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• W2013194090 abstract "One of our major research interests is to define BCL-2 family function in the cellular decision to induce mitochondrial outer membrane permeabilization and apoptosis. Curiosity in BCL-2 family - mitochondrial interactions led to the identification that the sphingolipid pathway plays a crucial role in BCL-2 family function. For approximately 20 years, sphingolipid biology and apoptotic mechanisms have criss-crossed, but remained distinct, as neither literature could explain the observable interplay between these pathways. We recently identified that two products within the sphingolipid pathway, sphingosine-1-PO4 and hexadecenal, directly regulate BAK and BAX activation, respectively. Furthermore, our work suggests that mitochondrial communication with heterotypic membrane and/or organelles may be an important regulatory mechanism for apoptotic sensitivity." @default.
• W2013194090 created "2016-06-24" @default.
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• W2013194090 date "2013-03-01" @default.
• W2013194090 modified "2023-10-01" @default.
• W2013194090 title "Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis" @default.
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• W2013194090 doi "https://doi.org/10.4161/cib.22872" @default.
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