FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W201323359> ?p ?o ?g. }

• W201323359 endingPage "132" @default.
• W201323359 startingPage "95" @default.
• W201323359 abstract "The kidneys are the major determinants of body water and electrolyte composition. Thus, comprehending the mechanisms of water transport is essential to understanding mammalian kidney physiology and water balance. Because of its importance to human health, water permeability has been particularly well characterized in the mammalian kidney (Knepper and Burg 1983). Approximately, 180L day−1 of glomerular filtrate is generated in an average adult human; more than 90% of this is constitutively reabsorbed by the highly water-permeable proximal tubules and descending thin limbs of Henle' loop. The ascending thin limbs and thick limbs are relatively impermeable to water and empty into renal distal tubules and ultimately into the collecting ducts. The collecting ducts are extremely important clinically in water-balance disorders, because they are the chief site of regulated water re-absorption. Basal epithelial water permeability in collecting duct principal cells is low, but the water permeability can become exceedingly high when stimulated with arginine vasopressin (AVP, also known as antidiuretic hormone (ADH)). In this regard, the toad urinary bladder behaves like the collecting duct, and it has served as an important model of vasopressin-regulated water permeability. Stimulation of this epithelium with vasopressin produces an increase in water permeability in the apical membrane, which coincides with the redistribution of intracellular particles to the cell surface (Kachadorian et al. 1975, 1977; Wade and Kachadorian 1988). These particles were believed to contain water channels. The discovery of aquaporin-1 (AQP1) by Agre and colleagues (Preston et al. 1992; Preston and Agre 1991; Smith and Agre 1991) explained the long-standing biophysical question of how water specifically crosses biological membranes, and these studies led to the identification of a whole new family of membrane proteins, the aquaporin water channels. At present, at least eight aquaporins are expressed at distinct sites in the kidney, and four members of this family (AQP1-4) have been demonstrated to play pivotal roles in the physiology and pathophysiology for renal regulation of body water balance. In the present review, we will focus on regulation of renal aquaporins and in particular how regulation of AQP2 takes place. In addition, a number of inherited and acquired conditions characterized by urinary concentration defects as well as common diseases associated with severe water retention are discussed with relation to the role of aquaporins in regulation and dysregulation of renal water transport." @default.
• W201323359 created "2016-06-24" @default.
• W201323359 creator A5033056096 @default.
• W201323359 creator A5055126904 @default.
• W201323359 creator A5072279663 @default.
• W201323359 creator A5081288829 @default.
• W201323359 creator A5085580540 @default.
• W201323359 creator A5088941482 @default.
• W201323359 date "2008-12-18" @default.
• W201323359 modified "2023-09-27" @default.
• W201323359 title "Aquaporins in the Kidney" @default.
• W201323359 cites W1501694644 @default.
• W201323359 cites W1576504870 @default.
• W201323359 cites W1580434367 @default.
• W201323359 cites W1595184644 @default.
• W201323359 cites W160047280 @default.
• W201323359 cites W1607563537 @default.
• W201323359 cites W1673860417 @default.
• W201323359 cites W1752750000 @default.
• W201323359 cites W1759023200 @default.
• W201323359 cites W1780008722 @default.
• W201323359 cites W1803508927 @default.
• W201323359 cites W1834646415 @default.
• W201323359 cites W1901287643 @default.
• W201323359 cites W1906135915 @default.
• W201323359 cites W1944772484 @default.
• W201323359 cites W1963570371 @default.
• W201323359 cites W1968156748 @default.
• W201323359 cites W1968374401 @default.
• W201323359 cites W1971990947 @default.
• W201323359 cites W1972946535 @default.
• W201323359 cites W1974003680 @default.
• W201323359 cites W1974587361 @default.
• W201323359 cites W1979993283 @default.
• W201323359 cites W1980044885 @default.
• W201323359 cites W1981069601 @default.
• W201323359 cites W1984284559 @default.
• W201323359 cites W1987518750 @default.
• W201323359 cites W1987560107 @default.
• W201323359 cites W1987781885 @default.
• W201323359 cites W1988009064 @default.
• W201323359 cites W1988506390 @default.
• W201323359 cites W1988585554 @default.
• W201323359 cites W1989940908 @default.
• W201323359 cites W1990042147 @default.
• W201323359 cites W1994198585 @default.
• W201323359 cites W1994266582 @default.
• W201323359 cites W1995419987 @default.
• W201323359 cites W1995624094 @default.
• W201323359 cites W1996633441 @default.
• W201323359 cites W1996896272 @default.
• W201323359 cites W1997671401 @default.
• W201323359 cites W1997813871 @default.
• W201323359 cites W2000162975 @default.
• W201323359 cites W2002831669 @default.
• W201323359 cites W2003008639 @default.
• W201323359 cites W2003648777 @default.
• W201323359 cites W2004247306 @default.
• W201323359 cites W2005126769 @default.
• W201323359 cites W2005935784 @default.
• W201323359 cites W2006649522 @default.
• W201323359 cites W2006773599 @default.
• W201323359 cites W2007275673 @default.
• W201323359 cites W2008450867 @default.
• W201323359 cites W2009435363 @default.
• W201323359 cites W2009441758 @default.
• W201323359 cites W2009749225 @default.
• W201323359 cites W2010971003 @default.
• W201323359 cites W2011378341 @default.
• W201323359 cites W2011647487 @default.
• W201323359 cites W2013617213 @default.
• W201323359 cites W2013927809 @default.
• W201323359 cites W2015112953 @default.
• W201323359 cites W2018544658 @default.
• W201323359 cites W2018779154 @default.
• W201323359 cites W2019054215 @default.
• W201323359 cites W2020099135 @default.
• W201323359 cites W2020168480 @default.
• W201323359 cites W2020828783 @default.
• W201323359 cites W2020929196 @default.
• W201323359 cites W2021112334 @default.
• W201323359 cites W2025826061 @default.
• W201323359 cites W2026610718 @default.
• W201323359 cites W2029806105 @default.
• W201323359 cites W2030065578 @default.
• W201323359 cites W2031481730 @default.
• W201323359 cites W2032344647 @default.
• W201323359 cites W2032455458 @default.
• W201323359 cites W2032477977 @default.
• W201323359 cites W2032731231 @default.
• W201323359 cites W2032789959 @default.
• W201323359 cites W2033462980 @default.
• W201323359 cites W2034795816 @default.
• W201323359 cites W2035500420 @default.
• W201323359 cites W2036152267 @default.
• W201323359 cites W2036357581 @default.
• W201323359 cites W2037078439 @default.
• W201323359 cites W2037217027 @default.

• next