Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013253709> ?p ?o ?g. }
- W2013253709 endingPage "569" @default.
- W2013253709 startingPage "563" @default.
- W2013253709 abstract "Multidrug and toxin extrusion (MATE) 1 and MATE2-K, H+/organic cation antiporters, are located at the brush-border membrane of renal proximal tubules. The present study aimed to clarify the role of MATE transporters in tubular secretion of varenicline. Varenicline at a dose of 5 mg/kg was administered to wild-type and Matel-knockout mice via the jugular vein, and its uptake was measured by high- performance liquid chromatography. The renal secretory clearance of and systemic exposure to varenicline were significantly decreased (54.6%, p < 0.05) and increased (116%, p < 0.05) respectively, by the genetic disruption of Matel in mice. Uptake of varenicline and [14C]tetraethylammonium (TEA) was examined in HEK293 cells transiently expressing the human (h) MATE1, hMATE2-K, mouse (m) MATE1, and hOCT2 basolateral organic cation transporter. [14C]TEA uptake in HEK293 cells expressing MATE transporters and hOCT2 was decreased in the presence of varenicline. The calculated IC50 values for hMATE1, hMATE2-K, mMATE1, and hOCT2 were 62.2 ± 6.5, 122.3 ± 67.6, 255.0 ± 37.9, and 1,003.9 ± 135.8 (pM; mean ± S.E. for three separate experiments), respectively. Varenicline uptake was significantly increased in HEK293 cells expressing mMATE1, hMATE1, or hMATE2-K cDNA as well as hOCT2 compared to empty vector-transfected cells. In conclusion, renal MATE transporters were found to be responsible for renal tubular secretion of varenicline." @default.
- W2013253709 created "2016-06-24" @default.
- W2013253709 creator A5000863624 @default.
- W2013253709 creator A5004410085 @default.
- W2013253709 creator A5008302696 @default.
- W2013253709 creator A5010169211 @default.
- W2013253709 creator A5033753156 @default.
- W2013253709 creator A5042541903 @default.
- W2013253709 date "2012-01-01" @default.
- W2013253709 modified "2023-10-14" @default.
- W2013253709 title "Renal Tubular Secretion of Varenicline by Multidrug and Toxin Extrusion (MATE) Transporters" @default.
- W2013253709 cites W1573828630 @default.
- W2013253709 cites W1970931038 @default.
- W2013253709 cites W1977469555 @default.
- W2013253709 cites W1986282494 @default.
- W2013253709 cites W1989580478 @default.
- W2013253709 cites W1995408306 @default.
- W2013253709 cites W2003894158 @default.
- W2013253709 cites W2025894603 @default.
- W2013253709 cites W2028767159 @default.
- W2013253709 cites W2030419995 @default.
- W2013253709 cites W2034886511 @default.
- W2013253709 cites W2047944613 @default.
- W2013253709 cites W2057721101 @default.
- W2013253709 cites W2071313065 @default.
- W2013253709 cites W2073650307 @default.
- W2013253709 cites W2090414853 @default.
- W2013253709 cites W2094835493 @default.
- W2013253709 cites W2097279274 @default.
- W2013253709 cites W2099823373 @default.
- W2013253709 cites W2100282012 @default.
- W2013253709 cites W2101456362 @default.
- W2013253709 cites W2110289717 @default.
- W2013253709 cites W2112623713 @default.
- W2013253709 cites W2116765178 @default.
- W2013253709 cites W2120740366 @default.
- W2013253709 cites W2128358586 @default.
- W2013253709 cites W2131229783 @default.
- W2013253709 cites W2142042669 @default.
- W2013253709 cites W2142286560 @default.
- W2013253709 cites W2157190376 @default.
- W2013253709 cites W2157607469 @default.
- W2013253709 cites W2158916292 @default.
- W2013253709 cites W2163574850 @default.
- W2013253709 cites W2172232346 @default.
- W2013253709 cites W2341393614 @default.
- W2013253709 doi "https://doi.org/10.2133/dmpk.dmpk-11-rg-156" @default.
- W2013253709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22510868" @default.
- W2013253709 hasPublicationYear "2012" @default.
- W2013253709 type Work @default.
- W2013253709 sameAs 2013253709 @default.
- W2013253709 citedByCount "15" @default.
- W2013253709 countsByYear W20132537092013 @default.
- W2013253709 countsByYear W20132537092014 @default.
- W2013253709 countsByYear W20132537092015 @default.
- W2013253709 countsByYear W20132537092016 @default.
- W2013253709 countsByYear W20132537092017 @default.
- W2013253709 countsByYear W20132537092018 @default.
- W2013253709 countsByYear W20132537092019 @default.
- W2013253709 crossrefType "journal-article" @default.
- W2013253709 hasAuthorship W2013253709A5000863624 @default.
- W2013253709 hasAuthorship W2013253709A5004410085 @default.
- W2013253709 hasAuthorship W2013253709A5008302696 @default.
- W2013253709 hasAuthorship W2013253709A5010169211 @default.
- W2013253709 hasAuthorship W2013253709A5033753156 @default.
- W2013253709 hasAuthorship W2013253709A5042541903 @default.
- W2013253709 hasConcept C104317684 @default.
- W2013253709 hasConcept C126322002 @default.
- W2013253709 hasConcept C134018914 @default.
- W2013253709 hasConcept C149011108 @default.
- W2013253709 hasConcept C161457703 @default.
- W2013253709 hasConcept C170493617 @default.
- W2013253709 hasConcept C174510640 @default.
- W2013253709 hasConcept C185592680 @default.
- W2013253709 hasConcept C2777053506 @default.
- W2013253709 hasConcept C2779547902 @default.
- W2013253709 hasConcept C2780091579 @default.
- W2013253709 hasConcept C49039625 @default.
- W2013253709 hasConcept C55493867 @default.
- W2013253709 hasConcept C71924100 @default.
- W2013253709 hasConcept C86803240 @default.
- W2013253709 hasConcept C98274493 @default.
- W2013253709 hasConceptScore W2013253709C104317684 @default.
- W2013253709 hasConceptScore W2013253709C126322002 @default.
- W2013253709 hasConceptScore W2013253709C134018914 @default.
- W2013253709 hasConceptScore W2013253709C149011108 @default.
- W2013253709 hasConceptScore W2013253709C161457703 @default.
- W2013253709 hasConceptScore W2013253709C170493617 @default.
- W2013253709 hasConceptScore W2013253709C174510640 @default.
- W2013253709 hasConceptScore W2013253709C185592680 @default.
- W2013253709 hasConceptScore W2013253709C2777053506 @default.
- W2013253709 hasConceptScore W2013253709C2779547902 @default.
- W2013253709 hasConceptScore W2013253709C2780091579 @default.
- W2013253709 hasConceptScore W2013253709C49039625 @default.
- W2013253709 hasConceptScore W2013253709C55493867 @default.
- W2013253709 hasConceptScore W2013253709C71924100 @default.
- W2013253709 hasConceptScore W2013253709C86803240 @default.
- W2013253709 hasConceptScore W2013253709C98274493 @default.