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• W2013292414 abstract "Many different 3α-hydroxysteroids in the androstane and pregnane steroid series enhance the actions of γ-aminobutyric acid (GABA) at GABA type-A (GABAA) receptors in the mammalian central nervous system. Recent studies have shown that (3α,5α)-3-hydroxyandrostan-17-one (androsterone) is less active at these receptors than its enantiomer ent-androsterone. Further structure–activity relationship (SAR) studies are needed to explore the structural features of ent-androsterone that are important for its enhanced action at these receptors. Molecular modeling shows that 2β-hydroxysteroids are similar in three-dimensional shape to the enantiomers of 3α-hydroxysteroids. The development of synthetic methods to gain access to C17-substituted analogues of 2β-hydroxygonanes for SAR studies is demonstrated with the synthesis of (2β,5α,14β)-2-hydroxygonan-17-one." @default.
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• W2013292414 date "2007-08-01" @default.
• W2013292414 modified "2023-09-23" @default.
• W2013292414 title "Neurosteroid analogues. Part 13: Synthetic methods for the preparation of 2β-hydroxygonane derivatives as structural mimics of ent-3α-hydroxysteroid modulators of GABAA receptors" @default.
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• W2013292414 doi "https://doi.org/10.1016/j.tet.2007.05.068" @default.
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