Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013313672> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2013313672 endingPage "???" @default.
- W2013313672 startingPage "070807042352001" @default.
- W2013313672 abstract "Machado-Joseph disease (MJD SCA3), a spinocerebellar ataxia related to expansion of a CAG tract, has already been related to anticipation and meiotic drift. However, fitness of MJD carriers has been little studied.To analyze genetic fitness of MJD patients, comparing them to their unaffected relatives and to the general population (GP) of origin.182 informants, belonging to 82 MJD families, agreed to participate in the study. Informants supplied data about 828 MJD patients. Number of children (NC), gender, age, school attainment, menarche and menopause were compared between general and emeritus (older than 45 years of age or deceased) groups.Mean NC of the GP and of MJD patients were respectively 1.90 and 2.93+/-2.3 (p = 0.0037). Comparisons within families also showed differences: the mean NC of unaffected and affected emeritus MJD women were, respectively, 2.68 and 3.89 (p = 0.0037). Affected MJD women had earlier mean ages at the delivery of their first child and menopause (p < 0.011 and 0.07, respectively). Among affected women those who did not have children had larger CAG tracts than those who had children (p < 0.05).MJD enhances the fitness of its carriers, and this phenomenon seems to have a biological basis." @default.
- W2013313672 created "2016-06-24" @default.
- W2013313672 creator A5000873384 @default.
- W2013313672 creator A5004413817 @default.
- W2013313672 creator A5005292318 @default.
- W2013313672 creator A5017294567 @default.
- W2013313672 creator A5031106644 @default.
- W2013313672 date "2007-08-07" @default.
- W2013313672 modified "2023-10-01" @default.
- W2013313672 title "Machado-Joseph Disease Enhances Genetic Fitness: A Comparison Between Affected and Unaffected Women and Between MJD and the General Population" @default.
- W2013313672 cites W1984093673 @default.
- W2013313672 cites W1991925160 @default.
- W2013313672 cites W2060616889 @default.
- W2013313672 cites W2064499510 @default.
- W2013313672 cites W2073012734 @default.
- W2013313672 cites W2105954114 @default.
- W2013313672 cites W2115929817 @default.
- W2013313672 cites W2118415943 @default.
- W2013313672 cites W2127135035 @default.
- W2013313672 cites W2137546687 @default.
- W2013313672 cites W2137697428 @default.
- W2013313672 cites W2158279080 @default.
- W2013313672 cites W2992097690 @default.
- W2013313672 cites W4299787297 @default.
- W2013313672 doi "https://doi.org/10.1111/j.1469-1809.2007.00388.x" @default.
- W2013313672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17683516" @default.
- W2013313672 hasPublicationYear "2007" @default.
- W2013313672 type Work @default.
- W2013313672 sameAs 2013313672 @default.
- W2013313672 citedByCount "15" @default.
- W2013313672 countsByYear W20133136722012 @default.
- W2013313672 countsByYear W20133136722013 @default.
- W2013313672 countsByYear W20133136722015 @default.
- W2013313672 countsByYear W20133136722016 @default.
- W2013313672 countsByYear W20133136722019 @default.
- W2013313672 countsByYear W20133136722020 @default.
- W2013313672 countsByYear W20133136722021 @default.
- W2013313672 countsByYear W20133136722023 @default.
- W2013313672 crossrefType "journal-article" @default.
- W2013313672 hasAuthorship W2013313672A5000873384 @default.
- W2013313672 hasAuthorship W2013313672A5004413817 @default.
- W2013313672 hasAuthorship W2013313672A5005292318 @default.
- W2013313672 hasAuthorship W2013313672A5017294567 @default.
- W2013313672 hasAuthorship W2013313672A5031106644 @default.
- W2013313672 hasBestOaLocation W20133136722 @default.
- W2013313672 hasConcept C126322002 @default.
- W2013313672 hasConcept C144024400 @default.
- W2013313672 hasConcept C149923435 @default.
- W2013313672 hasConcept C154945302 @default.
- W2013313672 hasConcept C15744967 @default.
- W2013313672 hasConcept C176777502 @default.
- W2013313672 hasConcept C2777748165 @default.
- W2013313672 hasConcept C2779134260 @default.
- W2013313672 hasConcept C2779500118 @default.
- W2013313672 hasConcept C2908647359 @default.
- W2013313672 hasConcept C29456083 @default.
- W2013313672 hasConcept C41008148 @default.
- W2013313672 hasConcept C4258228 @default.
- W2013313672 hasConcept C71924100 @default.
- W2013313672 hasConcept C74909509 @default.
- W2013313672 hasConceptScore W2013313672C126322002 @default.
- W2013313672 hasConceptScore W2013313672C144024400 @default.
- W2013313672 hasConceptScore W2013313672C149923435 @default.
- W2013313672 hasConceptScore W2013313672C154945302 @default.
- W2013313672 hasConceptScore W2013313672C15744967 @default.
- W2013313672 hasConceptScore W2013313672C176777502 @default.
- W2013313672 hasConceptScore W2013313672C2777748165 @default.
- W2013313672 hasConceptScore W2013313672C2779134260 @default.
- W2013313672 hasConceptScore W2013313672C2779500118 @default.
- W2013313672 hasConceptScore W2013313672C2908647359 @default.
- W2013313672 hasConceptScore W2013313672C29456083 @default.
- W2013313672 hasConceptScore W2013313672C41008148 @default.
- W2013313672 hasConceptScore W2013313672C4258228 @default.
- W2013313672 hasConceptScore W2013313672C71924100 @default.
- W2013313672 hasConceptScore W2013313672C74909509 @default.
- W2013313672 hasIssue "0" @default.
- W2013313672 hasLocation W20133136721 @default.
- W2013313672 hasLocation W20133136722 @default.
- W2013313672 hasLocation W20133136723 @default.
- W2013313672 hasOpenAccess W2013313672 @default.
- W2013313672 hasPrimaryLocation W20133136721 @default.
- W2013313672 hasRelatedWork W1513481287 @default.
- W2013313672 hasRelatedWork W1977339741 @default.
- W2013313672 hasRelatedWork W1998361697 @default.
- W2013313672 hasRelatedWork W2035449435 @default.
- W2013313672 hasRelatedWork W2046604541 @default.
- W2013313672 hasRelatedWork W2071065526 @default.
- W2013313672 hasRelatedWork W2079054865 @default.
- W2013313672 hasRelatedWork W2280080604 @default.
- W2013313672 hasRelatedWork W3100598802 @default.
- W2013313672 hasRelatedWork W4248988872 @default.
- W2013313672 hasVolume "0" @default.
- W2013313672 isParatext "false" @default.
- W2013313672 isRetracted "false" @default.
- W2013313672 magId "2013313672" @default.
- W2013313672 workType "article" @default.