FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013216314> ?p ?o ?g. }

• W2013216314 endingPage "3615" @default.
• W2013216314 startingPage "3604" @default.
• W2013216314 abstract "Acetyl-11-keto-beta-boswellic acid (AKBA) is a derivative of boswellic acid, an active component of Boswellia serrata gum resin. We examined the effect of AKBA on human gastric carcinoma growth and explored the underlying molecular mechanisms.Inhibition of cancer cell growth was estimated by colorimetric and clonogenic assays. Cell cycle distribution was analyzed by flow cytometry and apoptosis determined using Annexin V-FITC/PI staining and DNA ladder quantification. After three weeks of oral AKBA administration in nude mice bearing cancer xenografts, animals were sacrificed and xenografts removed for TUNEL staining and western blot analysis.AKBA exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity. This effect might be associated with its roles in cell cycle arrest and apoptosis induction. The results also showed activation of p21(Waf1/Cip1) and p53 in mitochondria and increased cleaved caspase-9, caspase-3, and PARP and Bax/Bcl-2 ratio after AKBA treatment. Further analysis suggested that these effects might arise from AKBA's modulation of the aberrant Wnt/β-catenin signaling pathway. Upon AKBA treatment, β-catenin expression in nuclei was inhibited, and membrane β-catenin was activated. In the same sample, active GSK3β was increased and its non-active form decreased. Levels of cyclin D1, PCNA, survivin, c-Myc, MMP-2, and MMP-7, downstream targets of Wnt/β-catenin, were inhibited.AKBA effects on human gastric carcinoma growth were associated with its activity in modulating the Wnt/β-catenin signaling pathway.AKBA could be useful in the treatment of gastric cancers." @default.
• W2013216314 created "2016-06-24" @default.
• W2013216314 creator A5004949415 @default.
• W2013216314 creator A5009051844 @default.
• W2013216314 creator A5020872682 @default.
• W2013216314 creator A5044400826 @default.
• W2013216314 creator A5046123355 @default.
• W2013216314 creator A5050840588 @default.
• W2013216314 creator A5057948519 @default.
• W2013216314 creator A5061388769 @default.
• W2013216314 creator A5063688854 @default.
• W2013216314 date "2013-06-01" @default.
• W2013216314 modified "2023-10-18" @default.
• W2013216314 title "RETRACTED: Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway" @default.
• W2013216314 cites W1964387778 @default.
• W2013216314 cites W1967132787 @default.
• W2013216314 cites W1977071537 @default.
• W2013216314 cites W1981273298 @default.
• W2013216314 cites W1983710466 @default.
• W2013216314 cites W1983718303 @default.
• W2013216314 cites W1985516721 @default.
• W2013216314 cites W1985997088 @default.
• W2013216314 cites W1986387604 @default.
• W2013216314 cites W1994450998 @default.
• W2013216314 cites W1996621745 @default.
• W2013216314 cites W1996916516 @default.
• W2013216314 cites W1999479793 @default.
• W2013216314 cites W2002219266 @default.
• W2013216314 cites W2004100213 @default.
• W2013216314 cites W2010624503 @default.
• W2013216314 cites W2013361898 @default.
• W2013216314 cites W2018965952 @default.
• W2013216314 cites W2026049398 @default.
• W2013216314 cites W2035780664 @default.
• W2013216314 cites W2036961594 @default.
• W2013216314 cites W2037252818 @default.
• W2013216314 cites W2039227324 @default.
• W2013216314 cites W2046613720 @default.
• W2013216314 cites W2055053845 @default.
• W2013216314 cites W2073650503 @default.
• W2013216314 cites W2080331552 @default.
• W2013216314 cites W2084175358 @default.
• W2013216314 cites W2088210361 @default.
• W2013216314 cites W2092763176 @default.
• W2013216314 cites W2098953499 @default.
• W2013216314 cites W2101434677 @default.
• W2013216314 cites W2102517422 @default.
• W2013216314 cites W2114756845 @default.
• W2013216314 cites W2118109822 @default.
• W2013216314 cites W2132057054 @default.
• W2013216314 cites W2139124195 @default.
• W2013216314 cites W2139328195 @default.
• W2013216314 cites W2143964191 @default.
• W2013216314 cites W2149527076 @default.
• W2013216314 cites W2156250680 @default.
• W2013216314 cites W2157854594 @default.
• W2013216314 cites W1980527831 @default.
• W2013216314 cites W2405794975 @default.
• W2013216314 doi "https://doi.org/10.1016/j.bbagen.2013.03.003" @default.
• W2013216314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23500016" @default.
• W2013216314 hasPublicationYear "2013" @default.
• W2013216314 type Work @default.
• W2013216314 sameAs 2013216314 @default.
• W2013216314 citedByCount "21" @default.
• W2013216314 countsByYear W20132163142013 @default.
• W2013216314 countsByYear W20132163142014 @default.
• W2013216314 countsByYear W20132163142015 @default.
• W2013216314 countsByYear W20132163142016 @default.
• W2013216314 countsByYear W20132163142017 @default.
• W2013216314 countsByYear W20132163142019 @default.
• W2013216314 countsByYear W20132163142020 @default.
• W2013216314 countsByYear W20132163142023 @default.
• W2013216314 crossrefType "journal-article" @default.
• W2013216314 hasAuthorship W2013216314A5004949415 @default.
• W2013216314 hasAuthorship W2013216314A5009051844 @default.
• W2013216314 hasAuthorship W2013216314A5020872682 @default.
• W2013216314 hasAuthorship W2013216314A5044400826 @default.
• W2013216314 hasAuthorship W2013216314A5046123355 @default.
• W2013216314 hasAuthorship W2013216314A5050840588 @default.
• W2013216314 hasAuthorship W2013216314A5057948519 @default.
• W2013216314 hasAuthorship W2013216314A5061388769 @default.
• W2013216314 hasAuthorship W2013216314A5063688854 @default.
• W2013216314 hasConcept C117262875 @default.
• W2013216314 hasConcept C137620995 @default.
• W2013216314 hasConcept C153911025 @default.
• W2013216314 hasConcept C185592680 @default.
• W2013216314 hasConcept C190283241 @default.
• W2013216314 hasConcept C199835354 @default.
• W2013216314 hasConcept C2775975398 @default.
• W2013216314 hasConcept C29537977 @default.
• W2013216314 hasConcept C502942594 @default.
• W2013216314 hasConcept C55493867 @default.
• W2013216314 hasConcept C62112901 @default.
• W2013216314 hasConcept C62478195 @default.
• W2013216314 hasConcept C86803240 @default.
• W2013216314 hasConceptScore W2013216314C117262875 @default.
• W2013216314 hasConceptScore W2013216314C137620995 @default.
• W2013216314 hasConceptScore W2013216314C153911025 @default.

• next