Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013303527> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2013303527 abstract "Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental disorder characterized by decreased reciprocal social interaction, abnormal communication, and repetitive behaviors with restricted interest. As diagnosis is based on clinical criteria, any potentially relevant rodent models of this heterogeneous disorder should ideally recapitulate these diverse behavioral traits. The BTBR T+ Itpr3tf/J (BTBR) mouse is an established animal model of ASD, displaying repetitive behaviors such as increased grooming, as well as cognitive inflexibility. With respect to social interaction and interest, the juvenile play test has been employed in multiple rodent models of ASD. Here, we show that when BTBR mice are tested in a juvenile social interaction enclosure containing sawdust bedding, they display a repetitive synchronous digging motion. This repetitive motor behavior, referred to as inchworming, was named because of the stereotypic nature of the movements exhibited by the mice while moving horizontally across the floor. Inchworming mice must use their fore- and hind-limbs in synchrony to displace the bedding, performing a minimum of one inward and one outward motion. Although both BTBR and C56BL/6J (B6) mice exhibit this behavior, BTBR mice demonstrate a significantly higher duration and frequency of inchworming and a decreased latency to initiate inchworming when placed in a bedded enclosure. We conclude that this newly described behavior provides a measure of a repetitive motor stereotypy that can be easily measured in animal models of ASD." @default.
- W2013303527 created "2016-06-24" @default.
- W2013303527 creator A5010085174 @default.
- W2013303527 creator A5018391871 @default.
- W2013303527 creator A5059300979 @default.
- W2013303527 creator A5063111142 @default.
- W2013303527 date "2014-07-05" @default.
- W2013303527 modified "2023-10-16" @default.
- W2013303527 title "Inchworming: A Novel Motor Stereotypy in the BTBR <em>T<sup>+</sup> Itpr3<sup>tf</sup></em>/J Mouse Model of Autism" @default.
- W2013303527 cites W1970629813 @default.
- W2013303527 cites W1978783429 @default.
- W2013303527 cites W2000385214 @default.
- W2013303527 cites W2012266823 @default.
- W2013303527 cites W2013335249 @default.
- W2013303527 cites W2036684788 @default.
- W2013303527 cites W2043402111 @default.
- W2013303527 cites W2071797996 @default.
- W2013303527 cites W2072319418 @default.
- W2013303527 cites W2079614275 @default.
- W2013303527 cites W2093802594 @default.
- W2013303527 cites W2098277878 @default.
- W2013303527 cites W2501407678 @default.
- W2013303527 doi "https://doi.org/10.3791/50791" @default.
- W2013303527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4212568" @default.
- W2013303527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25046063" @default.
- W2013303527 hasPublicationYear "2014" @default.
- W2013303527 type Work @default.
- W2013303527 sameAs 2013303527 @default.
- W2013303527 citedByCount "7" @default.
- W2013303527 countsByYear W20133035272016 @default.
- W2013303527 countsByYear W20133035272017 @default.
- W2013303527 countsByYear W20133035272021 @default.
- W2013303527 countsByYear W20133035272022 @default.
- W2013303527 crossrefType "journal-article" @default.
- W2013303527 hasAuthorship W2013303527A5010085174 @default.
- W2013303527 hasAuthorship W2013303527A5018391871 @default.
- W2013303527 hasAuthorship W2013303527A5059300979 @default.
- W2013303527 hasAuthorship W2013303527A5063111142 @default.
- W2013303527 hasBestOaLocation W20133035272 @default.
- W2013303527 hasConcept C112592302 @default.
- W2013303527 hasConcept C134018914 @default.
- W2013303527 hasConcept C138496976 @default.
- W2013303527 hasConcept C15744967 @default.
- W2013303527 hasConcept C169760540 @default.
- W2013303527 hasConcept C17077164 @default.
- W2013303527 hasConcept C205778803 @default.
- W2013303527 hasConcept C2777193897 @default.
- W2013303527 hasConcept C2778117688 @default.
- W2013303527 hasConcept C2778538070 @default.
- W2013303527 hasConcept C2779459141 @default.
- W2013303527 hasConcept C513476851 @default.
- W2013303527 hasConcept C86803240 @default.
- W2013303527 hasConceptScore W2013303527C112592302 @default.
- W2013303527 hasConceptScore W2013303527C134018914 @default.
- W2013303527 hasConceptScore W2013303527C138496976 @default.
- W2013303527 hasConceptScore W2013303527C15744967 @default.
- W2013303527 hasConceptScore W2013303527C169760540 @default.
- W2013303527 hasConceptScore W2013303527C17077164 @default.
- W2013303527 hasConceptScore W2013303527C205778803 @default.
- W2013303527 hasConceptScore W2013303527C2777193897 @default.
- W2013303527 hasConceptScore W2013303527C2778117688 @default.
- W2013303527 hasConceptScore W2013303527C2778538070 @default.
- W2013303527 hasConceptScore W2013303527C2779459141 @default.
- W2013303527 hasConceptScore W2013303527C513476851 @default.
- W2013303527 hasConceptScore W2013303527C86803240 @default.
- W2013303527 hasIssue "89" @default.
- W2013303527 hasLocation W20133035271 @default.
- W2013303527 hasLocation W20133035272 @default.
- W2013303527 hasLocation W20133035273 @default.
- W2013303527 hasLocation W20133035274 @default.
- W2013303527 hasOpenAccess W2013303527 @default.
- W2013303527 hasPrimaryLocation W20133035271 @default.
- W2013303527 hasRelatedWork W1968491860 @default.
- W2013303527 hasRelatedWork W1971662744 @default.
- W2013303527 hasRelatedWork W2000044977 @default.
- W2013303527 hasRelatedWork W2055118542 @default.
- W2013303527 hasRelatedWork W2089478019 @default.
- W2013303527 hasRelatedWork W2125504434 @default.
- W2013303527 hasRelatedWork W2376882036 @default.
- W2013303527 hasRelatedWork W2416986930 @default.
- W2013303527 hasRelatedWork W4280602684 @default.
- W2013303527 hasRelatedWork W4310092953 @default.
- W2013303527 isParatext "false" @default.
- W2013303527 isRetracted "false" @default.
- W2013303527 magId "2013303527" @default.
- W2013303527 workType "article" @default.