FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013295964> ?p ?o ?g. }

• W2013295964 endingPage "349" @default.
• W2013295964 startingPage "338" @default.
• W2013295964 abstract "Summary Overexpression of high mobility group AT‐hook 2 ( Hmga2 ), which is negatively regulated by MIRLET7 micro RNAs through 3′‐untranslated region (3′UTR), causes proliferative haematopoiesis mimicking myeloproliferative neoplasms (MPNs) and contributes to progression of myelofibrosis in mice. Thus, we investigated HMGA2 mRNA expression in 66 patients with MPNs including 23 polycythaemia vera (PV), 33 essential thrombocythaemia (ET) and 10 primary myelofibrosis (PMF). HMGA2 mRNA expression, especially variant 1 with 3′UTR that contains MIRLET7 ‐specific sites, rather than variant 2 lacking 3′UTR, is frequently deregulated due to decreased MIRLET7 expression in granulocytes from over 20% of PV and ET, and in either granulocytes or CD34 + cells from 100% of PMF. Patients with deregulated HMGA2 mRNA expression were significantly more likely to show splenomegaly, high serum lactate dehydrogenase values, and methylation of the CDKN2A promoter compared with other patients without deregulation of HMGA2 . A histone deacetylase inhibitor, panobinostat, significantly increased MIRLET7 expression and reduced variant 1 of HMGA2 mRNA expression, but not variant 2, in both U937 cells and PMF‐derived CD34 + cells. Moreover, both panobinostat and small interfering RNA of HMGA2 demethylated the CDKN2A promoter in U937 cells. In conclusion, the frequently dysregulated MIRLET7 / HMGA2 axis could be a therapeutic target in MPNs." @default.
• W2013295964 created "2016-06-24" @default.
• W2013295964 creator A5004466344 @default.
• W2013295964 creator A5020450821 @default.
• W2013295964 creator A5024928427 @default.
• W2013295964 creator A5031116384 @default.
• W2013295964 creator A5051244269 @default.
• W2013295964 creator A5054057203 @default.
• W2013295964 creator A5054154446 @default.
• W2013295964 creator A5063901740 @default.
• W2013295964 creator A5069877596 @default.
• W2013295964 creator A5071399205 @default.
• W2013295964 date "2014-09-19" @default.
• W2013295964 modified "2023-10-04" @default.
• W2013295964 title "Dysregulation of the<i>MIRLET7</i>/<i>HMGA2</i>axis with methylation of the<i>CDKN2A</i>promoter in myeloproliferative neoplasms" @default.
• W2013295964 cites W1754059962 @default.
• W2013295964 cites W1873772500 @default.
• W2013295964 cites W1963679004 @default.
• W2013295964 cites W1968610219 @default.
• W2013295964 cites W1968951172 @default.
• W2013295964 cites W1976533267 @default.
• W2013295964 cites W1977037602 @default.
• W2013295964 cites W1980568348 @default.
• W2013295964 cites W1980642919 @default.
• W2013295964 cites W1981888767 @default.
• W2013295964 cites W1995149934 @default.
• W2013295964 cites W1995384340 @default.
• W2013295964 cites W1998655695 @default.
• W2013295964 cites W2009229545 @default.
• W2013295964 cites W2009842916 @default.
• W2013295964 cites W2014929974 @default.
• W2013295964 cites W2025124131 @default.
• W2013295964 cites W2028919540 @default.
• W2013295964 cites W2029318743 @default.
• W2013295964 cites W2032230630 @default.
• W2013295964 cites W2037995476 @default.
• W2013295964 cites W2046982014 @default.
• W2013295964 cites W2049145190 @default.
• W2013295964 cites W2057360098 @default.
• W2013295964 cites W2059851299 @default.
• W2013295964 cites W2062145659 @default.
• W2013295964 cites W2063544405 @default.
• W2013295964 cites W2072177644 @default.
• W2013295964 cites W2079879959 @default.
• W2013295964 cites W2088115866 @default.
• W2013295964 cites W2092627970 @default.
• W2013295964 cites W2098379349 @default.
• W2013295964 cites W2102012932 @default.
• W2013295964 cites W2106122801 @default.
• W2013295964 cites W2106670703 @default.
• W2013295964 cites W2107398329 @default.
• W2013295964 cites W2115351357 @default.
• W2013295964 cites W2115400483 @default.
• W2013295964 cites W2125916700 @default.
• W2013295964 cites W2126701902 @default.
• W2013295964 cites W2138606289 @default.
• W2013295964 cites W2138709799 @default.
• W2013295964 cites W2143039662 @default.
• W2013295964 cites W2144664431 @default.
• W2013295964 cites W2157694607 @default.
• W2013295964 cites W2159249303 @default.
• W2013295964 cites W2161142016 @default.
• W2013295964 cites W2165737158 @default.
• W2013295964 cites W2170647698 @default.
• W2013295964 cites W2171523100 @default.
• W2013295964 cites W4229780401 @default.
• W2013295964 doi "https://doi.org/10.1111/bjh.13129" @default.
• W2013295964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25236537" @default.
• W2013295964 hasPublicationYear "2014" @default.
• W2013295964 type Work @default.
• W2013295964 sameAs 2013295964 @default.
• W2013295964 citedByCount "22" @default.
• W2013295964 countsByYear W20132959642015 @default.
• W2013295964 countsByYear W20132959642016 @default.
• W2013295964 countsByYear W20132959642017 @default.
• W2013295964 countsByYear W20132959642019 @default.
• W2013295964 countsByYear W20132959642020 @default.
• W2013295964 countsByYear W20132959642021 @default.
• W2013295964 crossrefType "journal-article" @default.
• W2013295964 hasAuthorship W2013295964A5004466344 @default.
• W2013295964 hasAuthorship W2013295964A5020450821 @default.
• W2013295964 hasAuthorship W2013295964A5024928427 @default.
• W2013295964 hasAuthorship W2013295964A5031116384 @default.
• W2013295964 hasAuthorship W2013295964A5051244269 @default.
• W2013295964 hasAuthorship W2013295964A5054057203 @default.
• W2013295964 hasAuthorship W2013295964A5054154446 @default.
• W2013295964 hasAuthorship W2013295964A5063901740 @default.
• W2013295964 hasAuthorship W2013295964A5069877596 @default.
• W2013295964 hasAuthorship W2013295964A5071399205 @default.
• W2013295964 hasBestOaLocation W20132959642 @default.
• W2013295964 hasConcept C104317684 @default.
• W2013295964 hasConcept C105580179 @default.
• W2013295964 hasConcept C145059251 @default.
• W2013295964 hasConcept C153911025 @default.
• W2013295964 hasConcept C203014093 @default.
• W2013295964 hasConcept C2529059 @default.
• W2013295964 hasConcept C2780007613 @default.
• W2013295964 hasConcept C2780076729 @default.

• next