Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013208056> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2013208056 endingPage "1856" @default.
- W2013208056 startingPage "1847" @default.
- W2013208056 abstract "6-Ethyl-9-oxaergoline (EOE) and its enantiomers were compared with apomorphine in a number of tests designed to measure dopamine (DA) agonist activity within the central nervous system. In rats, the tests were: interaction with DA receptors labeled with 3H-apomorphine or 3H-spiroperidol; the effects on DA synthesis as assessed by the gamma-butyrolactone procedure; turning in 6-OHDA lesioned animals; stereotypy; and, slowing of DA cell firing rates. In the mouse, locomotor activity, hypothermia and postural asymmetry in caudectomized animals were studied. Emesis in the beagle was also examined. The (-)-enantiomer of EOE was more potent than either the (+)-enantiomer or the racemate in all tests. With the exception of inducing stereotypy and the displacement of 3H-apomorphine from rat striatal membranes, (-)-EOE was equi- or more potent than apomorphine in all test procedures. (-)-EOE was effective following oral administration and exhibited a longer duration of action than apomorphine. The results indicate EOE is a potent DA agonist." @default.
- W2013208056 created "2016-06-24" @default.
- W2013208056 creator A5023335669 @default.
- W2013208056 creator A5038977774 @default.
- W2013208056 creator A5041013124 @default.
- W2013208056 creator A5050640732 @default.
- W2013208056 creator A5065152049 @default.
- W2013208056 creator A5089143256 @default.
- W2013208056 date "1982-05-01" @default.
- W2013208056 modified "2023-09-23" @default.
- W2013208056 title "Potent dopamine agonist activity of a novel ergoline, 6-Ethyl-9-oxaergoline (EOE)" @default.
- W2013208056 cites W1978442412 @default.
- W2013208056 cites W1980449778 @default.
- W2013208056 cites W1990680291 @default.
- W2013208056 cites W2002414581 @default.
- W2013208056 cites W2004969795 @default.
- W2013208056 cites W2005313512 @default.
- W2013208056 cites W2009391318 @default.
- W2013208056 cites W2021513016 @default.
- W2013208056 cites W2035188344 @default.
- W2013208056 cites W2044491952 @default.
- W2013208056 cites W2059878691 @default.
- W2013208056 cites W2066113689 @default.
- W2013208056 cites W2067363410 @default.
- W2013208056 cites W2068866069 @default.
- W2013208056 cites W2082786261 @default.
- W2013208056 cites W2092145492 @default.
- W2013208056 cites W2095296181 @default.
- W2013208056 cites W2167697864 @default.
- W2013208056 cites W2312905901 @default.
- W2013208056 cites W3023211482 @default.
- W2013208056 doi "https://doi.org/10.1016/0024-3205(82)90323-x" @default.
- W2013208056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7201555" @default.
- W2013208056 hasPublicationYear "1982" @default.
- W2013208056 type Work @default.
- W2013208056 sameAs 2013208056 @default.
- W2013208056 citedByCount "14" @default.
- W2013208056 crossrefType "journal-article" @default.
- W2013208056 hasAuthorship W2013208056A5023335669 @default.
- W2013208056 hasAuthorship W2013208056A5038977774 @default.
- W2013208056 hasAuthorship W2013208056A5041013124 @default.
- W2013208056 hasAuthorship W2013208056A5050640732 @default.
- W2013208056 hasAuthorship W2013208056A5065152049 @default.
- W2013208056 hasAuthorship W2013208056A5089143256 @default.
- W2013208056 hasConcept C120069818 @default.
- W2013208056 hasConcept C126322002 @default.
- W2013208056 hasConcept C134018914 @default.
- W2013208056 hasConcept C170493617 @default.
- W2013208056 hasConcept C185592680 @default.
- W2013208056 hasConcept C2777193897 @default.
- W2013208056 hasConcept C2777525119 @default.
- W2013208056 hasConcept C2778258207 @default.
- W2013208056 hasConcept C2778296116 @default.
- W2013208056 hasConcept C2778938600 @default.
- W2013208056 hasConcept C2779459141 @default.
- W2013208056 hasConcept C486523 @default.
- W2013208056 hasConcept C513476851 @default.
- W2013208056 hasConcept C55493867 @default.
- W2013208056 hasConcept C71240020 @default.
- W2013208056 hasConcept C71924100 @default.
- W2013208056 hasConcept C98274493 @default.
- W2013208056 hasConceptScore W2013208056C120069818 @default.
- W2013208056 hasConceptScore W2013208056C126322002 @default.
- W2013208056 hasConceptScore W2013208056C134018914 @default.
- W2013208056 hasConceptScore W2013208056C170493617 @default.
- W2013208056 hasConceptScore W2013208056C185592680 @default.
- W2013208056 hasConceptScore W2013208056C2777193897 @default.
- W2013208056 hasConceptScore W2013208056C2777525119 @default.
- W2013208056 hasConceptScore W2013208056C2778258207 @default.
- W2013208056 hasConceptScore W2013208056C2778296116 @default.
- W2013208056 hasConceptScore W2013208056C2778938600 @default.
- W2013208056 hasConceptScore W2013208056C2779459141 @default.
- W2013208056 hasConceptScore W2013208056C486523 @default.
- W2013208056 hasConceptScore W2013208056C513476851 @default.
- W2013208056 hasConceptScore W2013208056C55493867 @default.
- W2013208056 hasConceptScore W2013208056C71240020 @default.
- W2013208056 hasConceptScore W2013208056C71924100 @default.
- W2013208056 hasConceptScore W2013208056C98274493 @default.
- W2013208056 hasIssue "21" @default.
- W2013208056 hasLocation W20132080561 @default.
- W2013208056 hasLocation W20132080562 @default.
- W2013208056 hasOpenAccess W2013208056 @default.
- W2013208056 hasPrimaryLocation W20132080561 @default.
- W2013208056 hasRelatedWork W1480993038 @default.
- W2013208056 hasRelatedWork W1976682355 @default.
- W2013208056 hasRelatedWork W1981748579 @default.
- W2013208056 hasRelatedWork W1993614295 @default.
- W2013208056 hasRelatedWork W1998746685 @default.
- W2013208056 hasRelatedWork W2013208056 @default.
- W2013208056 hasRelatedWork W2026353424 @default.
- W2013208056 hasRelatedWork W2045726405 @default.
- W2013208056 hasRelatedWork W2055691188 @default.
- W2013208056 hasRelatedWork W2083948707 @default.
- W2013208056 hasVolume "30" @default.
- W2013208056 isParatext "false" @default.
- W2013208056 isRetracted "false" @default.
- W2013208056 magId "2013208056" @default.
- W2013208056 workType "article" @default.