FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013282575> ?p ?o ?g. }

• W2013282575 endingPage "860" @default.
• W2013282575 startingPage "843" @default.
• W2013282575 abstract "Neurotrophins, such as NGF and BDNF, induce sustained activation of Rap1 small G protein and ERK, which are essential for neurite outgrowth. We show involvement of a GDP/GTP exchange factor (GEF) for Rap1, PDZ-GEF1, in these processes. PDZ-GEF1 is activated by GTP-Rap1 via a positive feedback mechanism. Upon NGF binding, the TrkA neurotrophin receptor is internalized from the cell surface, passes through early endosomes, and arrives in late endosomes. A tetrameric complex forms between PDZ-GEF1, synaptic scaffolding molecule and ankyrin repeat-rich membrane spanning protein which interacts directly with the TrkA receptor. At late endosomes, the complex induces sustained activation of Rap1 and ERK, resulting in neurite outgrowth. In cultured rat hippocampal neurons, PDZ-GEF1 is recruited to late endosomes in a BDNF-dependent manner involved in BDNF-induced neurite outgrowth. Thus, the interaction of PDZ-GEF1 with an internalized neurotrophin receptor transported to late endosomes induces sustained activation of both Rap1 and ERK and neurite outgrowth." @default.
• W2013282575 created "2016-06-24" @default.
• W2013282575 creator A5005532530 @default.
• W2013282575 creator A5018506413 @default.
• W2013282575 creator A5024220610 @default.
• W2013282575 creator A5026764864 @default.
• W2013282575 creator A5030195859 @default.
• W2013282575 creator A5042331400 @default.
• W2013282575 creator A5049590410 @default.
• W2013282575 date "2007-08-27" @default.
• W2013282575 modified "2023-09-24" @default.
• W2013282575 title "Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth" @default.
• W2013282575 cites W124239641 @default.
• W2013282575 cites W1498281052 @default.
• W2013282575 cites W1525183361 @default.
• W2013282575 cites W1543554885 @default.
• W2013282575 cites W1564404844 @default.
• W2013282575 cites W1667204010 @default.
• W2013282575 cites W1871356778 @default.
• W2013282575 cites W1891880696 @default.
• W2013282575 cites W1896838955 @default.
• W2013282575 cites W1920813350 @default.
• W2013282575 cites W1966386737 @default.
• W2013282575 cites W1971241138 @default.
• W2013282575 cites W1973059673 @default.
• W2013282575 cites W1976161959 @default.
• W2013282575 cites W1988398725 @default.
• W2013282575 cites W1989875198 @default.
• W2013282575 cites W1992426611 @default.
• W2013282575 cites W1994447633 @default.
• W2013282575 cites W1997814123 @default.
• W2013282575 cites W2001330472 @default.
• W2013282575 cites W2012415301 @default.
• W2013282575 cites W2012560446 @default.
• W2013282575 cites W2012839323 @default.
• W2013282575 cites W2013922032 @default.
• W2013282575 cites W2015172381 @default.
• W2013282575 cites W2019843044 @default.
• W2013282575 cites W2022730960 @default.
• W2013282575 cites W2029232232 @default.
• W2013282575 cites W2030204732 @default.
• W2013282575 cites W2030476245 @default.
• W2013282575 cites W2031872827 @default.
• W2013282575 cites W2031909809 @default.
• W2013282575 cites W2038917691 @default.
• W2013282575 cites W2040577472 @default.
• W2013282575 cites W2041938779 @default.
• W2013282575 cites W2044643509 @default.
• W2013282575 cites W2045153659 @default.
• W2013282575 cites W2048208090 @default.
• W2013282575 cites W2053713095 @default.
• W2013282575 cites W2055523552 @default.
• W2013282575 cites W2059346427 @default.
• W2013282575 cites W2063120457 @default.
• W2013282575 cites W2064265756 @default.
• W2013282575 cites W2067005574 @default.
• W2013282575 cites W2070325241 @default.
• W2013282575 cites W2076261991 @default.
• W2013282575 cites W2081944049 @default.
• W2013282575 cites W2083063047 @default.
• W2013282575 cites W2086617915 @default.
• W2013282575 cites W2089512569 @default.
• W2013282575 cites W2102434171 @default.
• W2013282575 cites W2117356422 @default.
• W2013282575 cites W2117506103 @default.
• W2013282575 cites W2131832714 @default.
• W2013282575 cites W2133966135 @default.
• W2013282575 cites W2136572232 @default.
• W2013282575 cites W2138420027 @default.
• W2013282575 cites W2139278282 @default.
• W2013282575 cites W2139565721 @default.
• W2013282575 cites W2142458084 @default.
• W2013282575 cites W2143086493 @default.
• W2013282575 cites W2146173859 @default.
• W2013282575 cites W2150317682 @default.
• W2013282575 cites W2155384802 @default.
• W2013282575 cites W2157918194 @default.
• W2013282575 cites W2164354034 @default.
• W2013282575 cites W2170114979 @default.
• W2013282575 cites W2170467038 @default.
• W2013282575 doi "https://doi.org/10.1083/jcb.200610073" @default.
• W2013282575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064548" @default.
• W2013282575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17724123" @default.
• W2013282575 hasPublicationYear "2007" @default.
• W2013282575 type Work @default.
• W2013282575 sameAs 2013282575 @default.
• W2013282575 citedByCount "111" @default.
• W2013282575 countsByYear W20132825752012 @default.
• W2013282575 countsByYear W20132825752013 @default.
• W2013282575 countsByYear W20132825752014 @default.
• W2013282575 countsByYear W20132825752015 @default.
• W2013282575 countsByYear W20132825752016 @default.
• W2013282575 countsByYear W20132825752017 @default.
• W2013282575 countsByYear W20132825752018 @default.
• W2013282575 countsByYear W20132825752019 @default.
• W2013282575 countsByYear W20132825752020 @default.
• W2013282575 countsByYear W20132825752021 @default.
• W2013282575 countsByYear W20132825752022 @default.

• next