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- W2013201317 abstract "Most of the accumulated evidence (1) supports the view that low X-ray doses, which cause reversible mitotic delay, have their effect during the period of the cell cycle termed G2--that is, between DNA synthesis (S) and mitosis. This view was put forward some years ago by Kelly (2). However, since then evidence has been presented indicating that irradiation delays DNA synthesis and therefore mitosis (3, 4). There is little doubt that high X-ray doses do affect DNA synthesis (5-9), but the evidence implicating DNA synthesis in delay after low doses is less strong. In this paper we shall present experimental results that are particularly conclusive in demonstrating the lability of G2, and not S, to low doses of X-irradiation. Previous experimenters have often utilized asynchronous cell populations as research material. More precise information about the effect of X-rays on different cellular processes and the relationship of these processes to reversible mitotic delay could be obtained by using a well-synchronized cell population. Such a population is easily obtained with simultaneously fertilized sea urchin eggs. Here the first few divisions after fertilization have a normal distribution (for any point in the cell cycle) usually characterized by a standard deviation of only 3 or 4 minutes. Besides being easily synchronized, the sea urchin egg has the advantage of having a DNA-synthetic period after fertilization that is not preceded by mitosis. This first DNA synthesis occurs about 30 minutes after fertilization, at the time of pronuclear fusion. The second synthetic period begins in telophase of the first mitosis (10). Therefore in one cell we should be able to test whether X-rays affect DNA synthesis or some other aspect of the cell cycle. If the first synthesis is delayed, then we may" @default.
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- W2013201317 date "1965-12-01" @default.
- W2013201317 modified "2023-09-24" @default.
- W2013201317 title "Analysis of DNA Synthesis and X-Ray-Induced Mitotic Delay in Sea Urchin Eggs" @default.
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- W2013201317 doi "https://doi.org/10.2307/3571864" @default.
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