FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013304849> ?p ?o ?g. }

• W2013304849 endingPage "1311" @default.
• W2013304849 startingPage "1294" @default.
• W2013304849 abstract "Ras proteins regulate a wide range of biological processes by interacting with a variety of effector proteins. In addition to the known role in tumorigensis, the activated form of Ras exhibits growth-inhibitory effects by unknown mechanisms. Several Ras effector proteins identified as mediators of apoptosis and cell-cycle arrest also exhibit properties normally associated with tumor suppressor proteins. Here, we show that Ras effector RASSF5/NORE-1 binds strongly to K-Ras but weakly to both N-Ras and H-Ras. RASSF5 was found to localize both in the nucleus and the nucleolus in contrast to other Ras effector proteins, RASSF1C and RASSF2, which are localized in the nucleus and excluded from nucleolus. A 50 amino acid residue transferable arginine-rich nucleolar localization signal (NoLS) identified in RASSF5 is capable of interacting with importin-beta and transporting the cargo into the nucleolus. Surprisingly, similar arginine-rich signals identified in RASSF1C and RASSF2 interact with importin-alpha and transport the heterologous cytoplasmic proteins to the nucleus. Interestingly, mutation of arginine residues within these nuclear targeting signals prevented interaction of Ras effector proteins with respective transport receptors and abolished their nuclear translocation. These results provide evidence for the first time that arginine-rich signals are able to recognize different nuclear import receptors and transport the RASSF proteins into distinct sub-cellular compartments. In addition, our data suggest that the nuclear localization of RASSF5 is critical for its cell growth control activity. Together, these data suggest that the transport of Ras effector superfamily proteins into the nucleus/nucleolus may play a vital role in modulating Ras-mediated cell proliferation during tumorigenesis." @default.
• W2013304849 created "2016-06-24" @default.
• W2013304849 creator A5010231222 @default.
• W2013304849 creator A5037834317 @default.
• W2013304849 creator A5045283657 @default.
• W2013304849 creator A5066700979 @default.
• W2013304849 date "2007-04-01" @default.
• W2013304849 modified "2023-09-25" @default.
• W2013304849 title "Nuclear Transport of Ras-associated Tumor Suppressor Proteins: Different Transport Receptor Binding Specificities for Arginine-rich Nuclear Targeting Signals" @default.
• W2013304849 cites W103445271 @default.
• W2013304849 cites W1485459479 @default.
• W2013304849 cites W1537797514 @default.
• W2013304849 cites W1560780012 @default.
• W2013304849 cites W1560988201 @default.
• W2013304849 cites W1916927082 @default.
• W2013304849 cites W1968910405 @default.
• W2013304849 cites W1970666030 @default.
• W2013304849 cites W1973052124 @default.
• W2013304849 cites W1973944553 @default.
• W2013304849 cites W1985081377 @default.
• W2013304849 cites W1989823885 @default.
• W2013304849 cites W1990578478 @default.
• W2013304849 cites W1999441881 @default.
• W2013304849 cites W2006372060 @default.
• W2013304849 cites W2014673108 @default.
• W2013304849 cites W2017284082 @default.
• W2013304849 cites W2034059681 @default.
• W2013304849 cites W2037448519 @default.
• W2013304849 cites W2040257851 @default.
• W2013304849 cites W2052333525 @default.
• W2013304849 cites W2064478922 @default.
• W2013304849 cites W2066074044 @default.
• W2013304849 cites W2070210483 @default.
• W2013304849 cites W2073681698 @default.
• W2013304849 cites W2074332692 @default.
• W2013304849 cites W2076826746 @default.
• W2013304849 cites W2080719056 @default.
• W2013304849 cites W2083522244 @default.
• W2013304849 cites W2083563185 @default.
• W2013304849 cites W2085140159 @default.
• W2013304849 cites W2086725260 @default.
• W2013304849 cites W2088985926 @default.
• W2013304849 cites W2092641158 @default.
• W2013304849 cites W2100861348 @default.
• W2013304849 cites W2105193974 @default.
• W2013304849 cites W2125824349 @default.
• W2013304849 cites W2135242575 @default.
• W2013304849 cites W2138834926 @default.
• W2013304849 cites W2141354259 @default.
• W2013304849 cites W2144031018 @default.
• W2013304849 cites W2148176502 @default.
• W2013304849 cites W2154883764 @default.
• W2013304849 cites W2158150128 @default.
• W2013304849 cites W2158677075 @default.
• W2013304849 cites W2160232849 @default.
• W2013304849 cites W2165108293 @default.
• W2013304849 cites W2165639753 @default.
• W2013304849 cites W2173344695 @default.
• W2013304849 cites W4211020343 @default.
• W2013304849 cites W4235430490 @default.
• W2013304849 cites W4245546812 @default.
• W2013304849 doi "https://doi.org/10.1016/j.jmb.2007.01.026" @default.
• W2013304849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17320110" @default.
• W2013304849 hasPublicationYear "2007" @default.
• W2013304849 type Work @default.
• W2013304849 sameAs 2013304849 @default.
• W2013304849 citedByCount "31" @default.
• W2013304849 countsByYear W20133048492012 @default.
• W2013304849 countsByYear W20133048492013 @default.
• W2013304849 countsByYear W20133048492014 @default.
• W2013304849 countsByYear W20133048492016 @default.
• W2013304849 countsByYear W20133048492017 @default.
• W2013304849 countsByYear W20133048492018 @default.
• W2013304849 countsByYear W20133048492022 @default.
• W2013304849 countsByYear W20133048492023 @default.
• W2013304849 crossrefType "journal-article" @default.
• W2013304849 hasAuthorship W2013304849A5010231222 @default.
• W2013304849 hasAuthorship W2013304849A5037834317 @default.
• W2013304849 hasAuthorship W2013304849A5045283657 @default.
• W2013304849 hasAuthorship W2013304849A5066700979 @default.
• W2013304849 hasConcept C104317684 @default.
• W2013304849 hasConcept C133882971 @default.
• W2013304849 hasConcept C183873130 @default.
• W2013304849 hasConcept C190062978 @default.
• W2013304849 hasConcept C2777336224 @default.
• W2013304849 hasConcept C2780114586 @default.
• W2013304849 hasConcept C29512474 @default.
• W2013304849 hasConcept C49805395 @default.
• W2013304849 hasConcept C51785407 @default.
• W2013304849 hasConcept C55493867 @default.
• W2013304849 hasConcept C57581600 @default.
• W2013304849 hasConcept C59157529 @default.
• W2013304849 hasConcept C86339819 @default.
• W2013304849 hasConcept C86803240 @default.
• W2013304849 hasConcept C95444343 @default.
• W2013304849 hasConceptScore W2013304849C104317684 @default.
• W2013304849 hasConceptScore W2013304849C133882971 @default.
• W2013304849 hasConceptScore W2013304849C183873130 @default.

• next