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• W2013224236 abstract "This paper describes the high-throughput proteomic analysis of the dorsolateral prefrontal cortex (DLPFC) from schizophrenia (SCHIZ), bipolar (BD), and normal control cohorts from the Harvard Brain Tissue Resource Center performed using ProteinChip technology based on the surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS). The resultant profiles were utilized in classification-tree algorithms for selection of protein biomarker peaks contributing maximally to the differentiation between the examined diagnostic cohorts. Twenty-four such protein biomarker peaks were identified. All of them had lower levels in the SCHIZ cohort as compared to the BD cohort. Also, 21 of these peaks were down-regulated in the SCHIZ cohort vs. the control cohort, and 7 peaks were up-regulated in the BD cohort vs. the control cohort. The proteins constituting these biomarker peaks were recognized via matrix-assisted laser desorption time of flight/postsource decay mass spectrometry (MALDI-TOF-PSD-MS). These proteins represent a wide range of functional groups involved in cell metabolism, signaling cascades, regulation of gene transcription, protein and RNA chaperoning, and other aspects of cellular homeostasis. Finally, after statistical evaluation suggesting that the selected protein biomarkers are not significantly impacted by epidemiological/tissue storage parameters (although, influence of antipsychotic and mood stabilizing drugs could not be fully excluded), the ProteinChip-based profiling was engaged again to demonstrate that the detected SCHIZ-associated changes in the levels of our protein biomarkers could also be seen in DLPFC samples from the brain collection of the Mount Sinai Medical School/Bronx Veteran Affairs Medical Center. This study demonstrates the usefulness of ProteinChip-based SELDI-TOF protein profiling in gaining insight into the molecular pathology of SCHIZ and BD as it points to changes in protein levels characterizing these diseases." @default.
• W2013224236 created "2016-06-24" @default.
• W2013224236 creator A5013120307 @default.
• W2013224236 creator A5062036694 @default.
• W2013224236 creator A5073325036 @default.
• W2013224236 creator A5081629015 @default.
• W2013224236 date "2006-07-01" @default.
• W2013224236 modified "2023-09-26" @default.
• W2013224236 title "Identification of protein biomarkers for schizophrenia and bipolar disorder in the postmortem prefrontal cortex using SELDI-TOF-MS ProteinChip profiling combined with MALDI-TOF-PSD-MS analysis" @default.
• W2013224236 cites W1732798991 @default.
• W2013224236 cites W179325704 @default.
• W2013224236 cites W1937618727 @default.
• W2013224236 cites W1954801073 @default.
• W2013224236 cites W1964841325 @default.
• W2013224236 cites W1964850060 @default.
• W2013224236 cites W1968447063 @default.
• W2013224236 cites W1969993637 @default.
• W2013224236 cites W1971034684 @default.
• W2013224236 cites W1971956967 @default.
• W2013224236 cites W1977638003 @default.
• W2013224236 cites W1980926257 @default.
• W2013224236 cites W1989568022 @default.
• W2013224236 cites W1991503782 @default.
• W2013224236 cites W1992876329 @default.
• W2013224236 cites W1996612692 @default.
• W2013224236 cites W1997815735 @default.
• W2013224236 cites W2002397068 @default.
• W2013224236 cites W2006952836 @default.
• W2013224236 cites W2009006606 @default.
• W2013224236 cites W2009799633 @default.
• W2013224236 cites W2015760775 @default.
• W2013224236 cites W2016675737 @default.
• W2013224236 cites W2021167502 @default.
• W2013224236 cites W2023152559 @default.
• W2013224236 cites W2024770693 @default.
• W2013224236 cites W2032208151 @default.
• W2013224236 cites W2034832743 @default.
• W2013224236 cites W2041787007 @default.
• W2013224236 cites W2042054309 @default.
• W2013224236 cites W2042267614 @default.
• W2013224236 cites W2044291712 @default.
• W2013224236 cites W2047632234 @default.
• W2013224236 cites W2050594129 @default.
• W2013224236 cites W2051830951 @default.
• W2013224236 cites W2053159677 @default.
• W2013224236 cites W2058760936 @default.
• W2013224236 cites W2063112284 @default.
• W2013224236 cites W2065094079 @default.
• W2013224236 cites W2072529095 @default.
• W2013224236 cites W2074040050 @default.
• W2013224236 cites W2075000499 @default.
• W2013224236 cites W2075398614 @default.
• W2013224236 cites W2075561696 @default.
• W2013224236 cites W2078502857 @default.
• W2013224236 cites W2084062025 @default.
• W2013224236 cites W2084275797 @default.
• W2013224236 cites W2088001693 @default.
• W2013224236 cites W2090207532 @default.
• W2013224236 cites W2090861097 @default.
• W2013224236 cites W2090962387 @default.
• W2013224236 cites W2094970290 @default.
• W2013224236 cites W2097417059 @default.
• W2013224236 cites W2104275576 @default.
• W2013224236 cites W2105017286 @default.
• W2013224236 cites W2105097410 @default.
• W2013224236 cites W2107363136 @default.
• W2013224236 cites W2108725536 @default.
• W2013224236 cites W2109354517 @default.
• W2013224236 cites W2110008349 @default.
• W2013224236 cites W2112411667 @default.
• W2013224236 cites W2112522183 @default.
• W2013224236 cites W2115039568 @default.
• W2013224236 cites W2117217305 @default.
• W2013224236 cites W2122430069 @default.
• W2013224236 cites W2139155172 @default.
• W2013224236 cites W2141009231 @default.
• W2013224236 cites W2143080892 @default.
• W2013224236 cites W2145025818 @default.
• W2013224236 cites W2150260045 @default.
• W2013224236 cites W2154540835 @default.
• W2013224236 cites W2158329357 @default.
• W2013224236 cites W2158986665 @default.
• W2013224236 cites W2159262602 @default.
• W2013224236 cites W2160385640 @default.
• W2013224236 cites W2161371306 @default.
• W2013224236 cites W2162821981 @default.
• W2013224236 cites W2168480206 @default.
• W2013224236 cites W2328048826 @default.
• W2013224236 cites W268023700 @default.
• W2013224236 cites W4205298449 @default.
• W2013224236 cites W4248355228 @default.
• W2013224236 cites W4256566150 @default.
• W2013224236 cites W4319425454 @default.
• W2013224236 cites W4322702033 @default.
• W2013224236 cites W72552325 @default.
• W2013224236 doi "https://doi.org/10.1016/j.nbd.2006.02.002" @default.
• W2013224236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16549361" @default.
• W2013224236 hasPublicationYear "2006" @default.

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