FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013294539> ?p ?o ?g. }

• W2013294539 endingPage "144" @default.
• W2013294539 startingPage "135" @default.
• W2013294539 abstract "Disheveled (Dvl) is a key regulator of both the canonical Wnt and the planar cell polarity (PCP) pathway. Previous genetic studies in mice indicated that outflow tract (OFT) formation requires Dvl1 and 2, but it was unclear which pathway was involved and whether Dvl1/2-mediated signaling was required in the second heart field (SHF) or the cardiac neural crest (CNC) lineage, both of which are critical for OFT development. In this study, we used Dvl1/2 null mice and a set of Dvl2 BAC transgenes that function in a pathway-specific fashion to demonstrate that Dvl1/2-mediated PCP signaling is essential for OFT formation. Lineage-specific gene-ablation further indicated that Dvl1/2 function is dispensable in the CNC, but required in the SHF for OFT lengthening to promote cardiac looping. Mutating the core PCP gene Vangl2 and non-canonical Wnt gene Wnt5a recapitulated the OFT morphogenesis defects observed in Dvl1/2 mutants. Consistent with genetic interaction studies suggesting that Wnt5a signals through the PCP pathway, Dvl1/2 and Wnt5a mutants display aberrant cell packing and defective actin polymerization and filopodia formation specifically in SHF cells in the caudal splanchnic mesoderm (SpM), where Wnt5a and Dvl2 are co-expressed specifically. Our results reveal a critical role of PCP signaling in the SHF during early OFT lengthening and cardiac looping and suggest that a Wnt5a→ Dvl PCP signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal SpM to promote SHF deployment, OFT lengthening and cardiac looping." @default.
• W2013294539 created "2016-06-24" @default.
• W2013294539 creator A5013244136 @default.
• W2013294539 creator A5040040696 @default.
• W2013294539 creator A5062693978 @default.
• W2013294539 creator A5068549728 @default.
• W2013294539 creator A5077737100 @default.
• W2013294539 date "2012-10-01" @default.
• W2013294539 modified "2023-10-15" @default.
• W2013294539 title "Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis" @default.
• W2013294539 cites W1542932778 @default.
• W2013294539 cites W1573866353 @default.
• W2013294539 cites W1931060259 @default.
• W2013294539 cites W1965271063 @default.
• W2013294539 cites W1966030396 @default.
• W2013294539 cites W1966563415 @default.
• W2013294539 cites W1967444593 @default.
• W2013294539 cites W1973180710 @default.
• W2013294539 cites W1974712344 @default.
• W2013294539 cites W1975456228 @default.
• W2013294539 cites W1975709809 @default.
• W2013294539 cites W1976093363 @default.
• W2013294539 cites W1976401025 @default.
• W2013294539 cites W1978928064 @default.
• W2013294539 cites W1991014863 @default.
• W2013294539 cites W1991671544 @default.
• W2013294539 cites W1993199560 @default.
• W2013294539 cites W1994465080 @default.
• W2013294539 cites W1995946981 @default.
• W2013294539 cites W1996021785 @default.
• W2013294539 cites W1996847587 @default.
• W2013294539 cites W1998066648 @default.
• W2013294539 cites W1998389437 @default.
• W2013294539 cites W2001448821 @default.
• W2013294539 cites W2002732720 @default.
• W2013294539 cites W2003959047 @default.
• W2013294539 cites W2006671195 @default.
• W2013294539 cites W2008127822 @default.
• W2013294539 cites W2008205503 @default.
• W2013294539 cites W2012517517 @default.
• W2013294539 cites W2015766782 @default.
• W2013294539 cites W2021346518 @default.
• W2013294539 cites W2025860724 @default.
• W2013294539 cites W2030683556 @default.
• W2013294539 cites W2039117468 @default.
• W2013294539 cites W2039348587 @default.
• W2013294539 cites W2042773729 @default.
• W2013294539 cites W2043912973 @default.
• W2013294539 cites W2045577258 @default.
• W2013294539 cites W2045751117 @default.
• W2013294539 cites W2050223736 @default.
• W2013294539 cites W2051026229 @default.
• W2013294539 cites W2055104213 @default.
• W2013294539 cites W2055191807 @default.
• W2013294539 cites W2055557491 @default.
• W2013294539 cites W2057262868 @default.
• W2013294539 cites W2057953361 @default.
• W2013294539 cites W2058172887 @default.
• W2013294539 cites W2070895882 @default.
• W2013294539 cites W2072392892 @default.
• W2013294539 cites W2079289510 @default.
• W2013294539 cites W2080433725 @default.
• W2013294539 cites W2084972992 @default.
• W2013294539 cites W2086484705 @default.
• W2013294539 cites W2090056454 @default.
• W2013294539 cites W2095189716 @default.
• W2013294539 cites W2097375811 @default.
• W2013294539 cites W2098067206 @default.
• W2013294539 cites W2100162103 @default.
• W2013294539 cites W2120609231 @default.
• W2013294539 cites W2120983879 @default.
• W2013294539 cites W2133245568 @default.
• W2013294539 cites W2138959037 @default.
• W2013294539 cites W2146117781 @default.
• W2013294539 cites W2148037744 @default.
• W2013294539 cites W2149429346 @default.
• W2013294539 cites W2152241642 @default.
• W2013294539 cites W2153159943 @default.
• W2013294539 cites W2155582359 @default.
• W2013294539 cites W2155956254 @default.
• W2013294539 cites W2158910153 @default.
• W2013294539 cites W2160582164 @default.
• W2013294539 cites W2167179112 @default.
• W2013294539 doi "https://doi.org/10.1016/j.ydbio.2012.07.023" @default.
• W2013294539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3432663" @default.
• W2013294539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22841628" @default.
• W2013294539 hasPublicationYear "2012" @default.
• W2013294539 type Work @default.
• W2013294539 sameAs 2013294539 @default.
• W2013294539 citedByCount "66" @default.
• W2013294539 countsByYear W20132945392013 @default.
• W2013294539 countsByYear W20132945392014 @default.
• W2013294539 countsByYear W20132945392015 @default.
• W2013294539 countsByYear W20132945392016 @default.
• W2013294539 countsByYear W20132945392017 @default.
• W2013294539 countsByYear W20132945392018 @default.
• W2013294539 countsByYear W20132945392019 @default.
• W2013294539 countsByYear W20132945392020 @default.

• next