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- W2013197250 abstract "Abstract pH in animal cell cultures decreases due to production of metabolites like lactate. pH control via measurement and base addition is not easily possible in small‐scale culture formats like tissue‐culture flasks and shake flasks. A hydrogel‐based system is reported for in situ pH maintenance without pH measurement in such formats, and is demonstrated to maintain pH between 6.8 and 7.2 for a suspension CHO cell line in CD CHO medium and between 7.3 and 7.5 for adherent A549 cells in DMEM:F12 containing 10% FBS. This system for pH maintenance, along with our previous report of hydrogels for controlled nutrient delivery in shake flasks can allow shake flasks to better mimic bioreactor‐based fed batch operation for initial screening during cell line and process development for recombinant protein production in mammalian cells. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 2012" @default.
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- W2013197250 date "2012-09-21" @default.
- W2013197250 modified "2023-10-18" @default.
- W2013197250 title "In situ pH maintenance for mammalian cell cultures in shake flasks and tissue culture flasks" @default.
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- W2013197250 doi "https://doi.org/10.1002/btpr.1614" @default.
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