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- W2013222621 abstract "Abstract Base sequence homology between PR8 segment 4, the gene coding for the hemagglutinin, and the cRNAs of other influenza A prototype strains was determined. One hundred percent base sequence homology was found between PR8 (HO) and FMl (Hl), and 80% homology between PR8 and swine influenza virus (HSW1), although there is no cross-inhibition of hemagglutination. This is in clear contrast to other antigenically unrelated strains, which exhibit a base sequence homology between 20 and 40% with regard to segment 4. Fowl plague virus (FPV) and the Dutch strain, and equine 2 virus and the Hong Kong strain, which have antigenically related hemagglutinins, exhibit a base sequence homology of 100 and 80%, respectively. The available data suggest that swine, PR8, and FMl comprise one “subtype” genetically and are not derived by recombination, but differ by a number of point mutations." @default.
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- W2013222621 date "1977-06-01" @default.
- W2013222621 modified "2023-09-26" @default.
- W2013222621 title "Correlation between base sequence homology of RNA segment 4 and antigenicity of the hemagglutinin of influenza viruses" @default.
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- W2013222621 doi "https://doi.org/10.1016/0042-6822(77)90360-9" @default.
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