FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013257515> ?p ?o ?g. }

• W2013257515 endingPage "e35641" @default.
• W2013257515 startingPage "e35641" @default.
• W2013257515 abstract "Background For insects the sense of smell and associated olfactory-driven behaviours are essential for survival. Insects detect odorants with families of olfactory receptor proteins that are very different to those of mammals, and there are likely to be other unique genes and genetic pathways involved in the function and development of the insect olfactory system. Methodology/Principal Findings We have performed a genetic screen of a set of 505 Drosophila melanogaster gene trap insertion lines to identify novel genes expressed in the adult olfactory organs. We identified 16 lines with expression in the olfactory organs, many of which exhibited expression of the trapped genes in olfactory receptor neurons. Phenotypic analysis showed that six of the lines have decreased olfactory responses in a behavioural assay, and for one of these we showed that precise excision of the P element reverts the phenotype to wild type, confirming a role for the trapped gene in olfaction. To confirm the identity of the genes trapped in the lines we performed molecular analysis of some of the insertion sites. While for many lines the reported insertion sites were correct, we also demonstrated that for a number of lines the reported location of the element was incorrect, and in three lines there were in fact two pGT element insertions. Conclusions/Significance We identified 16 new genes expressed in the Drosophila olfactory organs, the majority in neurons, and for several of the gene trap lines demonstrated a defect in olfactory-driven behaviour. Further characterisation of these genes and their roles in olfactory system function and development will increase our understanding of how the insect olfactory system has evolved to perform the same essential function to that of mammals, but using very different molecular genetic mechanisms." @default.
• W2013257515 created "2016-06-24" @default.
• W2013257515 creator A5008808643 @default.
• W2013257515 creator A5070859919 @default.
• W2013257515 creator A5086428392 @default.
• W2013257515 creator A5086965686 @default.
• W2013257515 date "2012-04-18" @default.
• W2013257515 modified "2023-10-18" @default.
• W2013257515 title "A Screen for Genes Expressed in the Olfactory Organs of Drosophila melanogaster Identifies Genes Involved in Olfactory Behaviour" @default.
• W2013257515 cites W1923182349 @default.
• W2013257515 cites W1967853853 @default.
• W2013257515 cites W1970078484 @default.
• W2013257515 cites W1972201383 @default.
• W2013257515 cites W1972939099 @default.
• W2013257515 cites W1982124226 @default.
• W2013257515 cites W1996323440 @default.
• W2013257515 cites W1996674462 @default.
• W2013257515 cites W2004026630 @default.
• W2013257515 cites W2005111341 @default.
• W2013257515 cites W2006229889 @default.
• W2013257515 cites W2009038548 @default.
• W2013257515 cites W2011685750 @default.
• W2013257515 cites W2022090845 @default.
• W2013257515 cites W2041835458 @default.
• W2013257515 cites W2049422371 @default.
• W2013257515 cites W2051867914 @default.
• W2013257515 cites W2061961323 @default.
• W2013257515 cites W2075925574 @default.
• W2013257515 cites W2078997561 @default.
• W2013257515 cites W2082350440 @default.
• W2013257515 cites W2082788644 @default.
• W2013257515 cites W2084929485 @default.
• W2013257515 cites W2088196417 @default.
• W2013257515 cites W2091183380 @default.
• W2013257515 cites W2100270425 @default.
• W2013257515 cites W2110618077 @default.
• W2013257515 cites W2114249790 @default.
• W2013257515 cites W2122352376 @default.
• W2013257515 cites W2127697722 @default.
• W2013257515 cites W2144131842 @default.
• W2013257515 cites W2152234914 @default.
• W2013257515 cites W2153340798 @default.
• W2013257515 cites W2158299320 @default.
• W2013257515 cites W2160309557 @default.
• W2013257515 cites W2164339920 @default.
• W2013257515 doi "https://doi.org/10.1371/journal.pone.0035641" @default.
• W2013257515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3329464" @default.
• W2013257515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22530061" @default.
• W2013257515 hasPublicationYear "2012" @default.
• W2013257515 type Work @default.
• W2013257515 sameAs 2013257515 @default.
• W2013257515 citedByCount "19" @default.
• W2013257515 countsByYear W20132575152014 @default.
• W2013257515 countsByYear W20132575152015 @default.
• W2013257515 countsByYear W20132575152016 @default.
• W2013257515 countsByYear W20132575152017 @default.
• W2013257515 countsByYear W20132575152018 @default.
• W2013257515 countsByYear W20132575152019 @default.
• W2013257515 countsByYear W20132575152020 @default.
• W2013257515 countsByYear W20132575152021 @default.
• W2013257515 countsByYear W20132575152022 @default.
• W2013257515 countsByYear W20132575152023 @default.
• W2013257515 crossrefType "journal-article" @default.
• W2013257515 hasAuthorship W2013257515A5008808643 @default.
• W2013257515 hasAuthorship W2013257515A5070859919 @default.
• W2013257515 hasAuthorship W2013257515A5086428392 @default.
• W2013257515 hasAuthorship W2013257515A5086965686 @default.
• W2013257515 hasBestOaLocation W20132575151 @default.
• W2013257515 hasConcept C104317684 @default.
• W2013257515 hasConcept C127716648 @default.
• W2013257515 hasConcept C163214680 @default.
• W2013257515 hasConcept C169760540 @default.
• W2013257515 hasConcept C201792869 @default.
• W2013257515 hasConcept C207177822 @default.
• W2013257515 hasConcept C2779404012 @default.
• W2013257515 hasConcept C2779980732 @default.
• W2013257515 hasConcept C2780104201 @default.
• W2013257515 hasConcept C54355233 @default.
• W2013257515 hasConcept C86803240 @default.
• W2013257515 hasConcept C95444343 @default.
• W2013257515 hasConceptScore W2013257515C104317684 @default.
• W2013257515 hasConceptScore W2013257515C127716648 @default.
• W2013257515 hasConceptScore W2013257515C163214680 @default.
• W2013257515 hasConceptScore W2013257515C169760540 @default.
• W2013257515 hasConceptScore W2013257515C201792869 @default.
• W2013257515 hasConceptScore W2013257515C207177822 @default.
• W2013257515 hasConceptScore W2013257515C2779404012 @default.
• W2013257515 hasConceptScore W2013257515C2779980732 @default.
• W2013257515 hasConceptScore W2013257515C2780104201 @default.
• W2013257515 hasConceptScore W2013257515C54355233 @default.
• W2013257515 hasConceptScore W2013257515C86803240 @default.
• W2013257515 hasConceptScore W2013257515C95444343 @default.
• W2013257515 hasIssue "4" @default.
• W2013257515 hasLocation W20132575151 @default.
• W2013257515 hasLocation W20132575152 @default.
• W2013257515 hasLocation W20132575153 @default.
• W2013257515 hasLocation W20132575154 @default.
• W2013257515 hasLocation W20132575155 @default.

• next