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- W2013296083 abstract "We tested here the hypothesis that the pharmacological modulation of the mitochondrial Na+/Ca2+ exchanger (mNCX) could be a new neuroprotective strategy to rescue stressed vulnerable neurons from death. We used rat hippocampal slices incubated with veratridine to cause neuronal death through a mechanism involving Na+ and Ca2+ overload. CGP37157 (CGP), an inhibitor of the mNCX, rescued veratridine vulnerable neurons from death, showing an EC50 of 5 μM. This neuroprotection was associated to mitigation of veratridine-elicited overproduction of free radicals and to inhibition of the p38 MAPK-linked apoptotic pathway. These results suggest that the mNCX could become a new target to develop compounds with potential therapeutic neuroprotective actions in neurodegenerative diseases." @default.
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- W2013296083 date "2010-09-01" @default.
- W2013296083 modified "2023-10-08" @default.
- W2013296083 title "Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices" @default.
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- W2013296083 doi "https://doi.org/10.1016/j.bbrc.2010.08.028" @default.
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