FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013289769> ?p ?o ?g. }

• W2013289769 abstract "Abstract Background Among the members of the genus Bordetella B. petrii is unique, since it is the only species isolated from the environment, while the pathogenic Bordetellae are obligately associated with host organisms. Another feature distinguishing B. petrii from the other sequenced Bordetellae is the presence of a large number of mobile genetic elements including several large genomic regions with typical characteristics of genomic islands collectively known as integrative and conjugative elements (ICEs). These elements mainly encode accessory metabolic factors enabling this bacterium to grow on a large repertoire of aromatic compounds. Results During in vitro culture of Bordetella petrii colony variants appear frequently. We show that this variability can be attributed to the presence of a large number of metastable mobile genetic elements on its chromosome. In fact, the genome sequence of B. petrii revealed the presence of at least seven large genomic islands mostly encoding accessory metabolic functions involved in the degradation of aromatic compounds and detoxification of heavy metals. Four of these islands (termed GI1 to GI3 and GI6) are highly related to ICE clc of Pseudomonas knackmussii sp. strain B13. Here we present first data about the molecular characterization of these islands. We defined the exact borders of each island and we show that during standard culture of the bacteria these islands get excised from the chromosome. For all but one of these islands (GI5) we could detect circular intermediates. For the clc -like elements GI1 to GI3 of B. petrii we provide evidence that tandem insertion of these islands which all encode highly related integrases and attachment sites may also lead to incorporation of genomic DNA which originally was not part of the island and to the formation of huge composite islands. By integration of a tetracycline resistance cassette into GI3 we found this island to be rather unstable and to be lost from the bacterial population within about 100 consecutive generations. Furthermore, we show that GI3 is self transmissible and by conjugation can be transferred to B. bronchiseptica thus proving it to be an active integrative and conjugative element Conclusion The results show that phenotypic variation of B. petrii is correlated with the presence of genomic islands. Tandem integration of related islands may contribute to island evolution by the acquisition of genes originally belonging to the bacterial core genome. In conclusion, B. petrii appears to be the first member of the genus in which horizontal gene transfer events have massively shaped its genome structure." @default.
• W2013289769 created "2016-06-24" @default.
• W2013289769 creator A5007931791 @default.
• W2013289769 creator A5009991935 @default.
• W2013289769 creator A5014629042 @default.
• W2013289769 creator A5029750346 @default.
• W2013289769 creator A5042864131 @default.
• W2013289769 creator A5051111501 @default.
• W2013289769 creator A5067815763 @default.
• W2013289769 creator A5067997737 @default.
• W2013289769 creator A5087541434 @default.
• W2013289769 date "2009-07-18" @default.
• W2013289769 modified "2023-09-26" @default.
• W2013289769 title "Genomic island excisions in Bordetella petrii" @default.
• W2013289769 cites W1517723110 @default.
• W2013289769 cites W1931775341 @default.
• W2013289769 cites W1968146772 @default.
• W2013289769 cites W1994670764 @default.
• W2013289769 cites W2027031393 @default.
• W2013289769 cites W2035036761 @default.
• W2013289769 cites W2035620569 @default.
• W2013289769 cites W2040961869 @default.
• W2013289769 cites W2047544081 @default.
• W2013289769 cites W2050896642 @default.
• W2013289769 cites W2071408245 @default.
• W2013289769 cites W2078658531 @default.
• W2013289769 cites W2092035974 @default.
• W2013289769 cites W2099821049 @default.
• W2013289769 cites W2109355308 @default.
• W2013289769 cites W2128157441 @default.
• W2013289769 cites W2131378221 @default.
• W2013289769 cites W2139180895 @default.
• W2013289769 cites W2143414315 @default.
• W2013289769 cites W2144178165 @default.
• W2013289769 cites W2151183612 @default.
• W2013289769 cites W2151407723 @default.
• W2013289769 cites W2155140989 @default.
• W2013289769 cites W2155286911 @default.
• W2013289769 cites W2155534524 @default.
• W2013289769 cites W2156007347 @default.
• W2013289769 cites W2160603814 @default.
• W2013289769 cites W2171396485 @default.
• W2013289769 doi "https://doi.org/10.1186/1471-2180-9-141" @default.
• W2013289769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2717098" @default.
• W2013289769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19615092" @default.
• W2013289769 hasPublicationYear "2009" @default.
• W2013289769 type Work @default.
• W2013289769 sameAs 2013289769 @default.
• W2013289769 citedByCount "33" @default.
• W2013289769 countsByYear W20132897692012 @default.
• W2013289769 countsByYear W20132897692013 @default.
• W2013289769 countsByYear W20132897692014 @default.
• W2013289769 countsByYear W20132897692016 @default.
• W2013289769 countsByYear W20132897692017 @default.
• W2013289769 countsByYear W20132897692019 @default.
• W2013289769 countsByYear W20132897692020 @default.
• W2013289769 countsByYear W20132897692021 @default.
• W2013289769 countsByYear W20132897692022 @default.
• W2013289769 countsByYear W20132897692023 @default.
• W2013289769 crossrefType "journal-article" @default.
• W2013289769 hasAuthorship W2013289769A5007931791 @default.
• W2013289769 hasAuthorship W2013289769A5009991935 @default.
• W2013289769 hasAuthorship W2013289769A5014629042 @default.
• W2013289769 hasAuthorship W2013289769A5029750346 @default.
• W2013289769 hasAuthorship W2013289769A5042864131 @default.
• W2013289769 hasAuthorship W2013289769A5051111501 @default.
• W2013289769 hasAuthorship W2013289769A5067815763 @default.
• W2013289769 hasAuthorship W2013289769A5067997737 @default.
• W2013289769 hasAuthorship W2013289769A5087541434 @default.
• W2013289769 hasBestOaLocation W20132897691 @default.
• W2013289769 hasConcept C104317684 @default.
• W2013289769 hasConcept C132533263 @default.
• W2013289769 hasConcept C141231307 @default.
• W2013289769 hasConcept C157887575 @default.
• W2013289769 hasConcept C2780258820 @default.
• W2013289769 hasConcept C2909909245 @default.
• W2013289769 hasConcept C4918238 @default.
• W2013289769 hasConcept C54355233 @default.
• W2013289769 hasConcept C86803240 @default.
• W2013289769 hasConcept C92938381 @default.
• W2013289769 hasConceptScore W2013289769C104317684 @default.
• W2013289769 hasConceptScore W2013289769C132533263 @default.
• W2013289769 hasConceptScore W2013289769C141231307 @default.
• W2013289769 hasConceptScore W2013289769C157887575 @default.
• W2013289769 hasConceptScore W2013289769C2780258820 @default.
• W2013289769 hasConceptScore W2013289769C2909909245 @default.
• W2013289769 hasConceptScore W2013289769C4918238 @default.
• W2013289769 hasConceptScore W2013289769C54355233 @default.
• W2013289769 hasConceptScore W2013289769C86803240 @default.
• W2013289769 hasConceptScore W2013289769C92938381 @default.
• W2013289769 hasIssue "1" @default.
• W2013289769 hasLocation W20132897691 @default.
• W2013289769 hasLocation W20132897692 @default.
• W2013289769 hasLocation W20132897693 @default.
• W2013289769 hasLocation W20132897694 @default.
• W2013289769 hasOpenAccess W2013289769 @default.
• W2013289769 hasPrimaryLocation W20132897691 @default.
• W2013289769 hasRelatedWork W1989898630 @default.
• W2013289769 hasRelatedWork W2031673350 @default.
• W2013289769 hasRelatedWork W2037702752 @default.

• next