FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013307510> ?p ?o ?g. }

• W2013307510 abstract "Emergence of HIV-1 drug resistance may limit the sustained benefits of antiretroviral therapy (ART) in settings with limited laboratory monitoring and drug options.Surveillance of drug resistance and subtypes in HIV-1 patients failing ART in Cuba.This study compiled data of ART-experienced HIV-1 patients attending a clinical center in Havana in 2003 and 2009-2011. The first period included results of a cross-sectional study, whereas in the second period genotyping was performed as part of routine care. Drug resistance mutations and levels were determined using HIVdb version 6.0.9.Seventy-six percent received solely ART containing at least 3 drugs, of which 79.1% ever receiving unboosted protease inhibitors (PI). Patients from 2009 to 2011 were longer treated and exposed to more ART regimens. Subtype B (39%) and CRF19_cpx (18%) were the most prevalent genetic forms. Subtype distribution did not change significantly between both periods, except for BG recombinants that increased from 6% to 14%. Nucleoside reverse transcriptase inhibitor (NRTI), non-nucleoside RTI (NNRTI) and PI mutations were present in 69.5%, 54.8% and 44.4%. Full-class resistance (FCR) to NRTI, NNRTI, PI and multidrug resistance (MDR) were detected in 31.8%, 37.9%, 18.5% and 15.4%. FCR to NRTI, NNRTI, PI and MDR were present in 9.8%, 14.1%, 0%, 0% after first-line failure and in 19.8%, 20.8%, 2.9% and 2.9% after second-line failure.Our study found a high prevalence of drug resistance and supports the need for appropriate laboratory monitoring in clinical practice and access to drug options in case of virological failure." @default.
• W2013307510 created "2016-06-24" @default.
• W2013307510 creator A5004636866 @default.
• W2013307510 creator A5009891813 @default.
• W2013307510 creator A5010738650 @default.
• W2013307510 creator A5012960380 @default.
• W2013307510 creator A5014615935 @default.
• W2013307510 creator A5017745729 @default.
• W2013307510 creator A5019343181 @default.
• W2013307510 creator A5028751798 @default.
• W2013307510 creator A5029820433 @default.
• W2013307510 creator A5032450279 @default.
• W2013307510 creator A5043949126 @default.
• W2013307510 creator A5052181814 @default.
• W2013307510 creator A5054852363 @default.
• W2013307510 creator A5055988737 @default.
• W2013307510 creator A5058415272 @default.
• W2013307510 creator A5059782764 @default.
• W2013307510 creator A5062747050 @default.
• W2013307510 creator A5065034994 @default.
• W2013307510 creator A5069677846 @default.
• W2013307510 date "2012-12-01" @default.
• W2013307510 modified "2023-10-18" @default.
• W2013307510 title "High frequency of antiviral drug resistance and non-B subtypes in HIV-1 patients failing antiviral therapy in Cuba" @default.
• W2013307510 cites W1512806825 @default.
• W2013307510 cites W1971947147 @default.
• W2013307510 cites W1972934377 @default.
• W2013307510 cites W1986731166 @default.
• W2013307510 cites W1995303191 @default.
• W2013307510 cites W2041510111 @default.
• W2013307510 cites W2045871034 @default.
• W2013307510 cites W2053678610 @default.
• W2013307510 cites W2062145237 @default.
• W2013307510 cites W2065135419 @default.
• W2013307510 cites W2075189679 @default.
• W2013307510 cites W2075921620 @default.
• W2013307510 cites W2085548662 @default.
• W2013307510 cites W2089151192 @default.
• W2013307510 cites W2100151011 @default.
• W2013307510 cites W2117681036 @default.
• W2013307510 cites W2132632499 @default.
• W2013307510 cites W2133166320 @default.
• W2013307510 cites W2139570378 @default.
• W2013307510 cites W2140227711 @default.
• W2013307510 cites W2151964493 @default.
• W2013307510 cites W2163400707 @default.
• W2013307510 cites W2168731191 @default.
• W2013307510 cites W2183940924 @default.
• W2013307510 doi "https://doi.org/10.1016/j.jcv.2012.08.019" @default.
• W2013307510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22981617" @default.
• W2013307510 hasPublicationYear "2012" @default.
• W2013307510 type Work @default.
• W2013307510 sameAs 2013307510 @default.
• W2013307510 citedByCount "13" @default.
• W2013307510 countsByYear W20133075102013 @default.
• W2013307510 countsByYear W20133075102014 @default.
• W2013307510 countsByYear W20133075102015 @default.
• W2013307510 countsByYear W20133075102018 @default.
• W2013307510 countsByYear W20133075102020 @default.
• W2013307510 crossrefType "journal-article" @default.
• W2013307510 hasAuthorship W2013307510A5004636866 @default.
• W2013307510 hasAuthorship W2013307510A5009891813 @default.
• W2013307510 hasAuthorship W2013307510A5010738650 @default.
• W2013307510 hasAuthorship W2013307510A5012960380 @default.
• W2013307510 hasAuthorship W2013307510A5014615935 @default.
• W2013307510 hasAuthorship W2013307510A5017745729 @default.
• W2013307510 hasAuthorship W2013307510A5019343181 @default.
• W2013307510 hasAuthorship W2013307510A5028751798 @default.
• W2013307510 hasAuthorship W2013307510A5029820433 @default.
• W2013307510 hasAuthorship W2013307510A5032450279 @default.
• W2013307510 hasAuthorship W2013307510A5043949126 @default.
• W2013307510 hasAuthorship W2013307510A5052181814 @default.
• W2013307510 hasAuthorship W2013307510A5054852363 @default.
• W2013307510 hasAuthorship W2013307510A5055988737 @default.
• W2013307510 hasAuthorship W2013307510A5058415272 @default.
• W2013307510 hasAuthorship W2013307510A5059782764 @default.
• W2013307510 hasAuthorship W2013307510A5062747050 @default.
• W2013307510 hasAuthorship W2013307510A5065034994 @default.
• W2013307510 hasAuthorship W2013307510A5069677846 @default.
• W2013307510 hasConcept C104317684 @default.
• W2013307510 hasConcept C114851261 @default.
• W2013307510 hasConcept C126322002 @default.
• W2013307510 hasConcept C135763542 @default.
• W2013307510 hasConcept C142462285 @default.
• W2013307510 hasConcept C156719811 @default.
• W2013307510 hasConcept C159047783 @default.
• W2013307510 hasConcept C182707283 @default.
• W2013307510 hasConcept C2776694085 @default.
• W2013307510 hasConcept C2777351918 @default.
• W2013307510 hasConcept C2778451633 @default.
• W2013307510 hasConcept C2780775027 @default.
• W2013307510 hasConcept C2781143361 @default.
• W2013307510 hasConcept C2993143319 @default.
• W2013307510 hasConcept C3013748606 @default.
• W2013307510 hasConcept C31467283 @default.
• W2013307510 hasConcept C49105822 @default.
• W2013307510 hasConcept C500440147 @default.
• W2013307510 hasConcept C55493867 @default.
• W2013307510 hasConcept C71924100 @default.
• W2013307510 hasConcept C86803240 @default.

• next