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- W2013256429 abstract "Substitution of choline or sucrose for Na+ in the medium surrounding frog spinal ganglia causes an inhibition of fast axonal transport in vitro. Since an increased Ca2+ influx into neurons does occur in these media, the present experiments examined the possibility that the effect on transport is mediated by an increase in intracellular free Ca2+. The combination of the choline substitution with a 3-fold increase in extracellular Ca2+ reduced transport of [3H]proteins to 75% of control (as compared to the 63% obtained previously with choline alone), thus providing no evidence of an enhancement of choline's effect by a second factor which promotes an increase in intracellular Ca2+. When Li+ was substituted for Na+, the quantity of [3H]proteins transported fell to 40% of control despite the fact that the Li+ substitution does not modify Ca2+ fluxes across the plasma membrane in neurons of the frog spinal nerve. The present findings suggest that removal of Na+ interferes with fast axonal transport by a mechanism other than an increase in intracellular Ca2+." @default.
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- W2013256429 date "1981-12-01" @default.
- W2013256429 modified "2023-10-16" @default.
- W2013256429 title "On the mechanism of the inhibition of fast axonal transport caused by exposure of frog spinal ganglia to a sodium-deficient medium" @default.
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- W2013256429 doi "https://doi.org/10.1016/0304-3940(81)90256-1" @default.
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