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• W2013209042 abstract "Several lines of evidence suggest that a hypoglutamatergic condition may induce a phenotypic loss of cortical parvalbumin (PV)-positive GABAergic interneurons, such as that observed in brain tissue of schizophrenic subjects. However, it is not known whether the loss of PV interneurons is a consequence of the hypoglutamatergic condition or a secondary aspect of the disease. We characterized the signaling and subunit expression of NMDA receptors in cultured cortical PV interneurons and determined whether a hypoglutamatergic condition, created by direct application of sublethal concentrations of ketamine or subunit-selective NMDA receptor antagonists, can affect the expression of the GABAergic markers as observed in vivo . Real-time PCR performed on mRNA isolated from single neurons showed that PV interneurons present a fivefold higher NR2A/NR2B ratio than pyramidal neurons. Brief, nontoxic, exposure to NMDA led to an increase in ERK1/2 (extracellular signal-regulated kinase 1/2) and cAMP response element-binding protein phosphorylation in PV interneurons, and this increase was blocked by the NR2A-selective antagonist NVP-AAM077. Application of the nonselective NMDA receptor antagonist ketamine, at sublethal concentrations, induced a time and dose-dependent decrease in parvalbumin and GAD67 immunoreactivity specifically in PV interneurons. These effects were reversible and were also observed with the NR2A-selective antagonist, whereas the NR2B-selective antagonist Ro-25-6981 only partially reduced GAD67 immunoreactivity. Coexposure to the calcium channel opener BayK, or the group I metabotropic glutamate receptor agonist DHPG [( RS )-3,5-dihydroxyphenylglycine] attenuated the decrease in GAD67 and parvalbumin induced by the NMDA receptor antagonists. These results suggest that the activity of NR2A-containing NMDA receptors play a pivotal role in the maintenance of the GABAergic function of PV interneurons." @default.
• W2013209042 created "2016-06-24" @default.
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• W2013209042 date "2006-02-01" @default.
• W2013209042 modified "2023-10-18" @default.
• W2013209042 title "A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons" @default.
• W2013209042 cites W1211088797 @default.
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• W2013209042 cites W1631738930 @default.
• W2013209042 cites W1667466682 @default.
• W2013209042 cites W1927904330 @default.
• W2013209042 cites W1960073700 @default.
• W2013209042 cites W1968840456 @default.
• W2013209042 cites W1972812522 @default.
• W2013209042 cites W1973436856 @default.
• W2013209042 cites W1973845468 @default.
• W2013209042 cites W1977938288 @default.
• W2013209042 cites W1979822513 @default.
• W2013209042 cites W1979841513 @default.
• W2013209042 cites W1980527519 @default.
• W2013209042 cites W1988532274 @default.
• W2013209042 cites W1989740203 @default.
• W2013209042 cites W1991444172 @default.
• W2013209042 cites W1995079626 @default.
• W2013209042 cites W1995680954 @default.
• W2013209042 cites W2005797241 @default.
• W2013209042 cites W2014551551 @default.
• W2013209042 cites W2015807826 @default.
• W2013209042 cites W2017706994 @default.
• W2013209042 cites W2020924958 @default.
• W2013209042 cites W2021922794 @default.
• W2013209042 cites W2032208151 @default.
• W2013209042 cites W2032529587 @default.
• W2013209042 cites W2032596004 @default.
• W2013209042 cites W2041024256 @default.
• W2013209042 cites W2041848975 @default.
• W2013209042 cites W2044598463 @default.
• W2013209042 cites W2046539677 @default.
• W2013209042 cites W2048250261 @default.
• W2013209042 cites W2064310011 @default.
• W2013209042 cites W2065169750 @default.
• W2013209042 cites W2067669919 @default.
• W2013209042 cites W2070744786 @default.
• W2013209042 cites W2078282208 @default.
• W2013209042 cites W2078660236 @default.
• W2013209042 cites W2084120702 @default.
• W2013209042 cites W2084328300 @default.
• W2013209042 cites W2084639805 @default.
• W2013209042 cites W2088081549 @default.
• W2013209042 cites W2089912569 @default.
• W2013209042 cites W2093048200 @default.
• W2013209042 cites W2093248761 @default.
• W2013209042 cites W2098233668 @default.
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• W2013209042 doi "https://doi.org/10.1523/jneurosci.4722-05.2006" @default.
• W2013209042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6675509" @default.
• W2013209042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16452684" @default.
• W2013209042 hasPublicationYear "2006" @default.
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