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• W2013232240 abstract "Immunoglobulin E (IgE)-mediated hypersensitivity against environmental allergens, commonly including Dermatophagoides farinae , is associated with atopic diseases in both humans and dogs. We have recently identified a family of clinically healthy West Highland white terriers (WHWTs) with high-serum D. farinae -IgE levels. In this study, we investigated the genetic mechanism controlling IgE responsiveness in dogs by performing a genome-wide association study (GWAS) using the Affymetrix V2 Dog SNP array in 31 high-IgE and 24 low-IgE responder WHWTs. A gene-dropping simulation method, using SIB-PAIR software, showed significant allelic association between serum D. farinae –specific IgE levels and a 2.3-Mb area on CFA35 (best empirical P = 1 × 10 –5 ). A nearby candidate gene, CD83 , encodes a protein which has important immunological functions in antigen presentation and regulation of humoral immune responses. We sequenced this gene in 2 high-IgE responders and 2 low-IgE responders and identified an intronic polymorphic repeat sequence with a predicted functional effect, but the association was insufficient to explain the GWAS association signal in this population ( P = 1 × 10 −3 ). Further studies are necessary to investigate the significance of these findings for IgE responsiveness and atopic disease in the dog." @default.
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• W2013232240 date "2011-08-16" @default.
• W2013232240 modified "2023-10-07" @default.
• W2013232240 title "IgE Responsiveness to Dermatophagoides farinae in West Highland White Terrier Dogs Is Associated with Region on CFA35" @default.
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• W2013232240 doi "https://doi.org/10.1093/jhered/esr054" @default.
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