Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013279239> ?p ?o ?g. }
- W2013279239 endingPage "1579" @default.
- W2013279239 startingPage "1567" @default.
- W2013279239 abstract "Curcumin arrests the proliferation of acute promyelocytic leukemia (APL) cells by stabilizing the misfolded nuclear receptor co-repressor (N-CoR) protein, thereby sensitizing APL cells to apoptosis induced by the unfolded protein response. This phenomenon was attributed to inhibition of the proteasomal and protease-induced breakdown of misfolded N-CoR by curcumin. Curcumin is, however, a modest inhibitor and affected the viability of APL cells at micromolar concentrations. Modifying curcumin at its conjugated β-diketone linker and terminal phenyl rings yielded potent congeners with sub-micromolar growth inhibitory activities which selectively kill APL cells over non-APL leukemic and nonmalignant cells. Analogues with pronounced APL-selective anti-proliferative activities, as observed in representative dibenzylidenecyclohexanones and dibenzylidenecyclopentanones, strongly promoted the accumulation of misfolded and nonfunctional N-CoR at significantly lower concentrations than their growth inhibitory IC50 values. These compounds also inhibited the human 20S proteasome in an enzyme-based assay, thus providing convincing support for the prevailing hypothesis that impeding the degradation of N-CoR is a key mechanistic event contributing to APL cell death." @default.
- W2013279239 created "2016-06-24" @default.
- W2013279239 creator A5020791920 @default.
- W2013279239 creator A5026989749 @default.
- W2013279239 creator A5029259484 @default.
- W2013279239 creator A5060781921 @default.
- W2013279239 creator A5062498717 @default.
- W2013279239 date "2012-08-06" @default.
- W2013279239 modified "2023-09-25" @default.
- W2013279239 title "Curcumin Analogues with Potent and Selective Anti-proliferative Activity on Acute Promyelocytic Leukemia: Involvement of Accumulated Misfolded Nuclear Receptor Co-repressor (N-CoR) Protein as a Basis for Selective Activity" @default.
- W2013279239 cites W110788161 @default.
- W2013279239 cites W1486948598 @default.
- W2013279239 cites W1550565578 @default.
- W2013279239 cites W1589900156 @default.
- W2013279239 cites W1965388358 @default.
- W2013279239 cites W1972179974 @default.
- W2013279239 cites W1975337436 @default.
- W2013279239 cites W1976194786 @default.
- W2013279239 cites W1991327193 @default.
- W2013279239 cites W2004827880 @default.
- W2013279239 cites W2005496228 @default.
- W2013279239 cites W2009897558 @default.
- W2013279239 cites W2012253608 @default.
- W2013279239 cites W2026441085 @default.
- W2013279239 cites W2030215148 @default.
- W2013279239 cites W2031909042 @default.
- W2013279239 cites W2033447671 @default.
- W2013279239 cites W2040251321 @default.
- W2013279239 cites W2043514699 @default.
- W2013279239 cites W2043632706 @default.
- W2013279239 cites W2052593879 @default.
- W2013279239 cites W2061194648 @default.
- W2013279239 cites W2063083122 @default.
- W2013279239 cites W2069532898 @default.
- W2013279239 cites W2070973948 @default.
- W2013279239 cites W2074858197 @default.
- W2013279239 cites W2077365696 @default.
- W2013279239 cites W2087067683 @default.
- W2013279239 cites W2087481253 @default.
- W2013279239 cites W2087854103 @default.
- W2013279239 cites W2091378741 @default.
- W2013279239 cites W2095624924 @default.
- W2013279239 cites W2096102731 @default.
- W2013279239 cites W2104788426 @default.
- W2013279239 cites W2136879986 @default.
- W2013279239 cites W2144284827 @default.
- W2013279239 cites W2145887093 @default.
- W2013279239 cites W2153680238 @default.
- W2013279239 cites W2155602001 @default.
- W2013279239 cites W2166218646 @default.
- W2013279239 doi "https://doi.org/10.1002/cmdc.201200293" @default.
- W2013279239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22887959" @default.
- W2013279239 hasPublicationYear "2012" @default.
- W2013279239 type Work @default.
- W2013279239 sameAs 2013279239 @default.
- W2013279239 citedByCount "21" @default.
- W2013279239 countsByYear W20132792392013 @default.
- W2013279239 countsByYear W20132792392014 @default.
- W2013279239 countsByYear W20132792392015 @default.
- W2013279239 countsByYear W20132792392016 @default.
- W2013279239 countsByYear W20132792392017 @default.
- W2013279239 countsByYear W20132792392018 @default.
- W2013279239 countsByYear W20132792392019 @default.
- W2013279239 countsByYear W20132792392020 @default.
- W2013279239 countsByYear W20132792392022 @default.
- W2013279239 countsByYear W20132792392023 @default.
- W2013279239 crossrefType "journal-article" @default.
- W2013279239 hasAuthorship W2013279239A5020791920 @default.
- W2013279239 hasAuthorship W2013279239A5026989749 @default.
- W2013279239 hasAuthorship W2013279239A5029259484 @default.
- W2013279239 hasAuthorship W2013279239A5060781921 @default.
- W2013279239 hasAuthorship W2013279239A5062498717 @default.
- W2013279239 hasConcept C104317684 @default.
- W2013279239 hasConcept C111441629 @default.
- W2013279239 hasConcept C185592680 @default.
- W2013279239 hasConcept C27740335 @default.
- W2013279239 hasConcept C2776601000 @default.
- W2013279239 hasConcept C2778250585 @default.
- W2013279239 hasConcept C2781121885 @default.
- W2013279239 hasConcept C55493867 @default.
- W2013279239 hasConcept C62112901 @default.
- W2013279239 hasConcept C86803240 @default.
- W2013279239 hasConcept C95444343 @default.
- W2013279239 hasConceptScore W2013279239C104317684 @default.
- W2013279239 hasConceptScore W2013279239C111441629 @default.
- W2013279239 hasConceptScore W2013279239C185592680 @default.
- W2013279239 hasConceptScore W2013279239C27740335 @default.
- W2013279239 hasConceptScore W2013279239C2776601000 @default.
- W2013279239 hasConceptScore W2013279239C2778250585 @default.
- W2013279239 hasConceptScore W2013279239C2781121885 @default.
- W2013279239 hasConceptScore W2013279239C55493867 @default.
- W2013279239 hasConceptScore W2013279239C62112901 @default.
- W2013279239 hasConceptScore W2013279239C86803240 @default.
- W2013279239 hasConceptScore W2013279239C95444343 @default.
- W2013279239 hasIssue "9" @default.
- W2013279239 hasLocation W20132792391 @default.
- W2013279239 hasLocation W20132792392 @default.
- W2013279239 hasOpenAccess W2013279239 @default.