FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013280990> ?p ?o ?g. }

• W2013280990 endingPage "4664" @default.
• W2013280990 startingPage "4654" @default.
• W2013280990 abstract "Cholinergic modulation of central circuits is associated with active sensation, attention, and learning, yet the neural circuits and temporal dynamics underlying cholinergic effects on sensory processing remain unclear. Understanding the effects of cholinergic modulation on particular circuits is complicated by the widespread projections of cholinergic neurons to telencephalic structures that themselves are highly interconnected. Here we examined how cholinergic projections from basal forebrain to the olfactory bulb (OB) modulate output from the first stage of sensory processing in the mouse olfactory system. By optogenetically activating their axons directly in the OB, we found that cholinergic projections from basal forebrain regulate OB output by increasing the spike output of presumptive mitral/tufted cells. Cholinergic stimulation increased mitral/tufted cell spiking in the absence of inhalation-driven sensory input and further increased spiking responses to inhalation of odorless air and to odorants. This modulation was rapid and transient, was dependent on local cholinergic signaling in the OB, and differed from modulation by optogenetic activation of cholinergic neurons in basal forebrain, which led to a mixture of mitral/tufted cell excitation and suppression. Finally, bulbar cholinergic enhancement of mitral/tufted cell odorant responses was robust and occurred independent of the strength or even polarity of the odorant-evoked response, indicating that cholinergic modulation adds an excitatory bias to mitral/tufted cells as opposed to increasing response gain or sharpening response spectra. These results are consistent with a role for the basal forebrain cholinergic system in dynamically regulating the sensitivity to or salience of odors during active sensing of the olfactory environment." @default.
• W2013280990 created "2016-06-24" @default.
• W2013280990 creator A5011022093 @default.
• W2013280990 creator A5039084536 @default.
• W2013280990 creator A5057413272 @default.
• W2013280990 creator A5061187034 @default.
• W2013280990 creator A5084889294 @default.
• W2013280990 date "2014-03-26" @default.
• W2013280990 modified "2023-10-12" @default.
• W2013280990 title "Cholinergic Inputs from Basal Forebrain Add an Excitatory Bias to Odor Coding in the Olfactory Bulb" @default.
• W2013280990 cites W1776441027 @default.
• W2013280990 cites W1954618583 @default.
• W2013280990 cites W1963686519 @default.
• W2013280990 cites W1964440976 @default.
• W2013280990 cites W1966698116 @default.
• W2013280990 cites W1966943727 @default.
• W2013280990 cites W1969650326 @default.
• W2013280990 cites W1970780368 @default.
• W2013280990 cites W1973193042 @default.
• W2013280990 cites W1973230208 @default.
• W2013280990 cites W1974509994 @default.
• W2013280990 cites W1977865303 @default.
• W2013280990 cites W1982088031 @default.
• W2013280990 cites W1987076552 @default.
• W2013280990 cites W1997387168 @default.
• W2013280990 cites W2000170413 @default.
• W2013280990 cites W2000816595 @default.
• W2013280990 cites W2003008250 @default.
• W2013280990 cites W2003068184 @default.
• W2013280990 cites W2006660223 @default.
• W2013280990 cites W2006688777 @default.
• W2013280990 cites W2010052734 @default.
• W2013280990 cites W2011325797 @default.
• W2013280990 cites W2011436438 @default.
• W2013280990 cites W2013665604 @default.
• W2013280990 cites W2013683414 @default.
• W2013280990 cites W2019700951 @default.
• W2013280990 cites W2024727777 @default.
• W2013280990 cites W2031786314 @default.
• W2013280990 cites W2036322060 @default.
• W2013280990 cites W2037820041 @default.
• W2013280990 cites W2039338324 @default.
• W2013280990 cites W2043063585 @default.
• W2013280990 cites W2046596175 @default.
• W2013280990 cites W2049481053 @default.
• W2013280990 cites W2060290604 @default.
• W2013280990 cites W2061921304 @default.
• W2013280990 cites W2062775959 @default.
• W2013280990 cites W2067463771 @default.
• W2013280990 cites W2068196163 @default.
• W2013280990 cites W2068679600 @default.
• W2013280990 cites W2069955367 @default.
• W2013280990 cites W2073088023 @default.
• W2013280990 cites W2078345652 @default.
• W2013280990 cites W2079810269 @default.
• W2013280990 cites W2079955486 @default.
• W2013280990 cites W2081350509 @default.
• W2013280990 cites W2086837225 @default.
• W2013280990 cites W2086991865 @default.
• W2013280990 cites W2090032446 @default.
• W2013280990 cites W2094291813 @default.
• W2013280990 cites W2095323652 @default.
• W2013280990 cites W2095536022 @default.
• W2013280990 cites W2097666239 @default.
• W2013280990 cites W2099689932 @default.
• W2013280990 cites W2100064861 @default.
• W2013280990 cites W2101491694 @default.
• W2013280990 cites W2104135721 @default.
• W2013280990 cites W2115442710 @default.
• W2013280990 cites W2118888847 @default.
• W2013280990 cites W2120729067 @default.
• W2013280990 cites W2121895272 @default.
• W2013280990 cites W2130041419 @default.
• W2013280990 cites W2130432173 @default.
• W2013280990 cites W2133756703 @default.
• W2013280990 cites W2148030712 @default.
• W2013280990 cites W2158024903 @default.
• W2013280990 cites W2158674796 @default.
• W2013280990 cites W2160274386 @default.
• W2013280990 cites W2162056177 @default.
• W2013280990 cites W2164952006 @default.
• W2013280990 cites W2167556574 @default.
• W2013280990 cites W2171919975 @default.
• W2013280990 cites W2306110306 @default.
• W2013280990 doi "https://doi.org/10.1523/jneurosci.5026-13.2014" @default.
• W2013280990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3965788" @default.
• W2013280990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24672011" @default.
• W2013280990 hasPublicationYear "2014" @default.
• W2013280990 type Work @default.
• W2013280990 sameAs 2013280990 @default.
• W2013280990 citedByCount "101" @default.
• W2013280990 countsByYear W20132809902014 @default.
• W2013280990 countsByYear W20132809902015 @default.
• W2013280990 countsByYear W20132809902016 @default.
• W2013280990 countsByYear W20132809902017 @default.
• W2013280990 countsByYear W20132809902018 @default.
• W2013280990 countsByYear W20132809902019 @default.
• W2013280990 countsByYear W20132809902020 @default.

• next