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- W2013296722 abstract "Sulphasalazine (SZ) inhibits prostaglandin (PG) biosynthesis in vitro with a potency comparable to that of aceylsalicylate. The metabolites of SZ, sulphapyridine and 5-aminosalicylic acid, were of considerably lower potency as inhibitors of PG biosynthesis in the synthetase preparations used. The inhibition of prostaglandin production by SZ could at least partly account for the clinical utility of sulphasalazine in ulcerative colitis. Sulphapyridine may help to maintain inhibitory concentrations of SZ by restraining bacterial breakdown of the active drug." @default.
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- W2013296722 date "1976-02-01" @default.
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- W2013296722 title "Inhibition of prostaglandin biosynthesis by sulphasalazine and its metabolites" @default.
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- W2013296722 doi "https://doi.org/10.1016/0090-6980(76)90145-3" @default.
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