FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013233737> ?p ?o ?g. }

• W2013233737 endingPage "2076" @default.
• W2013233737 startingPage "2071" @default.
• W2013233737 abstract "Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder characterized by extracellular accumulations of amyloid β (Aβ) peptides, intracellular accumulation of abnormal proteins, and early loss of basal forebrain neurons. Recent studies have indicated that the conformation of Aβ is crucial for neuronal toxicity, with intermediate misfolded forms such as oligomers being more toxic than the final fibrillar forms. Our previous work shows that Aβ blocks the potassium (K+) currents IM and IA in septal neurons, increasing firing rates, diminishing rhythmicity and firing coherence. Evidence also suggests that oxidative stress (OS) plays a role in AD pathogenesis. Thus we wished to determine the effect of oligomeric and fibrillar forms of Aβ1–42 on septohippocampal damage, oxidative damage, and dysfunction in AD. Oligomeric and fibrillar forms of Aβ1–42 were injected into the CA1 region of the hippocampus in live rats. The rats were sacrificed 24 hours and 1 month after Aβ or sham injection to additionally evaluate the temporal effects. The expression levels of the K+ voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2) and the OS-related genes superoxide dismutase 1, 8-oxoguanine DNA glycosylase, and monamine oxidase A, were analyzed in the hippocampus, medial, and lateral septum. Our results show that both forms of Aβ exhibit time-dependent differential modulation of OS and K+ channel genes in the analyzed regions. Importantly, we demonstrate that Aβ injected into the hippocampus triggered changes in gene expression in anatomical regions distant from the injection site. Thus the Aβ effect was transmitted to anatomically separate sites, because of the functional coupling of the brain structures." @default.
• W2013233737 created "2016-06-24" @default.
• W2013233737 creator A5027108951 @default.
• W2013233737 creator A5027749520 @default.
• W2013233737 creator A5027818184 @default.
• W2013233737 creator A5042044049 @default.
• W2013233737 creator A5042794299 @default.
• W2013233737 creator A5049797536 @default.
• W2013233737 creator A5056415798 @default.
• W2013233737 creator A5070239112 @default.
• W2013233737 creator A5075477128 @default.
• W2013233737 creator A5081164106 @default.
• W2013233737 date "2013-08-01" @default.
• W2013233737 modified "2023-10-14" @default.
• W2013233737 title "Amyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal system" @default.
• W2013233737 cites W1480524175 @default.
• W2013233737 cites W1976602187 @default.
• W2013233737 cites W1982724448 @default.
• W2013233737 cites W1986384924 @default.
• W2013233737 cites W1998149522 @default.
• W2013233737 cites W2003937841 @default.
• W2013233737 cites W2013118051 @default.
• W2013233737 cites W2017632516 @default.
• W2013233737 cites W2032004284 @default.
• W2013233737 cites W2032189765 @default.
• W2013233737 cites W2039706105 @default.
• W2013233737 cites W2041683774 @default.
• W2013233737 cites W2047240821 @default.
• W2013233737 cites W2048692719 @default.
• W2013233737 cites W2056994923 @default.
• W2013233737 cites W2057868451 @default.
• W2013233737 cites W2065375287 @default.
• W2013233737 cites W2066081053 @default.
• W2013233737 cites W2073589898 @default.
• W2013233737 cites W2085974525 @default.
• W2013233737 cites W2094485553 @default.
• W2013233737 cites W2095301528 @default.
• W2013233737 cites W2131633241 @default.
• W2013233737 cites W2135700152 @default.
• W2013233737 cites W2141013052 @default.
• W2013233737 cites W2141397725 @default.
• W2013233737 cites W2146173970 @default.
• W2013233737 cites W2171655572 @default.
• W2013233737 cites W2211252956 @default.
• W2013233737 doi "https://doi.org/10.1016/j.neurobiolaging.2013.02.005" @default.
• W2013233737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4890633" @default.
• W2013233737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23473707" @default.
• W2013233737 hasPublicationYear "2013" @default.
• W2013233737 type Work @default.
• W2013233737 sameAs 2013233737 @default.
• W2013233737 citedByCount "19" @default.
• W2013233737 countsByYear W20132337372014 @default.
• W2013233737 countsByYear W20132337372015 @default.
• W2013233737 countsByYear W20132337372016 @default.
• W2013233737 countsByYear W20132337372019 @default.
• W2013233737 countsByYear W20132337372020 @default.
• W2013233737 countsByYear W20132337372021 @default.
• W2013233737 countsByYear W20132337372022 @default.
• W2013233737 countsByYear W20132337372023 @default.
• W2013233737 crossrefType "journal-article" @default.
• W2013233737 hasAuthorship W2013233737A5027108951 @default.
• W2013233737 hasAuthorship W2013233737A5027749520 @default.
• W2013233737 hasAuthorship W2013233737A5027818184 @default.
• W2013233737 hasAuthorship W2013233737A5042044049 @default.
• W2013233737 hasAuthorship W2013233737A5042794299 @default.
• W2013233737 hasAuthorship W2013233737A5049797536 @default.
• W2013233737 hasAuthorship W2013233737A5056415798 @default.
• W2013233737 hasAuthorship W2013233737A5070239112 @default.
• W2013233737 hasAuthorship W2013233737A5075477128 @default.
• W2013233737 hasAuthorship W2013233737A5081164106 @default.
• W2013233737 hasBestOaLocation W20132337372 @default.
• W2013233737 hasConcept C126322002 @default.
• W2013233737 hasConcept C134018914 @default.
• W2013233737 hasConcept C169760540 @default.
• W2013233737 hasConcept C185592680 @default.
• W2013233737 hasConcept C25498285 @default.
• W2013233737 hasConcept C2775838275 @default.
• W2013233737 hasConcept C2776151105 @default.
• W2013233737 hasConcept C2781161787 @default.
• W2013233737 hasConcept C55493867 @default.
• W2013233737 hasConcept C71924100 @default.
• W2013233737 hasConcept C83743174 @default.
• W2013233737 hasConcept C86803240 @default.
• W2013233737 hasConcept C95444343 @default.
• W2013233737 hasConceptScore W2013233737C126322002 @default.
• W2013233737 hasConceptScore W2013233737C134018914 @default.
• W2013233737 hasConceptScore W2013233737C169760540 @default.
• W2013233737 hasConceptScore W2013233737C185592680 @default.
• W2013233737 hasConceptScore W2013233737C25498285 @default.
• W2013233737 hasConceptScore W2013233737C2775838275 @default.
• W2013233737 hasConceptScore W2013233737C2776151105 @default.
• W2013233737 hasConceptScore W2013233737C2781161787 @default.
• W2013233737 hasConceptScore W2013233737C55493867 @default.
• W2013233737 hasConceptScore W2013233737C71924100 @default.
• W2013233737 hasConceptScore W2013233737C83743174 @default.
• W2013233737 hasConceptScore W2013233737C86803240 @default.
• W2013233737 hasConceptScore W2013233737C95444343 @default.
• W2013233737 hasFunder F4320332161 @default.

• next