FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013219672> ?p ?o ?g. }

• W2013219672 endingPage "898" @default.
• W2013219672 startingPage "886" @default.
• W2013219672 abstract "Two type I interferon (IFN) genes, designated as rbIFN1 and rbIFN2, have been cloned and characterized in rock bream. They are both comprised of 5 exons and 4 introns, and are closely linked on the rock bream chromosome in a unique head-to-head configuration. Both genes encode 183 amino acid (aa) precursor with a putative 17 aa signal peptide in the N-terminal. Only one amino acid divergence is present between two IFNs. Compared with the type I IFNs in higher vertebrates, two rock bream IFNs possess conserved alpha helical structure and share approximately 20% identity in aa sequence. The highest aa sequence homology (83.2%) was found with European seabass IFNs. Phylogenetic analysis grouped two rock bream IFNs into the subgroup-d of two-cysteine containing IFNs. The gene synteny analysis revealed that they are orthologous with the zebrafish IFNφ4 on chromosome-12 and paralogous to each other, which are likely derived from a gene duplication event followed by an inversion. A number of cis-regulatory elements associated with immune response including 15 IRF and 6 NF-κB binding sites are predicted in the shared 4.5 kb 5’-flanking region. Highest constitutive expression of two IFNs was detected in blood cells and skin. Their expression in blood cells and head kidney was up-regulated by lipopolysaccharide, poly I:C, Edwardsiella tarda, Streptococcus iniae and iridovirus. Furthermore, recombinant rbIFN1 protein produced by E. coli induced a rapid and transient expression of the interferon inducible Mx gene in head kidney cells. These results suggest that two duplicated type I IFN genes are involved in rock bream host response to both viral and bacterial pathogens." @default.
• W2013219672 created "2016-06-24" @default.
• W2013219672 creator A5004097270 @default.
• W2013219672 creator A5030480121 @default.
• W2013219672 creator A5031163028 @default.
• W2013219672 creator A5032637617 @default.
• W2013219672 creator A5038563397 @default.
• W2013219672 creator A5058672519 @default.
• W2013219672 creator A5065315410 @default.
• W2013219672 creator A5078515384 @default.
• W2013219672 creator A5089783467 @default.
• W2013219672 date "2012-10-01" @default.
• W2013219672 modified "2023-10-03" @default.
• W2013219672 title "Molecular cloning and functional characterization of two duplicated two-cysteine containing type I interferon genes in rock bream Oplegnathus fasciatus" @default.
• W2013219672 cites W1497703128 @default.
• W2013219672 cites W1556251771 @default.
• W2013219672 cites W1707550274 @default.
• W2013219672 cites W1733534154 @default.
• W2013219672 cites W1888489312 @default.
• W2013219672 cites W1959752861 @default.
• W2013219672 cites W1964271390 @default.
• W2013219672 cites W1973405995 @default.
• W2013219672 cites W1980947510 @default.
• W2013219672 cites W1984167622 @default.
• W2013219672 cites W1991702331 @default.
• W2013219672 cites W1997767982 @default.
• W2013219672 cites W2004563187 @default.
• W2013219672 cites W2005884645 @default.
• W2013219672 cites W2013433092 @default.
• W2013219672 cites W2017784906 @default.
• W2013219672 cites W2029706883 @default.
• W2013219672 cites W2032136357 @default.
• W2013219672 cites W2041309209 @default.
• W2013219672 cites W2042207745 @default.
• W2013219672 cites W2045584477 @default.
• W2013219672 cites W2046199885 @default.
• W2013219672 cites W2053164681 @default.
• W2013219672 cites W2055151525 @default.
• W2013219672 cites W2061881258 @default.
• W2013219672 cites W2066439964 @default.
• W2013219672 cites W2071175383 @default.
• W2013219672 cites W2074765204 @default.
• W2013219672 cites W2078193369 @default.
• W2013219672 cites W2078619682 @default.
• W2013219672 cites W2078844752 @default.
• W2013219672 cites W2081953196 @default.
• W2013219672 cites W2082889122 @default.
• W2013219672 cites W2085237060 @default.
• W2013219672 cites W2086164999 @default.
• W2013219672 cites W2089077517 @default.
• W2013219672 cites W2100396313 @default.
• W2013219672 cites W2102363834 @default.
• W2013219672 cites W2109523152 @default.
• W2013219672 cites W2111724750 @default.
• W2013219672 cites W2112292838 @default.
• W2013219672 cites W2115528382 @default.
• W2013219672 cites W2115865785 @default.
• W2013219672 cites W2116894829 @default.
• W2013219672 cites W2119787668 @default.
• W2013219672 cites W2119885778 @default.
• W2013219672 cites W2123026728 @default.
• W2013219672 cites W2125121305 @default.
• W2013219672 cites W2148154918 @default.
• W2013219672 cites W2156458491 @default.
• W2013219672 cites W2235894312 @default.
• W2013219672 doi "https://doi.org/10.1016/j.fsi.2012.07.018" @default.
• W2013219672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22889848" @default.
• W2013219672 hasPublicationYear "2012" @default.
• W2013219672 type Work @default.
• W2013219672 sameAs 2013219672 @default.
• W2013219672 citedByCount "38" @default.
• W2013219672 countsByYear W20132196722013 @default.
• W2013219672 countsByYear W20132196722014 @default.
• W2013219672 countsByYear W20132196722015 @default.
• W2013219672 countsByYear W20132196722016 @default.
• W2013219672 countsByYear W20132196722017 @default.
• W2013219672 countsByYear W20132196722018 @default.
• W2013219672 countsByYear W20132196722019 @default.
• W2013219672 countsByYear W20132196722020 @default.
• W2013219672 countsByYear W20132196722021 @default.
• W2013219672 countsByYear W20132196722022 @default.
• W2013219672 countsByYear W20132196722023 @default.
• W2013219672 crossrefType "journal-article" @default.
• W2013219672 hasAuthorship W2013219672A5004097270 @default.
• W2013219672 hasAuthorship W2013219672A5030480121 @default.
• W2013219672 hasAuthorship W2013219672A5031163028 @default.
• W2013219672 hasAuthorship W2013219672A5032637617 @default.
• W2013219672 hasAuthorship W2013219672A5038563397 @default.
• W2013219672 hasAuthorship W2013219672A5058672519 @default.
• W2013219672 hasAuthorship W2013219672A5065315410 @default.
• W2013219672 hasAuthorship W2013219672A5078515384 @default.
• W2013219672 hasAuthorship W2013219672A5089783467 @default.
• W2013219672 hasConcept C104317684 @default.
• W2013219672 hasConcept C153911025 @default.
• W2013219672 hasConcept C167625842 @default.
• W2013219672 hasConcept C2776832872 @default.
• W2013219672 hasConcept C2776878037 @default.
• W2013219672 hasConcept C2778873838 @default.

• next