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• W2013300635 startingPage "457" @default.
• W2013300635 abstract "Only a small population (25–30%) of human peripheral blood B lymphocytes expresses large sialoglycoprotein (LSGP) (CD43). However, in the presence of autologous T cells and pokeweed mitogen (PWM) a majority (50–90%) of the immunoglobulin-producing cells (cÍg+ cells) that develop from these B cells express CD43 is detected with anti-CD43 monoclonal antibodies (MoAb) B1B6, and the proportion of CD43+cIg+ cells increases with time of culture. Furthermore, a relatively larger proportion (60–80%) of the IgG-producing cIg+ cells are CD43+ compared with IgM-containing cIg+ cells (30–50%). In human tonsils, signficantly more CD43+ cells (35%) are found in the in vivo-activated fraction of B cells than in the fraction of resting B cells (5%). A majority of the cIg+ cells that develop from the resting or the in vivo-activated tonsillar B cells in a PWM-induced B-cell differentiation system are CD43+ (80–100%). Furthermore, tonsillar B cells depleted of CD43+ cells give rise to cIg+ cells, of which the majority are CD43+, and the proportion of such cells increases with time of culture (60–90%). Taken together, these results indicate that LSGP belongs to a group of B-cell membrane molecules that are induced and upregulated upon activation and differentiation." @default.
• W2013300635 created "2016-06-24" @default.
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• W2013300635 date "1988-10-01" @default.
• W2013300635 modified "2023-10-13" @default.
• W2013300635 title "Induction of CD43 Expression during Activation and Terminal Differentiation of Human B Cells" @default.
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• W2013300635 doi "https://doi.org/10.1111/j.1365-3083.1988.tb01476.x" @default.
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