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- W2013242579 abstract "Letters15 April 1997Warfarin-Related Bleeding in the ElderlyStephan D. Fihn, MD, MPH, Mary B. McDonell, MS, and Jorja Henikoff, MSStephan D. Fihn, MD, MPHVeterans Affairs Puget Sound Health Care System, Seattle, WA 98108Search for more papers by this author, Mary B. McDonell, MSVeterans Affairs Puget Sound Health Care System, Seattle, WA 98108Search for more papers by this author, and Jorja Henikoff, MSVeterans Affairs Puget Sound Health Care System, Seattle, WA 98108Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-8-199704150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Fiore's comments but believe that he has misinterpreted our data and conclusions. Although he focuses on “an astonishingly high absolute annual risk” for life-threatening and fatal hemorrhage in patients 80 years of age and older, he seems to have overlooked our strong rejoinder that this result must be “interpreted with great caution” because the numbers of patients and events were relatively small. Even though our study sample was larger than those in almost all other published studies, the confidence limits around the risk estimate were wide, ranging from 1.3 to 15.6. Excessive concern for this ...References1. Fihn SD, McDonell M, Martin D, Henikoff J, Vermes D, Kent D, et al. Risk factors for complications of chronic anticoagulation. A multicenter study. The Warfarin Optimized Outpatient Follow-up Study Group. Ann Intern Med. 1993; 118:511-20. Google Scholar2. Kent DL, Vermes D, McDonell M, Henikoff J, Fihn SD. A model for planning optimal follow-up for outpatients on warfarin anticoagulation. Med Decis Making. 1992; 12:132-41. Google Scholar3. Fihn SD, McDonell MB, Vermes D, Henikoff JG, Martin D, Kent DL. Optimal scheduling of patients on warfarin using a stochastic model: a multicenter randomized trial. J Gen Intern Med. 1994; 9:131-9. Google Scholar4. White RH, McKittrick T, Takakuwa J, Callahan CM, McDonnell MA, Fihn SD. Management and prognosis of life-threatening bleeding during warfarin therapy. Arch Intern Med. 1996; 156:1197-201. Google Scholar5. Lancaster TR, Singer DE, Sheehan MA, Oertel LB, Maraventano SW, Hughes RA, et al. The impact of long-term warfarin therapy on quality of life. Evidence from a randomized trial. Arch Intern Med. 1991; 151:1944-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAnticoagulation orale en pratique gériatrique 15 April 1997Volume 126, Issue 8Page: 660-661KeywordsConfidence limitElderlyHemorrhageProspective studies Issue Published: 15 April 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ..." @default.
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- W2013242579 title "Warfarin-Related Bleeding in the Elderly" @default.
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