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• W2013285760 startingPage "417" @default.
• W2013285760 abstract "Microvilli are actin-based fingerlike membrane projections that form the basis of the brush border of enterocytes and the Drosophila melanogaster photoreceptor rhabdomere. Although many microvillar cytoskeletal components have been identified, the molecular basis of microvillus formation is largely undefined. Here, we report that the Wiskott-Aldrich syndrome protein (WASp) is necessary for rhabdomere microvillus morphogenesis. We show that WASp accumulates on the photoreceptor apical surface before microvillus formation, and at the time of microvillus initiation WASp colocalizes with amphiphysin and moesin. The loss of WASp delays the enrichment of F-actin on the apical photoreceptor surface, delays the appearance of the primordial microvillar projections, and subsequently leads to malformed rhabdomeres." @default.
• W2013285760 created "2016-06-24" @default.
• W2013285760 creator A5057225054 @default.
• W2013285760 creator A5061621933 @default.
• W2013285760 date "2004-01-26" @default.
• W2013285760 modified "2023-09-25" @default.
• W2013285760 title "WASp is required for the correct temporal morphogenesis of rhabdomere microvilli" @default.
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• W2013285760 doi "https://doi.org/10.1083/jcb.200307048" @default.
• W2013285760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2172231" @default.
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