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- W2013301343 abstract "Background: Subacute hepatic failure (SAHF) is a complicationof acute hepatitis (AH) characterized by progressive jaundiceand development of ascites within 24 weeks of the onset oficterus. Its pathogenesis is unknown and its treatment isunsatisfactory. This study highlights on the possiblepathogenesis of the disease.Materials and methods: Thirty-two with SAHF among 798patients of AH who had tests for markers of acute hepatitis A,B, C and E had blood and ascitic fluid study and ultrasonogram(US) of liver. US and risk factors for infection were comparedwith consecutive uncomplicated AH. Blood culture was done inconsecutive 307 AH patients at the time of the first visit. Patientswith SAHF and control were followed for at least 6 months.Results: SAHF developed in 4% of the patients with AH.Bacteremia was detected in 50% and ascitic fluid showedfeatures of hepatic venous outflow obstruction (HVOO) andbacterial peritonitis. Thrombus was detected in IVC in all.Seventy-five percent of the patients who received antibioticrecovered. Recurrence of the symptoms in five and developmentof cirrhosis in seven patients were noted at follow-up but noneamong patients with uncomplicated acute hepatitis (AH).Bacteremia was also detected in 25% of consecutive AHpatients presenting with fever, with high incidence in those withcomplications.Conclusion: Bacteremia was common among patients withAH. Clinical features of SAHF could be explained by occurrencesuperadded bacterial infection that caused thrombophlebitis ofhepatic portion of the IVC resulting in HVOO.Abbreviations: AHF: Acute hepatic failure; CH: Chronichepatitis; AH: Acute hepatitis; SAHF: Subacute hepatic failure;ULN: Upper limit of normal; ALT: Alanine aminotransferase;AP: Alkaline phosphate; HA: Hepatitis A; HB: Hepatitis B; HC:Hepatitis C; HE: Hepatitis E; HVSC: Hepatic vena cavasyndrome; US: Ultrasonography; IVC: Inferior vena cava; LPS:Lipopoly sachcharides; BN: Bridging necrosis; HVOO: Hepaticvenous outflow obstruction." @default.
- W2013301343 created "2016-06-24" @default.
- W2013301343 creator A5082425282 @default.
- W2013301343 date "2012-01-01" @default.
- W2013301343 modified "2023-09-30" @default.
- W2013301343 title "Subacute Hepatic Failure: Its Possible Pathogenesis" @default.
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- W2013301343 doi "https://doi.org/10.5005/jp-journals-10018-1030" @default.
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