FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013231408> ?p ?o ?g. }

• W2013231408 endingPage "407" @default.
• W2013231408 startingPage "397" @default.
• W2013231408 abstract "Summary The decay‐accelerating factor (DAF) prevents the intestinal mucosa from bystander killing by complement. Prostaglandin E 2 (PGE 2 ) induces the expression of DAF that may protect the tumour environment from complement attack. In the present study, we demonstrate synergistic actions of PGE 2 and two Krüppel‐like factors (KLFs), which are zinc finger‐containing transcription factors, in DAF regulation. Overexpression of KLF4 and KLF5 robustly induced transcriptional activity of the DAF promoter. In combination, PGE 2 and either KLF4 or KLF5 increased the expression of DAF in a synergistic fashion. Moreover, cyclooxygenase (COX‐1 and COX‐2) enzymes, KLF4/5 and DAF protein were coordinately expressed in normal intestinal mucosa as well as in intestinal neoplasm. In radiation‐injured mouse intestine, COX‐1 was rapidly induced and remained at relatively high levels. While KLF5 was quickly elevated after irradiation, KLF4 exhibited a delayed increase. Interestingly, levels of DAF increased gradually following the induction of COX‐1 and KLFs. Mimicking the circumstances in vivo , coexpression of both COX and KLFs resulted in a synergistic or additive induction of DAF transcription in intestinal epithelial cells. Our data suggest that COX‐derived PGE 2 may collaborate with KLF4/5 to regulate the activation of the complement system and exert diverse effects on the intestinal epithelium." @default.
• W2013231408 created "2016-06-24" @default.
• W2013231408 creator A5005959278 @default.
• W2013231408 creator A5035855141 @default.
• W2013231408 creator A5074509608 @default.
• W2013231408 date "2008-10-08" @default.
• W2013231408 modified "2023-10-16" @default.
• W2013231408 title "Prostaglandin E₂and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells" @default.
• W2013231408 cites W1576166191 @default.
• W2013231408 cites W1596657374 @default.
• W2013231408 cites W1648593433 @default.
• W2013231408 cites W1654950871 @default.
• W2013231408 cites W1764388483 @default.
• W2013231408 cites W1907479051 @default.
• W2013231408 cites W1968234999 @default.
• W2013231408 cites W1968537403 @default.
• W2013231408 cites W1977726195 @default.
• W2013231408 cites W1991728924 @default.
• W2013231408 cites W1991861950 @default.
• W2013231408 cites W1993818163 @default.
• W2013231408 cites W1995840777 @default.
• W2013231408 cites W1995889915 @default.
• W2013231408 cites W2009383010 @default.
• W2013231408 cites W2017344189 @default.
• W2013231408 cites W2020506330 @default.
• W2013231408 cites W2020797695 @default.
• W2013231408 cites W2024579029 @default.
• W2013231408 cites W2029793519 @default.
• W2013231408 cites W2032869210 @default.
• W2013231408 cites W2033869273 @default.
• W2013231408 cites W2039611809 @default.
• W2013231408 cites W2039971229 @default.
• W2013231408 cites W2040734194 @default.
• W2013231408 cites W2045049295 @default.
• W2013231408 cites W2048680922 @default.
• W2013231408 cites W2049821512 @default.
• W2013231408 cites W2051686420 @default.
• W2013231408 cites W2052200307 @default.
• W2013231408 cites W2060571271 @default.
• W2013231408 cites W2064552055 @default.
• W2013231408 cites W2072696221 @default.
• W2013231408 cites W2073738021 @default.
• W2013231408 cites W2074469807 @default.
• W2013231408 cites W2086747104 @default.
• W2013231408 cites W2087520237 @default.
• W2013231408 cites W2087633871 @default.
• W2013231408 cites W2087744847 @default.
• W2013231408 cites W2089895401 @default.
• W2013231408 cites W2094298465 @default.
• W2013231408 cites W2097997344 @default.
• W2013231408 cites W2104199760 @default.
• W2013231408 cites W2106360005 @default.
• W2013231408 cites W2109770898 @default.
• W2013231408 cites W2118523821 @default.
• W2013231408 cites W2126590121 @default.
• W2013231408 cites W2136588953 @default.
• W2013231408 cites W2140689375 @default.
• W2013231408 cites W2148459495 @default.
• W2013231408 cites W2149233326 @default.
• W2013231408 cites W2155195142 @default.
• W2013231408 cites W2163711719 @default.
• W2013231408 cites W2169661816 @default.
• W2013231408 cites W2169826337 @default.
• W2013231408 cites W2171996338 @default.
• W2013231408 cites W2181662501 @default.
• W2013231408 cites W2312652235 @default.
• W2013231408 doi "https://doi.org/10.1111/j.1365-2567.2008.02847.x" @default.
• W2013231408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2669143" @default.
• W2013231408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18435741" @default.
• W2013231408 hasPublicationYear "2008" @default.
• W2013231408 type Work @default.
• W2013231408 sameAs 2013231408 @default.
• W2013231408 citedByCount "13" @default.
• W2013231408 countsByYear W20132314082012 @default.
• W2013231408 countsByYear W20132314082013 @default.
• W2013231408 countsByYear W20132314082016 @default.
• W2013231408 countsByYear W20132314082019 @default.
• W2013231408 countsByYear W20132314082020 @default.
• W2013231408 countsByYear W20132314082022 @default.
• W2013231408 crossrefType "journal-article" @default.
• W2013231408 hasAuthorship W2013231408A5005959278 @default.
• W2013231408 hasAuthorship W2013231408A5035855141 @default.
• W2013231408 hasAuthorship W2013231408A5074509608 @default.
• W2013231408 hasBestOaLocation W20132314081 @default.
• W2013231408 hasConcept C104317684 @default.
• W2013231408 hasConcept C111684460 @default.
• W2013231408 hasConcept C126322002 @default.
• W2013231408 hasConcept C134018914 @default.
• W2013231408 hasConcept C153911025 @default.
• W2013231408 hasConcept C203014093 @default.
• W2013231408 hasConcept C2777198256 @default.
• W2013231408 hasConcept C2777933648 @default.
• W2013231408 hasConcept C2777956040 @default.
• W2013231408 hasConcept C2778265714 @default.
• W2013231408 hasConcept C2780664492 @default.
• W2013231408 hasConcept C2781077229 @default.
• W2013231408 hasConcept C3019368612 @default.
• W2013231408 hasConcept C502942594 @default.

• next