Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013298631> ?p ?o ?g. }
- W2013298631 endingPage "1677" @default.
- W2013298631 startingPage "1664" @default.
- W2013298631 abstract "High-fidelity chromosome transmission is fundamental in controlling the quality of the cell division cycle. The spindle pole-to-pole distance remains constant from metaphase to anaphase A. We show that fission yeast sister centromere-connecting proteins, Mis6 and Mis12, are required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in mis6 and mis12 mutants. This may be due to incorrect spindle morphogenesis containing impaired sister centromeres or force unbalance between pulling by the linked sister kinetochores and kinetochore-independent pushing. The mutant spindle fully extends in anaphase, although it is accompanied by drastic missegregation by aberrant sister centromere separation. Hence, metaphase spindle length may be crucial for segregation fidelity. Suppressors of mis12 partly restore normal metaphase spindle length. In mis4 that is defective in sister chromatid cohesion, metaphase spindle length is also long, but anaphase spindle extension is blocked, probably due to the activated spindle checkpoint. Extensive missegregation is caused in mis12 only when Mis12 is inactivated from the previous M through to the following M, an effective way to avoid missegregation in the cell cycle. Mis12 has conserved homologs in budding yeast and filamentous fungi." @default.
- W2013298631 created "2016-06-24" @default.
- W2013298631 creator A5004377531 @default.
- W2013298631 creator A5025518989 @default.
- W2013298631 creator A5079156355 @default.
- W2013298631 date "1999-07-01" @default.
- W2013298631 modified "2023-10-18" @default.
- W2013298631 title "Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation" @default.
- W2013298631 cites W1508414663 @default.
- W2013298631 cites W1537782690 @default.
- W2013298631 cites W1679767961 @default.
- W2013298631 cites W1963648581 @default.
- W2013298631 cites W1967920462 @default.
- W2013298631 cites W1971378151 @default.
- W2013298631 cites W1977034044 @default.
- W2013298631 cites W1979524912 @default.
- W2013298631 cites W1980637163 @default.
- W2013298631 cites W1981928248 @default.
- W2013298631 cites W1983412918 @default.
- W2013298631 cites W1986395573 @default.
- W2013298631 cites W1988573682 @default.
- W2013298631 cites W1990634825 @default.
- W2013298631 cites W1993220753 @default.
- W2013298631 cites W1995653496 @default.
- W2013298631 cites W2003848087 @default.
- W2013298631 cites W2005717642 @default.
- W2013298631 cites W2007755820 @default.
- W2013298631 cites W2011540715 @default.
- W2013298631 cites W2015989803 @default.
- W2013298631 cites W2016019304 @default.
- W2013298631 cites W2019068828 @default.
- W2013298631 cites W2029222292 @default.
- W2013298631 cites W2029234227 @default.
- W2013298631 cites W2029301727 @default.
- W2013298631 cites W2031115867 @default.
- W2013298631 cites W2033646526 @default.
- W2013298631 cites W2040433610 @default.
- W2013298631 cites W2042464607 @default.
- W2013298631 cites W2042901082 @default.
- W2013298631 cites W2047156618 @default.
- W2013298631 cites W2047458668 @default.
- W2013298631 cites W2048735610 @default.
- W2013298631 cites W2054337761 @default.
- W2013298631 cites W2059428026 @default.
- W2013298631 cites W2060385362 @default.
- W2013298631 cites W2065631676 @default.
- W2013298631 cites W2068141631 @default.
- W2013298631 cites W2069089403 @default.
- W2013298631 cites W2070125667 @default.
- W2013298631 cites W2071391879 @default.
- W2013298631 cites W2071941585 @default.
- W2013298631 cites W2083252398 @default.
- W2013298631 cites W2086081150 @default.
- W2013298631 cites W2091502861 @default.
- W2013298631 cites W2091547495 @default.
- W2013298631 cites W2096864462 @default.
- W2013298631 cites W2097201830 @default.
- W2013298631 cites W2098141162 @default.
- W2013298631 cites W2099152453 @default.
- W2013298631 cites W2106869142 @default.
- W2013298631 cites W2120917736 @default.
- W2013298631 cites W2123869586 @default.
- W2013298631 cites W2131663005 @default.
- W2013298631 cites W2132899445 @default.
- W2013298631 cites W2139164174 @default.
- W2013298631 cites W2146084258 @default.
- W2013298631 cites W2152414953 @default.
- W2013298631 cites W2167102182 @default.
- W2013298631 cites W2167257739 @default.
- W2013298631 cites W2169441156 @default.
- W2013298631 cites W2236011578 @default.
- W2013298631 cites W2311110868 @default.
- W2013298631 cites W54260994 @default.
- W2013298631 cites W95050424 @default.
- W2013298631 doi "https://doi.org/10.1101/gad.13.13.1664" @default.
- W2013298631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316848" @default.
- W2013298631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10398680" @default.
- W2013298631 hasPublicationYear "1999" @default.
- W2013298631 type Work @default.
- W2013298631 sameAs 2013298631 @default.
- W2013298631 citedByCount "199" @default.
- W2013298631 countsByYear W20132986312012 @default.
- W2013298631 countsByYear W20132986312013 @default.
- W2013298631 countsByYear W20132986312014 @default.
- W2013298631 countsByYear W20132986312015 @default.
- W2013298631 countsByYear W20132986312016 @default.
- W2013298631 countsByYear W20132986312017 @default.
- W2013298631 countsByYear W20132986312018 @default.
- W2013298631 countsByYear W20132986312019 @default.
- W2013298631 countsByYear W20132986312020 @default.
- W2013298631 countsByYear W20132986312021 @default.
- W2013298631 countsByYear W20132986312022 @default.
- W2013298631 countsByYear W20132986312023 @default.
- W2013298631 crossrefType "journal-article" @default.
- W2013298631 hasAuthorship W2013298631A5004377531 @default.
- W2013298631 hasAuthorship W2013298631A5025518989 @default.
- W2013298631 hasAuthorship W2013298631A5079156355 @default.
- W2013298631 hasBestOaLocation W20132986311 @default.