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- W2013313332 abstract "Kinetin (Kn) is a synthetic cytokinin plant growth hormone having some senescence-retarding effects in plants. Its effects on animal cells have been, until now, best considered as growth inhibitory and anti-tumorigenic. However, we have observed that an addition of 40-200 μM Kn in the culture medium of human diploid fibroblasts can both delay the onset and decrease the extent of many of the ageing characteristics that appear during serial passaging of normal cells in culture. Age-related changes that are affected by Kn include morphological alterations, growth rates, cell size, cytoskeletal organisation, macromolecular synthesis and the intensity of autofluorescence due to the oxidative damage product lipofuscin. These anti-ageing effects of Kn are achieved without any increase in the cell culture lifespan in terms of maximum proliferative capacity in vitro." @default.
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- W2013313332 date "1994-06-01" @default.
- W2013313332 modified "2023-10-18" @default.
- W2013313332 title "Kinetin Delays the Onset of Aging Characteristics in Human Fibroblasts" @default.
- W2013313332 doi "https://doi.org/10.1006/bbrc.1994.1752" @default.
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