FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013224863> ?p ?o ?g. }

• W2013224863 endingPage "455" @default.
• W2013224863 startingPage "445" @default.
• W2013224863 abstract "Background information. Many neurons secrete classical transmitters from synaptic vesicles as well as peptide transmitters from LDCVs (large dense-core vesicles). Little is known about the mechanistic differences between these two secretory pathways. The soluble protein Munc18-1 is essential for synaptic vesicle secretion [Verhage, Maia, Plomp, Brussaard, Heeroma, Vermeer, Toonen, Hammer, van den Berg, Missler, et al. (2000) Science 287, 864–869.]. Results. In the present study, we tested if Munc18 genes are also involved in peptidergic secretion from LDCVs using the anterior pituitary as a model system. We show that Munc18-1 is the dominant isoform expressed in the anterior pituitary. In Munc18-1 null mutant mice, the anterior pituitary developed normally and the five major endocrine cell types had a normal distribution. However, circulating peptide hormone levels were decreased by up to 50-fold in the null mutant, whereas the intracellular levels were significantly higher than that in controls. Ultrastructural analysis using the tannic acid method revealed striking differences in the distribution of secretory vesicles: (i) the number of exocytotic figures was mostly decreased in the null mutants and (ii) the LDCVs accumulated near but not at their target membrane. This is in contrast with the apparently normal distribution of synaptic vesicles in developing synapses in the null mutant (Verhage et al., 2000). Conclusions. We conclude that Munc18-1 is involved in the secretion of peptide hormones and in the docking of LDCVs. These results unmask an apparent mechanistic difference between LDCVs and synaptic vesicles." @default.
• W2013224863 created "2016-06-24" @default.
• W2013224863 creator A5020636822 @default.
• W2013224863 creator A5026872836 @default.
• W2013224863 creator A5028790221 @default.
• W2013224863 creator A5033101414 @default.
• W2013224863 creator A5067768806 @default.
• W2013224863 creator A5071016744 @default.
• W2013224863 date "2005-06-01" @default.
• W2013224863 modified "2023-09-27" @default.
• W2013224863 title "The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitary" @default.
• W2013224863 cites W1574617908 @default.
• W2013224863 cites W1822252127 @default.
• W2013224863 cites W1969036282 @default.
• W2013224863 cites W1980280188 @default.
• W2013224863 cites W1983009379 @default.
• W2013224863 cites W1992913172 @default.
• W2013224863 cites W1996645236 @default.
• W2013224863 cites W1996825158 @default.
• W2013224863 cites W2000718601 @default.
• W2013224863 cites W2004162860 @default.
• W2013224863 cites W2007266423 @default.
• W2013224863 cites W2019016101 @default.
• W2013224863 cites W2021070373 @default.
• W2013224863 cites W2024518000 @default.
• W2013224863 cites W2027840883 @default.
• W2013224863 cites W2028090135 @default.
• W2013224863 cites W2029091584 @default.
• W2013224863 cites W2032505434 @default.
• W2013224863 cites W2033797809 @default.
• W2013224863 cites W2036324000 @default.
• W2013224863 cites W2047137800 @default.
• W2013224863 cites W2047208143 @default.
• W2013224863 cites W2052999464 @default.
• W2013224863 cites W2059019606 @default.
• W2013224863 cites W2064109349 @default.
• W2013224863 cites W2069848841 @default.
• W2013224863 cites W2076548944 @default.
• W2013224863 cites W2083092470 @default.
• W2013224863 cites W2083555314 @default.
• W2013224863 cites W2088387899 @default.
• W2013224863 cites W2093467598 @default.
• W2013224863 cites W2103618752 @default.
• W2013224863 cites W2131204206 @default.
• W2013224863 cites W2131653836 @default.
• W2013224863 cites W2140926491 @default.
• W2013224863 cites W2154100802 @default.
• W2013224863 cites W2166322745 @default.
• W2013224863 cites W2170349574 @default.
• W2013224863 cites W2171466371 @default.
• W2013224863 cites W4234740815 @default.
• W2013224863 cites W4254508296 @default.
• W2013224863 doi "https://doi.org/10.1042/bc20040101" @default.
• W2013224863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15898951" @default.
• W2013224863 hasPublicationYear "2005" @default.
• W2013224863 type Work @default.
• W2013224863 sameAs 2013224863 @default.
• W2013224863 citedByCount "26" @default.
• W2013224863 countsByYear W20132248632017 @default.
• W2013224863 countsByYear W20132248632019 @default.
• W2013224863 countsByYear W20132248632020 @default.
• W2013224863 countsByYear W20132248632021 @default.
• W2013224863 countsByYear W20132248632022 @default.
• W2013224863 countsByYear W20132248632023 @default.
• W2013224863 crossrefType "journal-article" @default.
• W2013224863 hasAuthorship W2013224863A5020636822 @default.
• W2013224863 hasAuthorship W2013224863A5026872836 @default.
• W2013224863 hasAuthorship W2013224863A5028790221 @default.
• W2013224863 hasAuthorship W2013224863A5033101414 @default.
• W2013224863 hasAuthorship W2013224863A5067768806 @default.
• W2013224863 hasAuthorship W2013224863A5071016744 @default.
• W2013224863 hasBestOaLocation W20132248631 @default.
• W2013224863 hasConcept C126322002 @default.
• W2013224863 hasConcept C130316041 @default.
• W2013224863 hasConcept C134018914 @default.
• W2013224863 hasConcept C148785051 @default.
• W2013224863 hasConcept C175969161 @default.
• W2013224863 hasConcept C2779029589 @default.
• W2013224863 hasConcept C2909863526 @default.
• W2013224863 hasConcept C41625074 @default.
• W2013224863 hasConcept C49039625 @default.
• W2013224863 hasConcept C55493867 @default.
• W2013224863 hasConcept C71315377 @default.
• W2013224863 hasConcept C71924100 @default.
• W2013224863 hasConcept C86803240 @default.
• W2013224863 hasConcept C95444343 @default.
• W2013224863 hasConceptScore W2013224863C126322002 @default.
• W2013224863 hasConceptScore W2013224863C130316041 @default.
• W2013224863 hasConceptScore W2013224863C134018914 @default.
• W2013224863 hasConceptScore W2013224863C148785051 @default.
• W2013224863 hasConceptScore W2013224863C175969161 @default.
• W2013224863 hasConceptScore W2013224863C2779029589 @default.
• W2013224863 hasConceptScore W2013224863C2909863526 @default.
• W2013224863 hasConceptScore W2013224863C41625074 @default.
• W2013224863 hasConceptScore W2013224863C49039625 @default.
• W2013224863 hasConceptScore W2013224863C55493867 @default.
• W2013224863 hasConceptScore W2013224863C71315377 @default.
• W2013224863 hasConceptScore W2013224863C71924100 @default.

• next