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- W2013263553 abstract "Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4 + CD25 + regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3 + Treg cells in the control of destructive<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3 + Treg cells." @default.
- W2013263553 created "2016-06-24" @default.
- W2013263553 creator A5009116767 @default.
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- W2013263553 creator A5062073102 @default.
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- W2013263553 creator A5064824295 @default.
- W2013263553 date "2013-01-01" @default.
- W2013263553 modified "2023-10-16" @default.
- W2013263553 title "Foxp3<sup>+</sup>Regulatory T Cells in Mouse Models of Type 1 Diabetes" @default.
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- W2013263553 doi "https://doi.org/10.1155/2013/940710" @default.
- W2013263553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3647588" @default.
- W2013263553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23691523" @default.
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