FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013260094> ?p ?o ?g. }

• W2013260094 endingPage "1352" @default.
• W2013260094 startingPage "1345" @default.
• W2013260094 abstract "The focus of this investigation was to examine the potential beneficial effects of the selective thromboxane synthetase inhibitor CGS 13080 (imidazo [1,5-a] pyridine-5-hexanoic acid) on coronary blood flow after streptokinase-induced thrombolysis. Thrombotic occlusion of the circumflex coronary artery was produced by electrolytic (100 μA anodal current) injury to the intimal surface of the circumflex coronary artery at the site of a noncircumferential stenosis in dogs anesthetized with pentobarbital to have open-chest surgery. Intracoronary streptokinase, 6000 IU/kg in 3 ml saline solution, was infused at 0.05 ml/min for 1 hour, beginning 30 minutes after the formation of an occlusive thrombus. The animals were assigned randomly to two groups. In group I (n = 10) the intravenous infusion of vehicle was begun simultaneously with the intracoronary administration of streptokinase and continued for 2 hours after thrombolysis had been achieved. The animals in group II (n = 10) received intravenous CGS 13080 (1 mg/kg/hr) along with intracoronary streptokinase. Infarct size was assessed by a dual perfusion technique with Evans blue and triphenyltetrazolium stains to demarcate the normally perfused myocardium from the area at risk and the infarct zone within the risk region. The two groups did not differ with respect to baseline coronary blood flow, time to the development of coronary artery thrombotic occlusion, or time to achieve thrombolysis. Oscillations in coronary blood flow were more frequent in group I than in group II (group I, 9 ± 2.2; group II, 4.4 ± 0.8 oscillation/min × 100, p < 0.05 [mean ± SEM]). Reocclusion was observed more frequently in group I than in group II (8 of 10 [80%] vs 2 of 10 [20%], p < 0.05). Infarct size expressed as a percent of the total left ventricular mass was similar ([IZLV] group I, 5% ± 2%; group II, 4% ± 1%), as was the percent of the left ventricle dependent on the blood flow distribution from the left circumflex coronary artery or the area at risk of infarction ([ARLV] 37% ± 2% vs 40% ± 3%, respectively). These results demonstrate that the thromboxane synthetase inhibitor CGS 13080, in combination with the thrombolytic agent streptokinase, is able to maintain patency of the injured coronary artery after thrombolysis and to decrease the frequency of oscillatory flow responses. The results suggest a possible role for thromboxane as a contributor to the process of thrombotic reocclusion after successful thrombolysis." @default.
• W2013260094 created "2016-06-24" @default.
• W2013260094 creator A5004072092 @default.
• W2013260094 creator A5010120954 @default.
• W2013260094 creator A5078585629 @default.
• W2013260094 creator A5083273963 @default.
• W2013260094 date "1987-06-01" @default.
• W2013260094 modified "2023-10-18" @default.
• W2013260094 title "Thromboxane synthetase inhibition with CGS 13080 improves coronary blood flow after streptokinase-induced thrombolysis" @default.
• W2013260094 cites W14052009 @default.
• W2013260094 cites W1607743415 @default.
• W2013260094 cites W1973311463 @default.
• W2013260094 cites W1981159906 @default.
• W2013260094 cites W1991117742 @default.
• W2013260094 cites W1994336882 @default.
• W2013260094 cites W2007379138 @default.
• W2013260094 cites W2014791861 @default.
• W2013260094 cites W2046646134 @default.
• W2013260094 cites W2050175937 @default.
• W2013260094 cites W2051153718 @default.
• W2013260094 cites W2073574950 @default.
• W2013260094 cites W2075887610 @default.
• W2013260094 cites W2078249773 @default.
• W2013260094 cites W2078705015 @default.
• W2013260094 cites W2078745461 @default.
• W2013260094 cites W2092823124 @default.
• W2013260094 cites W2118145139 @default.
• W2013260094 cites W2119518368 @default.
• W2013260094 cites W2411627375 @default.
• W2013260094 cites W4250604363 @default.
• W2013260094 doi "https://doi.org/10.1016/0002-8703(87)90646-6" @default.
• W2013260094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3591602" @default.
• W2013260094 hasPublicationYear "1987" @default.
• W2013260094 type Work @default.
• W2013260094 sameAs 2013260094 @default.
• W2013260094 citedByCount "39" @default.
• W2013260094 crossrefType "journal-article" @default.
• W2013260094 hasAuthorship W2013260094A5004072092 @default.
• W2013260094 hasAuthorship W2013260094A5010120954 @default.
• W2013260094 hasAuthorship W2013260094A5078585629 @default.
• W2013260094 hasAuthorship W2013260094A5083273963 @default.
• W2013260094 hasBestOaLocation W20132600942 @default.
• W2013260094 hasConcept C126322002 @default.
• W2013260094 hasConcept C158846371 @default.
• W2013260094 hasConcept C164705383 @default.
• W2013260094 hasConcept C2776336681 @default.
• W2013260094 hasConcept C2776820930 @default.
• W2013260094 hasConcept C2777397205 @default.
• W2013260094 hasConcept C2779581417 @default.
• W2013260094 hasConcept C2780393670 @default.
• W2013260094 hasConcept C2781362458 @default.
• W2013260094 hasConcept C42219234 @default.
• W2013260094 hasConcept C500558357 @default.
• W2013260094 hasConcept C71924100 @default.
• W2013260094 hasConceptScore W2013260094C126322002 @default.
• W2013260094 hasConceptScore W2013260094C158846371 @default.
• W2013260094 hasConceptScore W2013260094C164705383 @default.
• W2013260094 hasConceptScore W2013260094C2776336681 @default.
• W2013260094 hasConceptScore W2013260094C2776820930 @default.
• W2013260094 hasConceptScore W2013260094C2777397205 @default.
• W2013260094 hasConceptScore W2013260094C2779581417 @default.
• W2013260094 hasConceptScore W2013260094C2780393670 @default.
• W2013260094 hasConceptScore W2013260094C2781362458 @default.
• W2013260094 hasConceptScore W2013260094C42219234 @default.
• W2013260094 hasConceptScore W2013260094C500558357 @default.
• W2013260094 hasConceptScore W2013260094C71924100 @default.
• W2013260094 hasIssue "6" @default.
• W2013260094 hasLocation W20132600941 @default.
• W2013260094 hasLocation W20132600942 @default.
• W2013260094 hasLocation W20132600943 @default.
• W2013260094 hasOpenAccess W2013260094 @default.
• W2013260094 hasPrimaryLocation W20132600941 @default.
• W2013260094 hasRelatedWork W2048099422 @default.
• W2013260094 hasRelatedWork W2073642433 @default.
• W2013260094 hasRelatedWork W2087532281 @default.
• W2013260094 hasRelatedWork W2361294709 @default.
• W2013260094 hasRelatedWork W2398651995 @default.
• W2013260094 hasRelatedWork W2408776976 @default.
• W2013260094 hasRelatedWork W2409567174 @default.
• W2013260094 hasRelatedWork W2551681864 @default.
• W2013260094 hasRelatedWork W3110025068 @default.
• W2013260094 hasRelatedWork W4280531292 @default.
• W2013260094 hasVolume "113" @default.
• W2013260094 isParatext "false" @default.
• W2013260094 isRetracted "false" @default.
• W2013260094 magId "2013260094" @default.
• W2013260094 workType "article" @default.