FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W20132494> ?p ?o ?g. }

• W20132494 endingPage "430" @default.
• W20132494 startingPage "413" @default.
• W20132494 abstract "Recent studies on the formation and molecular organization of the mammalian heart have emphasized the architectural and functional importance of the adhering junctions (AJs), which are densely clustered in the bipolar end regions (intercalated disks, IDs) connecting the elongated cardiomyocytes of the adult heart. Moreover, we learned from genetic studies of mutated AJ proteins that desmosomal proteins, which for the most part are integral components of ID-specific composite AJs (areae compositae, AC), are essential in heart development and function. Developmental studies have shown that the bipolar concentration of cardiomyocyte AJs in IDs is a rather late process and only completed postnatally. Here we report that in the adult hearts of diverse lower vertebrates (fishes, amphibia, birds) most AJs remain separate and distinct in molecular character, representing either fasciae adhaerentes, maculae adhaerentes (desmosomes) or – less frequently – some form of AC. In the mature hearts of the amphibian and fish species examined a large proportion of the AJs connecting cardiomyocytes is not clustered in the IDs but remains located on the lateral surfaces where they appear either as puncta adhaerentia or as desmosomes. In many places, these puncta connect parallel cardiomyocytes in spectacular ladder-like regular arrays (scalae adhaerentes) correlated with – and connected by – electron-dense plaque-like material to sarcomeric Z-bands. In the avian hearts, on the other hand, most AJs are clustered in the IDs but only a small proportion of the desmosomes appears as AC, compared to the dominance of distinct fasciae adhaerentes. We conclude that the fusion and amalgamation of AJs and desmosomes to ACs is a late process both in ontogenesis and in evolution. The significance and possible functional implications of the specific junctional structures in vertebrate evolution and the class-specific requirements of architectural and molecular assembly adaptation during regeneration processes are discussed." @default.
• W20132494 created "2016-06-24" @default.
• W20132494 creator A5052267229 @default.
• W20132494 creator A5084268334 @default.
• W20132494 date "2008-07-01" @default.
• W20132494 modified "2023-10-11" @default.
• W20132494 title "The area composita of adhering junctions connecting heart muscle cells of vertebrates." @default.
• W20132494 cites W1173227692 @default.
• W20132494 cites W1544975035 @default.
• W20132494 cites W177060896 @default.
• W20132494 cites W1776006349 @default.
• W20132494 cites W1917492683 @default.
• W20132494 cites W1963655560 @default.
• W20132494 cites W1964045664 @default.
• W20132494 cites W1964965105 @default.
• W20132494 cites W1967281362 @default.
• W20132494 cites W1969145239 @default.
• W20132494 cites W1972701743 @default.
• W20132494 cites W1973578915 @default.
• W20132494 cites W1973592555 @default.
• W20132494 cites W1973706332 @default.
• W20132494 cites W1974052160 @default.
• W20132494 cites W1975355340 @default.
• W20132494 cites W1977007311 @default.
• W20132494 cites W1978084278 @default.
• W20132494 cites W1978898180 @default.
• W20132494 cites W1982213890 @default.
• W20132494 cites W1982726291 @default.
• W20132494 cites W1986236472 @default.
• W20132494 cites W1987071096 @default.
• W20132494 cites W1990349390 @default.
• W20132494 cites W1993616331 @default.
• W20132494 cites W1999776252 @default.
• W20132494 cites W2003828198 @default.
• W20132494 cites W2005073317 @default.
• W20132494 cites W2009883870 @default.
• W20132494 cites W2016716219 @default.
• W20132494 cites W2018468114 @default.
• W20132494 cites W2019651899 @default.
• W20132494 cites W2020550499 @default.
• W20132494 cites W2023958353 @default.
• W20132494 cites W2025512784 @default.
• W20132494 cites W2030618223 @default.
• W20132494 cites W2034544118 @default.
• W20132494 cites W2038181873 @default.
• W20132494 cites W2042297292 @default.
• W20132494 cites W2047926713 @default.
• W20132494 cites W2048410503 @default.
• W20132494 cites W2052483379 @default.
• W20132494 cites W2053130001 @default.
• W20132494 cites W2054286277 @default.
• W20132494 cites W2056689671 @default.
• W20132494 cites W2057416981 @default.
• W20132494 cites W2057853736 @default.
• W20132494 cites W2058099844 @default.
• W20132494 cites W2061977587 @default.
• W20132494 cites W2063274248 @default.
• W20132494 cites W2063528311 @default.
• W20132494 cites W2063925852 @default.
• W20132494 cites W2063964442 @default.
• W20132494 cites W2069887070 @default.
• W20132494 cites W2073420780 @default.
• W20132494 cites W2075176977 @default.
• W20132494 cites W2075325773 @default.
• W20132494 cites W2076807452 @default.
• W20132494 cites W2078443370 @default.
• W20132494 cites W2083887563 @default.
• W20132494 cites W2085218980 @default.
• W20132494 cites W2086803843 @default.
• W20132494 cites W2091013332 @default.
• W20132494 cites W2092922521 @default.
• W20132494 cites W2094647249 @default.
• W20132494 cites W2095841223 @default.
• W20132494 cites W2096650620 @default.
• W20132494 cites W2099117877 @default.
• W20132494 cites W2103618365 @default.
• W20132494 cites W2107575131 @default.
• W20132494 cites W2108427723 @default.
• W20132494 cites W2110168421 @default.
• W20132494 cites W2113172950 @default.
• W20132494 cites W2114474037 @default.
• W20132494 cites W2121038707 @default.
• W20132494 cites W2121254490 @default.
• W20132494 cites W2126747203 @default.
• W20132494 cites W2130334101 @default.
• W20132494 cites W2140452645 @default.
• W20132494 cites W2141279088 @default.
• W20132494 cites W2141873651 @default.
• W20132494 cites W2143298643 @default.
• W20132494 cites W2143395921 @default.
• W20132494 cites W2156024234 @default.
• W20132494 cites W2157479429 @default.
• W20132494 cites W2159360972 @default.
• W20132494 cites W2161404626 @default.
• W20132494 cites W2166191977 @default.
• W20132494 cites W2169054659 @default.
• W20132494 cites W2185613772 @default.
• W20132494 cites W2242263946 @default.

• next