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• W2013269746 abstract "SUMMARY Anaesthetics influence cardiac electrical activity by various mechanisms; thus, they may have pro‐arrhythmic or anti‐arrhythmic actions. Increased P‐wave dispersion is associated with a risk of paroxysmal atrial fibrillation. The aim of the present study was to analyse the impact of propofol and desflurane on changes in P wave dispersion, which may reflect the anti‐arrhythmic effects of these drugs. Fifty patients undergoing scheduled surgery were included in the study. Patients were divided into two equal groups: a propofol group and a desflurane group. Patients in the propofol group were initially administered 2.5 mg/kg propofol, followed by infusion of 6 mg/kg per h propofol. Anaesthesia in the desflurane group was achieved using inhalation induction, with concentrations up to 8–12.5 vol%. When signs of adequate anaesthesia were observed, the concentration of desflurane was reduced to 6 vol%. An electrocardiogram (ECG) was obtained before induction and then again 1, 3 and 5 min after the initiation of propofol infusion or the induction of anaesthesia in the desflurane group; additional measurements were performed after tracheal intubation. P‐wave dispersion was assessed by differences in maximal and minimal P‐wave duration on a 12‐lead ECG. P‐wave dispersion did not change over time in the desflurane group. In the propofol group, there was a significant decrease in P‐wave dispersion after 3 and 5 min of anaesthesia. Significant differences were observed between study groups after 1, 3 and 5 min of anaesthesia, and disappeared after tracheal intubation. Mean and maximal P‐wave duration did not change in either group. In conlcusion, propofol decreases P‐wave dispersion and this seems to be connected with the anti‐arrhythmic properties of the drug." @default.
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• W2013269746 date "2008-08-01" @default.
• W2013269746 modified "2023-10-16" @default.
• W2013269746 title "EFFECT OF ANAESTHETIC AGENTS ON P-WAVE DISPERSION ON THE ELECTROCARDIOGRAM: COMPARISON OF PROPOFOL AND DESFLURANE" @default.
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• W2013269746 doi "https://doi.org/10.1111/j.1440-1681.2008.04963.x" @default.
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