
- W2013183227 cites W1522694313 @default.
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- W2013183227 cites W1594119953 @default.
- W2013183227 cites W1674692411 @default.
- W2013183227 cites W1738640266 @default.
- W2013183227 cites W1858255399 @default.
- W2013183227 cites W1964428139 @default.
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- W2013183227 cites W1978171275 @default.
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- W2013183227 cites W1985952027 @default.
- W2013183227 cites W1992953826 @default.
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- W2013183227 cites W1998801224 @default.
- W2013183227 cites W2001688761 @default.
- W2013183227 cites W2011074307 @default.
- W2013183227 cites W2012273895 @default.
- W2013183227 cites W2013520583 @default.
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- W2013183227 cites W2024147409 @default.
- W2013183227 cites W2025313184 @default.
- W2013183227 cites W2031990245 @default.
- W2013183227 cites W2035028304 @default.
- W2013183227 cites W2035239697 @default.
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- W2013183227 doi "https://doi.org/10.1055/s-2005-923538" @default.
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