Matches in SemOpenAlex for { <https://semopenalex.org/work/W201322437> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W201322437 abstract "Background: Perioperative myocardial injury (PMI) complicating cardiac surgery remains poorly predicted by clinical risk factors. In a novel rat model of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) we tested the hypothesis that microarray expression profiles in peripheral blood leukocytes (PBL) can accurately predict degree of PMI, and compared genomic signatures in left ventricular myocardium (LVM) and PBL to identify PMI-associated genes that generalize across tissues. Methods: Male rats subjected to CPB only (75 min), CPB with CA (30 min), and sham surgery (n=5 each) had plasma heart fatty acid binding protein (HFABP) and cardiac troponin I (cTnI) measured 1 hour post CPB and microarray profiling of total RNA from LVM and PBL. PMI genomic classification models were constructed using shotgun stochastic search approach and Bayesian model averaging and their accuracy tested by five-fold cross validation. Results: A spectrum of PMI was observed in the experimental groups as well as robust deregulation of gene expression in a stimulus and tissue-specific manner (Figure ). Estimates of PMI classification accuracy from PBL and LVM are presented in Table . Conclusions: Cardiac surgery induces changes in leukocyte gene expression that predict the spectrum of PMI, with potential applications in perioperative risk stratification and selection of cardioprotective strategies. Predictive accuracy of tissue-specific myocardial injury genomic classifiers" @default.
- W201322437 created "2016-06-24" @default.
- W201322437 creator A5005513797 @default.
- W201322437 creator A5042241327 @default.
- W201322437 creator A5051195956 @default.
- W201322437 creator A5053490576 @default.
- W201322437 creator A5063883837 @default.
- W201322437 creator A5079879863 @default.
- W201322437 date "2007-10-16" @default.
- W201322437 modified "2023-09-26" @default.
- W201322437 title "Abstract 1553: Comparative Gene Expression Analysis of Blood and Heart Identifies Genomic Predictors of Myocardial Injury Following Cardiopulmonary Bypass and Cardioplegic Arrest in the Rat" @default.
- W201322437 doi "https://doi.org/10.1161/circ.116.suppl_16.ii_323" @default.
- W201322437 hasPublicationYear "2007" @default.
- W201322437 type Work @default.
- W201322437 sameAs 201322437 @default.
- W201322437 citedByCount "0" @default.
- W201322437 crossrefType "journal-article" @default.
- W201322437 hasAuthorship W201322437A5005513797 @default.
- W201322437 hasAuthorship W201322437A5042241327 @default.
- W201322437 hasAuthorship W201322437A5051195956 @default.
- W201322437 hasAuthorship W201322437A5053490576 @default.
- W201322437 hasAuthorship W201322437A5063883837 @default.
- W201322437 hasAuthorship W201322437A5079879863 @default.
- W201322437 hasConcept C104317684 @default.
- W201322437 hasConcept C115725540 @default.
- W201322437 hasConcept C126322002 @default.
- W201322437 hasConcept C150194340 @default.
- W201322437 hasConcept C164705383 @default.
- W201322437 hasConcept C2778789114 @default.
- W201322437 hasConcept C2778881276 @default.
- W201322437 hasConcept C2779148672 @default.
- W201322437 hasConcept C31174226 @default.
- W201322437 hasConcept C36036425 @default.
- W201322437 hasConcept C42219234 @default.
- W201322437 hasConcept C500558357 @default.
- W201322437 hasConcept C55493867 @default.
- W201322437 hasConcept C71924100 @default.
- W201322437 hasConcept C86803240 @default.
- W201322437 hasConceptScore W201322437C104317684 @default.
- W201322437 hasConceptScore W201322437C115725540 @default.
- W201322437 hasConceptScore W201322437C126322002 @default.
- W201322437 hasConceptScore W201322437C150194340 @default.
- W201322437 hasConceptScore W201322437C164705383 @default.
- W201322437 hasConceptScore W201322437C2778789114 @default.
- W201322437 hasConceptScore W201322437C2778881276 @default.
- W201322437 hasConceptScore W201322437C2779148672 @default.
- W201322437 hasConceptScore W201322437C31174226 @default.
- W201322437 hasConceptScore W201322437C36036425 @default.
- W201322437 hasConceptScore W201322437C42219234 @default.
- W201322437 hasConceptScore W201322437C500558357 @default.
- W201322437 hasConceptScore W201322437C55493867 @default.
- W201322437 hasConceptScore W201322437C71924100 @default.
- W201322437 hasConceptScore W201322437C86803240 @default.
- W201322437 hasIssue "suppl_16" @default.
- W201322437 hasLocation W2013224371 @default.
- W201322437 hasOpenAccess W201322437 @default.
- W201322437 hasPrimaryLocation W2013224371 @default.
- W201322437 hasRelatedWork W1979404711 @default.
- W201322437 hasRelatedWork W1994037732 @default.
- W201322437 hasRelatedWork W2091872377 @default.
- W201322437 hasRelatedWork W2118578540 @default.
- W201322437 hasRelatedWork W2323995183 @default.
- W201322437 hasRelatedWork W2328729887 @default.
- W201322437 hasRelatedWork W2351427759 @default.
- W201322437 hasRelatedWork W2378163381 @default.
- W201322437 hasRelatedWork W2407372233 @default.
- W201322437 hasRelatedWork W2460375769 @default.
- W201322437 hasVolume "116" @default.
- W201322437 isParatext "false" @default.
- W201322437 isRetracted "false" @default.
- W201322437 magId "201322437" @default.
- W201322437 workType "article" @default.