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• W2013191030 endingPage "1298" @default.
• W2013191030 startingPage "1290" @default.
• W2013191030 abstract "ADP-ribosyl cyclase (ADPR-cyclase) produces a Ca2+-mobilizing second messenger cyclic ADP-ribose (cADPR) from β-NAD+. In this study, we examined the molecular basis of which β-adrenergic receptor (βAR) stimulation induces cADPR formation and characterized cardiac ADPR-cyclase. The results revealed that isoproterenol-mediated increase of [Ca2+]i in rat cardiomyocytes was blocked by pretreatment with a cADPR antagonistic derivative 8-Br-cADPR, a PKA inhibitor H89 or high concentration of ryanodine. Moreover, incubation of ventricular lysates with isoproterenol, forskolin or cAMP resulted in activation of ADPR-cyclase that was inhibited by pretreatment with H89. Supporting the observations, the cADPR antagonist and H89 blocked 8-CPT-cAMP, a cell-permeant cAMP analog-induced increase in [Ca2+]i but not cGMP-mediated increase. Characterization of partially purified cardiac ADPR-cyclase showed a molecular mass of approximately 42 kDa and no cross-activity with CD38 antibodies, and the enzyme activity was inhibited by Zn2+ but not dithiothreitol. Microinjection of the enzyme into rat cardiomyocytes increased the level of [Ca2+]i in a concentration-dependent manner. The enzyme-mediated increase of [Ca2+]i was blocked by the cADPR antagonist. These findings suggest that βAR-mediated regulation of [Ca2+]i in rat cardiomyocytes is primed by activation of cardiac ADPR-cyclase via cAMP/PKA signaling and that cardiac ADPR-cyclase differs from CD38 in biochemical and immunological properties." @default.
• W2013191030 created "2016-06-24" @default.
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• W2013191030 date "2005-05-01" @default.
• W2013191030 modified "2023-10-18" @default.
• W2013191030 title "ADP-ribosyl cyclase couples to cyclic AMP signaling in the cardiomyocytes" @default.
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• W2013191030 doi "https://doi.org/10.1016/j.bbrc.2005.03.114" @default.
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