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• W2013303734 abstract "Antidepressants, which increase monoamine levels, induce glial cell line-derived neurotrophic factor (GDNF) release in C6 cells. Thus, we examined whether monoamines affect on GDNF release in C6 cells. We found that serotonin (5-HT) specifically increased GDNF mRNA expression and GDNF release in a dose- and time-dependent manner. The 5-HT-induced GDNF release was mediated through the MEK/mitogen-activated protein kinase (MAPK) pathway and, at least, 5-HT2A receptors. The action of 5-HT on GDNF release may provide important insights into the mechanism of antidepressants." @default.
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• W2013303734 date "2004-03-01" @default.
• W2013303734 modified "2023-10-16" @default.
• W2013303734 title "Serotonin increases glial cell line-derived neurotrophic factor release in rat C6 glioblastoma cells" @default.
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• W2013303734 doi "https://doi.org/10.1016/j.brainres.2004.01.009" @default.
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