Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013303904> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2013303904 endingPage "128" @default.
- W2013303904 startingPage "117" @default.
- W2013303904 abstract "The direct vasomotor effects of a number of agents used in the therapy of cerebral circulatory and metabolic disease were studied in isolated segments of cat pial vessels in vitro. Studies were repeated eight times generally, thus permitting the calculation of the mean maximum response—termed E Am (in dynes)—and of the molar agonist concentration required to effect the half-maximal response, termed EC 50 . The results obtained with various agonists were compared to a well-documented vasodilator, acetylcholine ( E Am = −780 dyn; EC 50 = 0,029 μm) and a known vasoconstrictor, 5-hydroxytryptamine ( E Am = + 1630 dyn; EC 50 = 0.036 μm). Papaverine and its derivatives effected a relaxation of the pial arteries with the following order of potency: YC-93 > papaverine > naftidrofuryl > viquidil. The EC 50 for papaverine was 1,5 μm. Methyl xanthine derivatives (aminophylline, pentoxifylline, and theophylline) were essentially inactive, In contrast, drugs that are known to be capable of decreasing the volume of an experimental infarction, many of which are described as α-adrenolytic agents, contracted the isolated cerebrovascular smooth muscle, Their order of efficacy, based on the mean E Am values, was ifenprodil > vincamine > nicergoline > dihydroergotoxine > raubasine, In addition, it was considered worthwhile to determine whether the ifenprodil-induced vasoconstriction occurred when human, rather than cat, pial vessels were studied, Ifenprodil and vincamine contracted the human vessels in a biphasic manner; the EC 50 was calculated to be 2,0 and 30 μm. Based on the above observations, the following comments would appear justified, Firstly, an increase in cerebral blood flow does not necessarily mean a compound is a direct vasodilator. Secondly, the vasoconstrictory actions of some agents correlate well with their anti-ischaemic properties (e.g., ifenprodil, vincamine, and nicergoline), Lastly, one action of effective anti-ischaemic agents might be to reduce flow, by vasoconstriction, in hyperaemic tissue: the inverse “steal” effect." @default.
- W2013303904 created "2016-06-24" @default.
- W2013303904 creator A5004058020 @default.
- W2013303904 creator A5014255777 @default.
- W2013303904 creator A5057442650 @default.
- W2013303904 creator A5073767307 @default.
- W2013303904 creator A5084413123 @default.
- W2013303904 date "1981-03-01" @default.
- W2013303904 modified "2023-10-16" @default.
- W2013303904 title "Direct Vascular Effects of Agents Used in the Pharmacotherapy of Cerebrovascular Disease on Isolated Cerebral Vessels" @default.
- W2013303904 cites W1040432993 @default.
- W2013303904 cites W1982373748 @default.
- W2013303904 cites W1997852999 @default.
- W2013303904 cites W2000102295 @default.
- W2013303904 cites W2053360718 @default.
- W2013303904 cites W2055214794 @default.
- W2013303904 cites W2153821452 @default.
- W2013303904 cites W2325989594 @default.
- W2013303904 cites W2420239091 @default.
- W2013303904 cites W2443412821 @default.
- W2013303904 doi "https://doi.org/10.1038/jcbfm.1981.12" @default.
- W2013303904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7328134" @default.
- W2013303904 hasPublicationYear "1981" @default.
- W2013303904 type Work @default.
- W2013303904 sameAs 2013303904 @default.
- W2013303904 citedByCount "24" @default.
- W2013303904 countsByYear W20133039042012 @default.
- W2013303904 countsByYear W20133039042015 @default.
- W2013303904 countsByYear W20133039042016 @default.
- W2013303904 countsByYear W20133039042017 @default.
- W2013303904 countsByYear W20133039042023 @default.
- W2013303904 crossrefType "journal-article" @default.
- W2013303904 hasAuthorship W2013303904A5004058020 @default.
- W2013303904 hasAuthorship W2013303904A5014255777 @default.
- W2013303904 hasAuthorship W2013303904A5057442650 @default.
- W2013303904 hasAuthorship W2013303904A5073767307 @default.
- W2013303904 hasAuthorship W2013303904A5084413123 @default.
- W2013303904 hasConcept C120770815 @default.
- W2013303904 hasConcept C126322002 @default.
- W2013303904 hasConcept C170493617 @default.
- W2013303904 hasConcept C171614378 @default.
- W2013303904 hasConcept C185592680 @default.
- W2013303904 hasConcept C2775864247 @default.
- W2013303904 hasConcept C2776214587 @default.
- W2013303904 hasConcept C2776952824 @default.
- W2013303904 hasConcept C2777952589 @default.
- W2013303904 hasConcept C2778938600 @default.
- W2013303904 hasConcept C2779961880 @default.
- W2013303904 hasConcept C2780376555 @default.
- W2013303904 hasConcept C2781005078 @default.
- W2013303904 hasConcept C42219234 @default.
- W2013303904 hasConcept C61174792 @default.
- W2013303904 hasConcept C71924100 @default.
- W2013303904 hasConcept C84393581 @default.
- W2013303904 hasConcept C98274493 @default.
- W2013303904 hasConceptScore W2013303904C120770815 @default.
- W2013303904 hasConceptScore W2013303904C126322002 @default.
- W2013303904 hasConceptScore W2013303904C170493617 @default.
- W2013303904 hasConceptScore W2013303904C171614378 @default.
- W2013303904 hasConceptScore W2013303904C185592680 @default.
- W2013303904 hasConceptScore W2013303904C2775864247 @default.
- W2013303904 hasConceptScore W2013303904C2776214587 @default.
- W2013303904 hasConceptScore W2013303904C2776952824 @default.
- W2013303904 hasConceptScore W2013303904C2777952589 @default.
- W2013303904 hasConceptScore W2013303904C2778938600 @default.
- W2013303904 hasConceptScore W2013303904C2779961880 @default.
- W2013303904 hasConceptScore W2013303904C2780376555 @default.
- W2013303904 hasConceptScore W2013303904C2781005078 @default.
- W2013303904 hasConceptScore W2013303904C42219234 @default.
- W2013303904 hasConceptScore W2013303904C61174792 @default.
- W2013303904 hasConceptScore W2013303904C71924100 @default.
- W2013303904 hasConceptScore W2013303904C84393581 @default.
- W2013303904 hasConceptScore W2013303904C98274493 @default.
- W2013303904 hasIssue "1" @default.
- W2013303904 hasLocation W20133039041 @default.
- W2013303904 hasLocation W20133039042 @default.
- W2013303904 hasOpenAccess W2013303904 @default.
- W2013303904 hasPrimaryLocation W20133039041 @default.
- W2013303904 hasRelatedWork W1898334791 @default.
- W2013303904 hasRelatedWork W1974104292 @default.
- W2013303904 hasRelatedWork W2017204200 @default.
- W2013303904 hasRelatedWork W2034053716 @default.
- W2013303904 hasRelatedWork W2039320407 @default.
- W2013303904 hasRelatedWork W2043473992 @default.
- W2013303904 hasRelatedWork W2049296172 @default.
- W2013303904 hasRelatedWork W2059401172 @default.
- W2013303904 hasRelatedWork W2065441702 @default.
- W2013303904 hasRelatedWork W2107438925 @default.
- W2013303904 hasVolume "1" @default.
- W2013303904 isParatext "false" @default.
- W2013303904 isRetracted "false" @default.
- W2013303904 magId "2013303904" @default.
- W2013303904 workType "article" @default.