Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013201036> ?p ?o ?g. }
- W2013201036 endingPage "1233" @default.
- W2013201036 startingPage "1227" @default.
- W2013201036 abstract "Serotonin (5-HT) has been long recognized to modulate the stress response, and dysfunction of 5-HT has been implicated in numerous stress disorders. Accordingly, the 5-HT system has been targeted for the treatment of stress disorders. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in 5-HT synthesis, and the recent identification of a second, neuron-specific TPH isoform (TPH2) opened up a new area of research. With a decade of extensive investigation, it is now recognized that: (1) TPH2 exhibits a highly flexible gene expression that is modulated by an increasing number of internal and external environmental factors including the biological clock, stressors, endogenous hormones, and antidepressant therapies; and (2) genetically determined TPH2 activity is linked to a growing body of stress-related neuronal correlates and behavioral traits. These findings reveal an active role of TPH2 in the stress response and provide new insights into the long recognized but not yet fully understood 5-HT–stress interaction. As a major modulator of 5-HT neurotransmission and the stress response, TPH2 is of both pathophysiological and pharmacological significance, and is emerging as a new therapeutic target for the treatment of stress disorders. Given that numerous antidepressant therapies influence TPH2 gene expression, TPH2 is already inadvertently targeted for the treatment of stress disorders. With increased understanding of the regulation of TPH2 activity we can now purposely utilize TPH2 as a target to develop new or optimize current therapies, which are expected to greatly improve the prevention and treatment of a wide variety of stress disorders." @default.
- W2013201036 created "2016-06-24" @default.
- W2013201036 creator A5054206531 @default.
- W2013201036 creator A5059830687 @default.
- W2013201036 date "2013-05-01" @default.
- W2013201036 modified "2023-10-02" @default.
- W2013201036 title "Tryptophan hydroxylase-2: An emerging therapeutic target for stress disorders" @default.
- W2013201036 cites W1499534488 @default.
- W2013201036 cites W1524125780 @default.
- W2013201036 cites W1886309510 @default.
- W2013201036 cites W1966733693 @default.
- W2013201036 cites W1970912336 @default.
- W2013201036 cites W1976114760 @default.
- W2013201036 cites W1978633821 @default.
- W2013201036 cites W1979546416 @default.
- W2013201036 cites W1986987168 @default.
- W2013201036 cites W1987469263 @default.
- W2013201036 cites W1988107743 @default.
- W2013201036 cites W1991000711 @default.
- W2013201036 cites W1991436104 @default.
- W2013201036 cites W1992981136 @default.
- W2013201036 cites W1993159686 @default.
- W2013201036 cites W1993278041 @default.
- W2013201036 cites W1994666127 @default.
- W2013201036 cites W1995662201 @default.
- W2013201036 cites W1997254455 @default.
- W2013201036 cites W1998138869 @default.
- W2013201036 cites W1998143129 @default.
- W2013201036 cites W1998662981 @default.
- W2013201036 cites W1999029897 @default.
- W2013201036 cites W1999166381 @default.
- W2013201036 cites W2001371079 @default.
- W2013201036 cites W2006716163 @default.
- W2013201036 cites W2007249713 @default.
- W2013201036 cites W2008318394 @default.
- W2013201036 cites W2009884389 @default.
- W2013201036 cites W2011314915 @default.
- W2013201036 cites W2012597831 @default.
- W2013201036 cites W2014882506 @default.
- W2013201036 cites W2020200956 @default.
- W2013201036 cites W2020944445 @default.
- W2013201036 cites W2026529233 @default.
- W2013201036 cites W2029165147 @default.
- W2013201036 cites W2035663126 @default.
- W2013201036 cites W2036691617 @default.
- W2013201036 cites W2037293560 @default.
- W2013201036 cites W2038059327 @default.
- W2013201036 cites W2042397231 @default.
- W2013201036 cites W2043741320 @default.
- W2013201036 cites W2051346922 @default.
- W2013201036 cites W2052230940 @default.
- W2013201036 cites W2055616552 @default.
- W2013201036 cites W2056615896 @default.
- W2013201036 cites W2058498398 @default.
- W2013201036 cites W2058702631 @default.
- W2013201036 cites W2060975407 @default.
- W2013201036 cites W2061951616 @default.
- W2013201036 cites W2063959960 @default.
- W2013201036 cites W2066311168 @default.
- W2013201036 cites W2067632849 @default.
- W2013201036 cites W2070272723 @default.
- W2013201036 cites W2073814401 @default.
- W2013201036 cites W2074877352 @default.
- W2013201036 cites W2076507733 @default.
- W2013201036 cites W2079005914 @default.
- W2013201036 cites W2085881951 @default.
- W2013201036 cites W2088243227 @default.
- W2013201036 cites W2088419324 @default.
- W2013201036 cites W2088954501 @default.
- W2013201036 cites W2090641374 @default.
- W2013201036 cites W2092446347 @default.
- W2013201036 cites W2092647381 @default.
- W2013201036 cites W2094015561 @default.
- W2013201036 cites W2096221719 @default.
- W2013201036 cites W2098031897 @default.
- W2013201036 cites W2103748523 @default.
- W2013201036 cites W2104536121 @default.
- W2013201036 cites W2106183995 @default.
- W2013201036 cites W2109416272 @default.
- W2013201036 cites W2110726089 @default.
- W2013201036 cites W2112886301 @default.
- W2013201036 cites W2117286783 @default.
- W2013201036 cites W2123649103 @default.
- W2013201036 cites W2129865592 @default.
- W2013201036 cites W2130291560 @default.
- W2013201036 cites W2145981956 @default.
- W2013201036 cites W2146357502 @default.
- W2013201036 cites W2151558424 @default.
- W2013201036 cites W2157217869 @default.
- W2013201036 cites W2159909358 @default.
- W2013201036 cites W2164512416 @default.
- W2013201036 cites W2171621001 @default.
- W2013201036 doi "https://doi.org/10.1016/j.bcp.2013.02.018" @default.
- W2013201036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3727219" @default.
- W2013201036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23435356" @default.
- W2013201036 hasPublicationYear "2013" @default.
- W2013201036 type Work @default.
- W2013201036 sameAs 2013201036 @default.