FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013217473> ?p ?o ?g. }

• W2013217473 endingPage "129" @default.
• W2013217473 startingPage "117" @default.
• W2013217473 abstract "We investigated the roles of A1, A2A, or A3 receptors and purine salvage in cardioprotection with exogenous adenosine, and tested whether A2A -mediated reductions in perfusion pressure modify post-ischemic recovery. Treatment with 10(-5) or 5 x 10(-5) M adenosine improved contractile recovery from 20 min ischemia 45 min reperfusion in isolated mouse hearts. Protection was attenuated by adenosine kinase inhibition (10(-5) M iodotubercidin) and receptor antagonism (5 x 10(-5) M 8-rho-sulfophenyltheophylline, 8-SPT). Enzyme efflux mirrored contractile recoveries. A 3 agonism with 10(-7) M 2-chloro- N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) improved ischemic tolerance whereas A1 agonism with 5 x 10(-8) M N6-cyclopentyladenosine (CPA) and A2A agonism with 10(-9) M 2-[p-(2-carboxyethyl) phenethylamino]-5'-N-ethylcarboxamidoadenosine (CGS21680) or 2 x 10(-8) M methyl-4-(3-[9-[4S,5S,2R,3R)-5-(N-ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]-6-aminopurin-2-yl)]prop-2-ynyl) cyclohexane-carboxylate (ATL-146e) were ineffective. Protection via A1 receptor overexpression was enhanced by adenosine, but unaltered by A1 or A2A agonists. Finally, post-ischemic dysfunction in hearts perfused at constant flow was dependent on coronary pressure, with A2A AR-mediated reductions in pressure reducing diastolic contracture, and elevated perfusion pressure worsening contracture. Data indicate that cardioprotection with exogenous adenosine in asanguinous hearts involves purine salvage and activation of A3 but not A1 or A2A receptors." @default.
• W2013217473 created "2016-06-24" @default.
• W2013217473 creator A5004008884 @default.
• W2013217473 creator A5025561543 @default.
• W2013217473 creator A5047274084 @default.
• W2013217473 creator A5065208290 @default.
• W2013217473 creator A5085172858 @default.
• W2013217473 date "2002-01-01" @default.
• W2013217473 modified "2023-09-25" @default.
• W2013217473 title "Adenosine-Mediated Cardioprotection in Ischemic-Reperfused Mouse Heart" @default.
• W2013217473 cites W1537684840 @default.
• W2013217473 cites W17652517 @default.
• W2013217473 cites W1967141148 @default.
• W2013217473 cites W1970592808 @default.
• W2013217473 cites W1971381575 @default.
• W2013217473 cites W1973160550 @default.
• W2013217473 cites W1977966461 @default.
• W2013217473 cites W1988015840 @default.
• W2013217473 cites W1989214210 @default.
• W2013217473 cites W1993111915 @default.
• W2013217473 cites W1997018092 @default.
• W2013217473 cites W1997299202 @default.
• W2013217473 cites W2002357831 @default.
• W2013217473 cites W2004999698 @default.
• W2013217473 cites W2008952071 @default.
• W2013217473 cites W2012082840 @default.
• W2013217473 cites W2028804351 @default.
• W2013217473 cites W2030362313 @default.
• W2013217473 cites W2044596153 @default.
• W2013217473 cites W2045692189 @default.
• W2013217473 cites W2064044397 @default.
• W2013217473 cites W2066095390 @default.
• W2013217473 cites W2067609325 @default.
• W2013217473 cites W2076415090 @default.
• W2013217473 cites W2077119701 @default.
• W2013217473 cites W2077747679 @default.
• W2013217473 cites W2086807993 @default.
• W2013217473 cites W2091686578 @default.
• W2013217473 cites W2120072968 @default.
• W2013217473 cites W2125947282 @default.
• W2013217473 cites W2132279779 @default.
• W2013217473 cites W2147817917 @default.
• W2013217473 cites W2156137650 @default.
• W2013217473 cites W2159193479 @default.
• W2013217473 cites W2159893444 @default.
• W2013217473 cites W2162105049 @default.
• W2013217473 cites W2163982472 @default.
• W2013217473 cites W2169920833 @default.
• W2013217473 cites W2169972706 @default.
• W2013217473 cites W2170983765 @default.
• W2013217473 cites W2207688454 @default.
• W2013217473 cites W2225113095 @default.
• W2013217473 cites W2279475009 @default.
• W2013217473 cites W2327778167 @default.
• W2013217473 cites W2333153638 @default.
• W2013217473 cites W2410378947 @default.
• W2013217473 cites W2416201391 @default.
• W2013217473 cites W327147448 @default.
• W2013217473 doi "https://doi.org/10.1097/00005344-200201000-00013" @default.
• W2013217473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11743234" @default.
• W2013217473 hasPublicationYear "2002" @default.
• W2013217473 type Work @default.
• W2013217473 sameAs 2013217473 @default.
• W2013217473 citedByCount "60" @default.
• W2013217473 countsByYear W20132174732012 @default.
• W2013217473 countsByYear W20132174732013 @default.
• W2013217473 countsByYear W20132174732016 @default.
• W2013217473 countsByYear W20132174732017 @default.
• W2013217473 countsByYear W20132174732019 @default.
• W2013217473 countsByYear W20132174732022 @default.
• W2013217473 countsByYear W20132174732023 @default.
• W2013217473 crossrefType "journal-article" @default.
• W2013217473 hasAuthorship W2013217473A5004008884 @default.
• W2013217473 hasAuthorship W2013217473A5025561543 @default.
• W2013217473 hasAuthorship W2013217473A5047274084 @default.
• W2013217473 hasAuthorship W2013217473A5065208290 @default.
• W2013217473 hasAuthorship W2013217473A5085172858 @default.
• W2013217473 hasConcept C126322002 @default.
• W2013217473 hasConcept C134018914 @default.
• W2013217473 hasConcept C158424129 @default.
• W2013217473 hasConcept C170493617 @default.
• W2013217473 hasConcept C182683403 @default.
• W2013217473 hasConcept C185592680 @default.
• W2013217473 hasConcept C2776991684 @default.
• W2013217473 hasConcept C2778491162 @default.
• W2013217473 hasConcept C2778938600 @default.
• W2013217473 hasConcept C2779311647 @default.
• W2013217473 hasConcept C2779676291 @default.
• W2013217473 hasConcept C541997718 @default.
• W2013217473 hasConcept C67907053 @default.
• W2013217473 hasConcept C71924100 @default.
• W2013217473 hasConcept C98274493 @default.
• W2013217473 hasConceptScore W2013217473C126322002 @default.
• W2013217473 hasConceptScore W2013217473C134018914 @default.
• W2013217473 hasConceptScore W2013217473C158424129 @default.
• W2013217473 hasConceptScore W2013217473C170493617 @default.
• W2013217473 hasConceptScore W2013217473C182683403 @default.
• W2013217473 hasConceptScore W2013217473C185592680 @default.

• next