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- W2013198324 abstract "Because of the lack of other effective control measures, and its reported success in the prevention of recurrent rheumatic fever in civilian groups, investigations into the use of oral penicillin for the prophylaxis of epidemic streptococcal infections among naval personnel were begun in 1951.1 The initial study demonstrated that a 100,000-unit tablet of oral penicillin once daily was highly effective in preventing men from developing streptococcal infections under conditions of considerable risk. The purpose of this paper is to summarize additional investigations made in Navy recruit populations and to report some previously unreported data. With one exception,2 all studies in the Navy have been carried out by the Naval Medical Research Unit No.4. Commercial buffered tablets of penicillin G have been employed in studies having two general objectives: one, to learn the smallest dose that would effectively suppress epidemics; and two, to learn the smallest dose practicable for use in prophylaxis that would eliminate group A streptococci from a maximum number of carriers. It was foreseen that under some circumstances continuous prophylaxis over a considerable period of time might be necessary. For economic reasons, since the involved populations could number in the hundreds of thousands during full mobilization, the minimum effective dose was sought. It was also thought that it might be possible, under some conditions, to cause a more or less prolonged interruption of an epidemic by a short course of penicillin which would eliminate streptococci from most carriers." @default.
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- W2013198324 date "1955-05-01" @default.
- W2013198324 modified "2023-09-27" @default.
- W2013198324 title "Oral Penicillin Prophylaxis of Streptococcal Infections" @default.
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- W2013198324 doi "https://doi.org/10.2105/ajph.45.5_pt_1.662" @default.
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