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- W2013301971 abstract "Rabbits (New Zealand, albino, females) on a cholesterol (1%) diet and injected with nicotine (2.78 mg/kg 5 days a week for 6 weeks) demonstrated wider areas of involvement of the internal surface (9.4% vs. 5.7%) in the aorta than rabbits on a cholesterol diet alone. In both stock-fed and cholesterol-fed animals, nicotine produced an increase in aortic triglycerides and a decrease in the free cholesterol content. An increase in phospholipids, particularly in lecithin and cephalin, was observed in the cholesterol-fed rabbits treated with nicotine. Aortic acid mucopolysaccharide composition did not exhibit any significant changes following nicotine treatment. In experiments in vitro, it was shown that heparin and nicotine form a relatively stable complex, in a molar ratio of about 1:20; nicotine also inhibits the hydrolysis of 14C-labeled triolein in a homogenate from rabbit aortic tissue. It is suggested that some of the biological effects of nicotine may be the result of a complex formation between nicotine and heparin in vivo." @default.
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- W2013301971 title "The effect of nicotine on dietary atherogenesis in rabbits" @default.
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- W2013301971 doi "https://doi.org/10.1016/0014-4800(69)90071-9" @default.
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